STRINGSTRING
ELK1 ELK1 KRAS KRAS AKT2 AKT2 RAF1 RAF1 BAK1 BAK1 MAP2K2 MAP2K2 APC APC ERBB2 ERBB2 BAX BAX ENSPANP00000035911 ENSPANP00000035911 LEF1 LEF1 PIK3CB PIK3CB TP53 TP53 CTNNA2 CTNNA2 ENSPANP00000029629 ENSPANP00000029629 TCF7L2 TCF7L2 GSK3B GSK3B MAPK1 MAPK1 ENSPANP00000024626 ENSPANP00000024626 ENSPANP00000024582 ENSPANP00000024582 GADD45B GADD45B ENSPANP00000022457 ENSPANP00000022457 MAP2K1 MAP2K1 ENSPANP00000021910 ENSPANP00000021910 TCF7 TCF7 PTEN PTEN CTNNA3 CTNNA3 GADD45G GADD45G BRAF BRAF ERAS ERAS SOS1 SOS1 SOS2 SOS2 AXIN2 AXIN2 GRB2 GRB2 PIK3CD PIK3CD AXIN1 AXIN1 AKT1 AKT1 CDKN1A CDKN1A MAPK3 MAPK3 APC2 APC2 NRAS NRAS ILK ILK ENSPANP00000009247 ENSPANP00000009247 POLK POLK EGF EGF TPTE2 TPTE2 GADD45A GADD45A MYC MYC ENSPANP00000007612 ENSPANP00000007612 PIK3R2 PIK3R2 DDB2 DDB2 CTNNB1 CTNNB1 PIK3CA PIK3CA FOXO3 FOXO3 EGFR EGFR ARAF ARAF PDPK1 PDPK1 MLH1 MLH1 TCF7L1 TCF7L1 CASP9 CASP9 CTNNA1 CTNNA1 AKT3 AKT3 PIK3R3 PIK3R3 PPP1R14B PPP1R14B ENSPANP00000001773 ENSPANP00000001773 PIK3R1 PIK3R1 CDH1 CDH1 HRAS HRAS BAD BAD CCND1 CCND1 CSDE1 CSDE1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ELK1ETS domain-containing protein. (428 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RAF1Uncharacterized protein. (668 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (385 aa)
APCAPC regulator of WNT signaling pathway. (2871 aa)
ERBB2Receptor protein-tyrosine kinase. (1399 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
ENSPANP00000035911Protein kinase domain-containing protein. (137 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
CTNNA2Catenin alpha 2. (953 aa)
ENSPANP00000029629ETS domain-containing protein. (384 aa)
TCF7L2Transcription factor 7 like 2. (529 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ENSPANP00000024626Uncharacterized protein. (82 aa)
ENSPANP00000024582Uncharacterized protein. (147 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (176 aa)
ENSPANP00000022457Uncharacterized protein. (208 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ENSPANP00000021910Uncharacterized protein. (822 aa)
TCF7Transcription factor 7. (480 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
CTNNA3Catenin alpha 3. (895 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
ERASES cell expressed Ras. (233 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
AXIN2Axin 2. (844 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
AXIN1Axin 1, isoform 1 (Predicted). (867 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
APC2APC regulator of WNT signaling pathway 2. (2301 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ILKIntegrin linked kinase. (526 aa)
ENSPANP00000009247Uncharacterized protein. (583 aa)
POLKDNA polymerase kappa. (870 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1161 aa)
TPTE2Uncharacterized protein. (550 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
ENSPANP00000007612Uncharacterized protein. (190 aa)
PIK3R2Uncharacterized protein. (721 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
CTNNB1Catenin beta 1. (781 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FOXO3Forkhead box O3. (672 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (347 aa)
MLH1MutL homolog 1. (756 aa)
TCF7L1Transcription factor 7 like 1. (589 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (416 aa)
CTNNA1Catenin alpha 1. (906 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PPP1R14BUncharacterized protein. (207 aa)
ENSPANP00000001773Uncharacterized protein. (189 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa)
HRASUncharacterized protein. (189 aa)
BADBCL2 associated agonist of cell death. (168 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
CSDE1Cold shock domain containing E1. (844 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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