STRINGSTRING
KRAS KRAS MAPK3 MAPK3 CALM3 CALM3 CDK6 CDK6 NRAS NRAS PLCG2 PLCG2 CAMK1G CAMK1G CAMK4 CAMK4 ENSPANP00000009247 ENSPANP00000009247 POLK POLK EGF EGF TPTE2 TPTE2 GADD45A GADD45A CALML3 CALML3 PDGFRB PDGFRB CDK4 CDK4 PIK3R2 PIK3R2 PDGFRA PDGFRA DDB2 DDB2 CAMK2A CAMK2A PIK3CA PIK3CA EGFR EGFR ARAF ARAF AKT3 AKT3 PIK3R3 PIK3R3 ARSI ARSI ENSPANP00000001773 ENSPANP00000001773 E2F2 E2F2 PIK3R1 PIK3R1 SHC2 SHC2 HRAS HRAS CAMK1 CAMK1 CCND1 CCND1 CSDE1 CSDE1 AKT1 AKT1 PDGFB PDGFB CEP152 CEP152 SHC4 SHC4 CALML4 CALML4 PIK3CD PIK3CD CALM1 CALM1 MTOR MTOR GRB2 GRB2 PRKCA PRKCA E2F1 E2F1 SOS2 SOS2 SOS1 SOS1 PLCG1 PLCG1 ERAS ERAS RB1 RB1 MDM2 MDM2 BRAF BRAF SHC3 SHC3 GADD45G GADD45G CAMK1D CAMK1D PDGFA PDGFA CAMK2G CAMK2G PTEN PTEN PRKCG PRKCG MAP2K1 MAP2K1 CDKN2B CDKN2B ENSPANP00000022457 ENSPANP00000022457 GADD45B GADD45B MAPK1 MAPK1 CALM2 CALM2 ENSPANP00000030371 ENSPANP00000030371 E2F3 E2F3 ENSPANP00000033457 ENSPANP00000033457 TP53 TP53 PIK3CB PIK3CB CALML6 CALML6 SHC1 SHC1 BAX BAX IGF1R IGF1R TGFA TGFA IGF1 IGF1 MAP2K2 MAP2K2 BAK1 BAK1 RAF1 RAF1 PVALEF PVALEF PRKCB PRKCB AKT2 AKT2 CAMK2D CAMK2D CAMK2B CAMK2B CDKN1A CDKN1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRASKRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CALM3Calmodulin 1; Belongs to the calmodulin family. (149 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (476 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
ENSPANP00000009247Uncharacterized protein. (583 aa)
POLKDNA polymerase kappa. (870 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1161 aa)
TPTE2Uncharacterized protein. (550 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
PIK3R2Uncharacterized protein. (721 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
ARSIArylsulfatase family member I. (569 aa)
ENSPANP00000001773Uncharacterized protein. (189 aa)
E2F2E2F transcription factor 2. (438 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
SHC2Uncharacterized protein. (567 aa)
HRASUncharacterized protein. (189 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
CSDE1Cold shock domain containing E1. (844 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
CEP152Centrosomal protein 152. (1706 aa)
SHC4SHC adaptor protein 4. (630 aa)
CALML4Calmodulin like 4. (194 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
CALM1Calmodulin 1. (149 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
E2F1E2F transcription factor 1. (423 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
ERASES cell expressed Ras. (233 aa)
RB1RB transcriptional corepressor 1. (889 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
SHC3SHC adaptor protein 3. (598 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID; Belongs to the protein kinase superfamily. (357 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (556 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (701 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CDKN2BUncharacterized protein. (173 aa)
ENSPANP00000022457Uncharacterized protein. (208 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (176 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CALM2Calmodulin 2. (149 aa)
ENSPANP00000030371Uncharacterized protein; Belongs to the calmodulin family. (128 aa)
E2F3E2F transcription factor 3. (460 aa)
ENSPANP00000033457Uncharacterized protein; Belongs to the calmodulin family. (99 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
CALML6Calmodulin like 6. (181 aa)
SHC1SHC adaptor protein 1. (601 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
TGFATransforming growth factor alpha. (166 aa)
IGF1Insulin like growth factor 1. (208 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (385 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
RAF1Uncharacterized protein. (668 aa)
PVALEFParvalbumin like EF-hand containing. (133 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (533 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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