STRINGSTRING
GADD45G GADD45G SUFU SUFU HHIP HHIP BMP2 BMP2 TP53 TP53 LEF1 LEF1 BAX BAX WNT8B WNT8B GLI3 GLI3 WNT9A WNT9A APC APC GLI1 GLI1 TCF7L1 TCF7L1 WNT4 WNT4 FZD4 FZD4 CTNNB1 CTNNB1 WNT5A WNT5A WNT10B WNT10B WNT7A WNT7A DVL3 DVL3 FZD3 FZD3 WNT2 WNT2 DDB2 DDB2 WNT11 WNT11 WNT8A WNT8A WNT2B WNT2B FZD7 FZD7 WNT16 WNT16 GADD45A GADD45A WNT5B WNT5B POLK POLK FZD5 FZD5 FZD9 FZD9 FZD10 FZD10 WNT6 WNT6 APC2 APC2 CDKN1A CDKN1A AXIN1 AXIN1 KIF7 KIF7 WNT3A WNT3A WNT10A WNT10A AXIN2 AXIN2 GLI2 GLI2 SMO SMO BMP4 BMP4 SHH SHH WNT1 WNT1 FZD6 FZD6 PTCH1 PTCH1 DVL2 DVL2 FZD8 FZD8 FZD2 FZD2 WNT9B WNT9B WNT3 WNT3 PTCH2 PTCH2 TCF7 TCF7 ENSPANP00000022457 ENSPANP00000022457 GADD45B GADD45B GSK3B GSK3B KIF27 KIF27 WNT7B WNT7B TCF7L2 TCF7L2 DVL1 DVL1 BAK1 BAK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (526 aa)
HHIPHedgehog interacting protein. (700 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
GLI3GLI family zinc finger 3. (1580 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
APCAPC regulator of WNT signaling pathway. (2871 aa)
GLI1GLI family zinc finger 1. (1106 aa)
TCF7L1Transcription factor 7 like 1. (589 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
CTNNB1Catenin beta 1. (781 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
POLKDNA polymerase kappa. (870 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
APC2APC regulator of WNT signaling pathway 2. (2301 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
AXIN1Axin 1, isoform 1 (Predicted). (867 aa)
KIF7Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1343 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
AXIN2Axin 2. (844 aa)
GLI2GLI family zinc finger 2. (1552 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
BMP4Bone morphogenetic protein 4, isoform 3 (Predicted). (408 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (456 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa)
PTCH1Patched 1. (1452 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (680 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (550 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
PTCH2Patched 2. (1203 aa)
TCF7Transcription factor 7. (480 aa)
ENSPANP00000022457Uncharacterized protein. (208 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (176 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
KIF27Kinesin family member 27; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1401 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
TCF7L2Transcription factor 7 like 2. (529 aa)
DVL1Dishevelled segment polarity protein 1. (684 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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