STRINGSTRING
ENSPANP00000009247 ENSPANP00000009247 NFKB1 NFKB1 CREB3L2 CREB3L2 HSP90B1 HSP90B1 KRAS KRAS AKT2 AKT2 RELA RELA ENSPANP00000044012 ENSPANP00000044012 ENSPANP00000043785 ENSPANP00000043785 ENSPANP00000042915 ENSPANP00000042915 ENSPANP00000042482 ENSPANP00000042482 RAF1 RAF1 ENSPANP00000041894 ENSPANP00000041894 CREB3L4 CREB3L4 ENSPANP00000039827 ENSPANP00000039827 CDK2 CDK2 IKBKB IKBKB ENSPANP00000039260 ENSPANP00000039260 MAP2K2 MAP2K2 IGF1 IGF1 ENSPANP00000038105 ENSPANP00000038105 NKX2-3 NKX2-3 ERBB2 ERBB2 TGFA TGFA IGF1R IGF1R ENSPANP00000035911 ENSPANP00000035911 ENSPANP00000035354 ENSPANP00000035354 LEF1 LEF1 PIK3CB PIK3CB TP53 TP53 E2F3 E2F3 ERG ERG NFKBIA NFKBIA TCF7L2 TCF7L2 GSK3B GSK3B CREB3L1 CREB3L1 MAPK1 MAPK1 PLAT PLAT ENSPANP00000024626 ENSPANP00000024626 ENSPANP00000024582 ENSPANP00000024582 CDKN1B CDKN1B FGFR2 FGFR2 MAP2K1 MAP2K1 ENSPANP00000021624 ENSPANP00000021624 TCF7 TCF7 CHUK CHUK PTEN PTEN PLAU PLAU PDGFA PDGFA ZEB1 ZEB1 CREB3 CREB3 BRAF BRAF MDM2 MDM2 RB1 RB1 ERAS ERAS SRD5A2 SRD5A2 MMP9 MMP9 SOS1 SOS1 SOS2 SOS2 E2F1 E2F1 ETV5 ETV5 IL1R2 IL1R2 SPINT1 SPINT1 GRB2 GRB2 MTOR MTOR PDGFC PDGFC PIK3CD PIK3CD CREBBP CREBBP EP300 EP300 ATF4 ATF4 PDGFB PDGFB AKT1 AKT1 HSP90AA1 HSP90AA1 TMPRSS2 TMPRSS2 HSP90AB1 HSP90AB1 CDKN1A CDKN1A MAPK3 MAPK3 INSRR INSRR NRAS NRAS CSDE1 CSDE1 KLK3 KLK3 CCND1 CCND1 BAD BAD HRAS HRAS PIK3R1 PIK3R1 E2F2 E2F2 BCL2 BCL2 ENSPANP00000001773 ENSPANP00000001773 PPP1R14B PPP1R14B PIK3R3 PIK3R3 AKT3 AKT3 CREB5 CREB5 CREB1 CREB1 FGFR1 FGFR1 CASP9 CASP9 TCF7L1 TCF7L1 INS INS PDPK1 PDPK1 ARAF ARAF EGFR EGFR CCNE2 CCNE2 PIK3CA PIK3CA CTNNB1 CTNNB1 PDGFD PDGFD AR AR GSTP1 GSTP1 MMP3 MMP3 PDGFRA PDGFRA PIK3R2 PIK3R2 CREB3L3 CREB3L3 CCNE1 CCNE1 ENSPANP00000007612 ENSPANP00000007612 PDGFRB PDGFRB MMP10 MMP10 FOXO1 FOXO1 TPTE2 TPTE2 NKX3-1 NKX3-1 EGF EGF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPANP00000009247Uncharacterized protein. (583 aa)
NFKB1Nuclear factor kappa B subunit 1. (977 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
HSP90B1Heat shock protein 90 beta family member 1. (815 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RELARELA proto-oncogene, NF-kB subunit. (476 aa)
ENSPANP00000044012Uncharacterized protein. (190 aa)
ENSPANP00000043785Uncharacterized protein. (385 aa)
ENSPANP00000042915HATPase_c domain-containing protein. (401 aa)
ENSPANP00000042482Uncharacterized protein. (406 aa)
RAF1Uncharacterized protein. (668 aa)
ENSPANP00000041894Uncharacterized protein. (718 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (422 aa)
ENSPANP00000039827HATPase_c domain-containing protein. (427 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (776 aa)
ENSPANP00000039260Uncharacterized protein. (117 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (385 aa)
IGF1Insulin like growth factor 1. (208 aa)
ENSPANP00000038105HATPase_c domain-containing protein. (598 aa)
NKX2-3NK2 homeobox 3. (365 aa)
ERBB2Receptor protein-tyrosine kinase. (1399 aa)
TGFATransforming growth factor alpha. (166 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
ENSPANP00000035911Protein kinase domain-containing protein. (137 aa)
ENSPANP00000035354Uncharacterized protein. (273 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
E2F3E2F transcription factor 3. (460 aa)
ERGETS transcription factor ERG. (486 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
TCF7L2Transcription factor 7 like 2. (529 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (562 aa)
ENSPANP00000024626Uncharacterized protein. (82 aa)
ENSPANP00000024582Uncharacterized protein. (147 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ENSPANP00000021624BZIP domain-containing protein. (322 aa)
TCF7Transcription factor 7. (480 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PLAUPlasminogen activator, urokinase. (433 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1125 aa)
CREB3cAMP responsive element binding protein 3. (372 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa)
RB1RB transcriptional corepressor 1. (889 aa)
ERASES cell expressed Ras. (233 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
E2F1E2F transcription factor 1. (423 aa)
ETV5ETS variant 5. (510 aa)
IL1R2Interleukin 1 receptor type 2. (398 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (513 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
CREBBPCREB binding protein. (2442 aa)
EP300E1A binding protein p300. (2427 aa)
ATF4Activating transcription factor 4. (351 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (831 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (529 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
INSRRTyrosine-protein kinase receptor. (1301 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CSDE1Cold shock domain containing E1. (844 aa)
KLK3Prostate-specific antigen; Belongs to the peptidase S1 family. (261 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
BADBCL2 associated agonist of cell death. (168 aa)
HRASUncharacterized protein. (189 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
E2F2E2F transcription factor 2. (438 aa)
BCL2BCL2 apoptosis regulator. (238 aa)
ENSPANP00000001773Uncharacterized protein. (189 aa)
PPP1R14BUncharacterized protein. (207 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
FGFR1Fibroblast growth factor receptor. (853 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (416 aa)
TCF7L1Transcription factor 7 like 1. (589 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (347 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CTNNB1Catenin beta 1. (781 aa)
PDGFDPlatelet derived growth factor D. (303 aa)
ARAndrogen receptor. (896 aa)
GSTP1Uncharacterized protein; Belongs to the GST superfamily. (246 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
PIK3R2Uncharacterized protein. (721 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (461 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
ENSPANP00000007612Uncharacterized protein. (190 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
MMP10Matrix metallopeptidase 10. (476 aa)
FOXO1Forkhead box O1. (655 aa)
TPTE2Uncharacterized protein. (550 aa)
NKX3-1NK3 homeobox 1. (232 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1161 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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