STRINGSTRING
SMAD4 SMAD4 ENSPANP00000047688 ENSPANP00000047688 KRAS KRAS LOC101021327 LOC101021327 TGFBR1 TGFBR1 LOC100997503 LOC100997503 AKT2 AKT2 ENSPANP00000045653 ENSPANP00000045653 LOC100997529 LOC100997529 RAF1 RAF1 AREG AREG ENSPANP00000041348 ENSPANP00000041348 RHOA RHOA BAK1 BAK1 MAP2K2 MAP2K2 APC APC MAPK10 MAPK10 SMAD2 SMAD2 TGFA TGFA BAX BAX APPL1 APPL1 LEF1 LEF1 PIK3CB PIK3CB MAPK8 MAPK8 TP53 TP53 LOC100998766 LOC100998766 PMAIP1 PMAIP1 ENSPANP00000029069 ENSPANP00000029069 RALGDS RALGDS TCF7L2 TCF7L2 RPS6KB1 RPS6KB1 GSK3B GSK3B MAPK1 MAPK1 DCC DCC LOC101008579 LOC101008579 ENSPANP00000024626 ENSPANP00000024626 ENSPANP00000024582 ENSPANP00000024582 RAC3 RAC3 GADD45B GADD45B ENSPANP00000022457 ENSPANP00000022457 MAP2K1 MAP2K1 TCF7 TCF7 ENSPANP00000021298 ENSPANP00000021298 RGL4 RGL4 GADD45G GADD45G BRAF BRAF ERAS ERAS BCL2L11 BCL2L11 ENSPANP00000017591 ENSPANP00000017591 SOS1 SOS1 LOC100997719 LOC100997719 ENSPANP00000017007 ENSPANP00000017007 SOS2 SOS2 EREG EREG RALB RALB AXIN2 AXIN2 BIRC5 BIRC5 GRB2 GRB2 TGFB3 TGFB3 FOS FOS MTOR MTOR RALA RALA PIK3CD PIK3CD SMAD3 SMAD3 AXIN1 AXIN1 AKT1 AKT1 RAC2 RAC2 CDKN1A CDKN1A MAPK3 MAPK3 APC2 APC2 NRAS NRAS MAPK9 MAPK9 ENSPANP00000009247 ENSPANP00000009247 POLK POLK EGF EGF GADD45A GADD45A LOC103876580 LOC103876580 MYC MYC LOC101025906 LOC101025906 RPS6KB2 RPS6KB2 MSH6 MSH6 ENSPANP00000007612 ENSPANP00000007612 LOC100997587 LOC100997587 PIK3R2 PIK3R2 DDB2 DDB2 MSH3 MSH3 RAC1 RAC1 TGFBR2 TGFBR2 EPGN EPGN CASP3 CASP3 MSH2 MSH2 CTNNB1 CTNNB1 PIK3CA PIK3CA TGFB2 TGFB2 TGFB1 TGFB1 EGFR EGFR ARAF ARAF BBC3 BBC3 MLH1 MLH1 TCF7L1 TCF7L1 CASP9 CASP9 C7orf31 C7orf31 AKT3 AKT3 PIK3R3 PIK3R3 PPP1R14B PPP1R14B ENSPANP00000001773 ENSPANP00000001773 BCL2 BCL2 PIK3R1 PIK3R1 HRAS HRAS RHOC RHOC BAD BAD CCND1 CCND1 CSDE1 CSDE1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ENSPANP00000047688Uncharacterized protein. (212 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
LOC101021327Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
LOC100997503Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSPANP00000045653CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (195 aa)
LOC100997529Cytochrome c. (105 aa)
RAF1Uncharacterized protein. (668 aa)
AREGAmphiregulin. (274 aa)
ENSPANP00000041348Uncharacterized protein. (182 aa)
RHOARas homolog family member A. (193 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (385 aa)
APCAPC regulator of WNT signaling pathway. (2871 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
SMAD2Mothers against decapentaplegic homolog. (472 aa)
TGFATransforming growth factor alpha. (166 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (715 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
LOC100998766Ras-GEF domain-containing protein. (591 aa)
PMAIP1Uncharacterized protein. (133 aa)
ENSPANP00000029069Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (95 aa)
RALGDSUncharacterized protein. (915 aa)
TCF7L2Transcription factor 7 like 2. (529 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
DCCDCC netrin 1 receptor. (1447 aa)
LOC101008579Cytochrome c. (105 aa)
ENSPANP00000024626Uncharacterized protein. (82 aa)
ENSPANP00000024582Uncharacterized protein. (147 aa)
RAC3Rac family small GTPase 3. (192 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (176 aa)
ENSPANP00000022457Uncharacterized protein. (208 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
TCF7Transcription factor 7. (480 aa)
ENSPANP00000021298Ras-GEF domain-containing protein. (553 aa)
RGL4Ral guanine nucleotide dissociation stimulator like 4. (540 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
ERASES cell expressed Ras. (233 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
ENSPANP00000017591Ras-GEF domain-containing protein. (579 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
LOC100997719Ras-GEF domain-containing protein. (593 aa)
ENSPANP00000017007Ras-GEF domain-containing protein. (530 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
EREGEpiregulin. (169 aa)
RALBRAS like proto-oncogene B. (206 aa)
AXIN2Axin 2. (844 aa)
BIRC5Uncharacterized protein. (144 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
RALARAS like proto-oncogene A. (206 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
AXIN1Axin 1, isoform 1 (Predicted). (867 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RAC2Rac family small GTPase 2. (192 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
APC2APC regulator of WNT signaling pathway 2. (2301 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ENSPANP00000009247Uncharacterized protein. (583 aa)
POLKDNA polymerase kappa. (870 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1161 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
LOC103876580Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
LOC101025906Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa)
ENSPANP00000007612Uncharacterized protein. (190 aa)
LOC100997587Ras-GEF domain-containing protein. (590 aa)
PIK3R2Uncharacterized protein. (721 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
MSH3MutS homolog 3. (1218 aa)
RAC1Rac family small GTPase 1. (211 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
EPGNEpithelial mitogen. (154 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (905 aa)
CTNNB1Catenin beta 1. (781 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
BBC3BCL2 binding component 3. (261 aa)
MLH1MutL homolog 1. (756 aa)
TCF7L1Transcription factor 7 like 1. (589 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (416 aa)
C7orf31Chromosome 7 open reading frame 31. (590 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PPP1R14BUncharacterized protein. (207 aa)
ENSPANP00000001773Uncharacterized protein. (189 aa)
BCL2BCL2 apoptosis regulator. (238 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
HRASUncharacterized protein. (189 aa)
RHOCRas homolog family member C. (193 aa)
BADBCL2 associated agonist of cell death. (168 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
CSDE1Cold shock domain containing E1. (844 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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