STRINGSTRING
HGF HGF PPP1R14B PPP1R14B FHIT FHIT ENSPANP00000001773 ENSPANP00000001773 E2F2 E2F2 PIK3R1 PIK3R1 HRAS HRAS BAD BAD CCND1 CCND1 CSDE1 CSDE1 MET MET STAT5A STAT5A MAPK1 MAPK1 ENSPANP00000024626 ENSPANP00000024626 ENSPANP00000024582 ENSPANP00000024582 ALK ALK GADD45B GADD45B ENSPANP00000022457 ENSPANP00000022457 CDKN2B CDKN2B MAP2K1 MAP2K1 PRKCG PRKCG GADD45G GADD45G KRAS KRAS AKT2 AKT2 PRKCB PRKCB STAT5B STAT5B RAF1 RAF1 BAK1 BAK1 MAP2K2 MAP2K2 STAT3 STAT3 ERBB2 ERBB2 TGFA TGFA BAX BAX ENSPANP00000035911 ENSPANP00000035911 RARB RARB PIK3CB PIK3CB TP53 TP53 E2F3 E2F3 RXRA RXRA BRAF BRAF RB1 RB1 ERAS ERAS PLCG1 PLCG1 STK4 STK4 SOS1 SOS1 SOS2 SOS2 E2F1 E2F1 PRKCA PRKCA LTK LTK GRB2 GRB2 PIK3CD PIK3CD AKT1 AKT1 CDKN1A CDKN1A MAPK3 MAPK3 RXRB RXRB CDK6 CDK6 NRAS NRAS PLCG2 PLCG2 ENSPANP00000009247 ENSPANP00000009247 POLK POLK EGF EGF GADD45A GADD45A CDK4 CDK4 ENSPANP00000007612 ENSPANP00000007612 PIK3R2 PIK3R2 DDB2 DDB2 JAK3 JAK3 RASSF1 RASSF1 PIK3CA PIK3CA FOXO3 FOXO3 RXRG RXRG EML4 EML4 EGFR EGFR ARAF ARAF PDPK1 PDPK1 CASP9 CASP9 AKT3 AKT3 PIK3R3 PIK3R3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (788 aa)
PPP1R14BUncharacterized protein. (207 aa)
FHITBis(5'-adenosyl)-triphosphatase. (149 aa)
ENSPANP00000001773Uncharacterized protein. (189 aa)
E2F2E2F transcription factor 2. (438 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
HRASUncharacterized protein. (189 aa)
BADBCL2 associated agonist of cell death. (168 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
CSDE1Cold shock domain containing E1. (844 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1404 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ENSPANP00000024626Uncharacterized protein. (82 aa)
ENSPANP00000024582Uncharacterized protein. (147 aa)
ALKTyrosine-protein kinase receptor. (1620 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (176 aa)
ENSPANP00000022457Uncharacterized protein. (208 aa)
CDKN2BUncharacterized protein. (173 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (701 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
STAT5BSignal transducer and activator of transcription. (791 aa)
RAF1Uncharacterized protein. (668 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (385 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
ERBB2Receptor protein-tyrosine kinase. (1399 aa)
TGFATransforming growth factor alpha. (166 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
ENSPANP00000035911Protein kinase domain-containing protein. (137 aa)
RARBRetinoic acid receptor beta. (448 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
E2F3E2F transcription factor 3. (460 aa)
RXRARetinoid X receptor alpha. (522 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (763 aa)
RB1RB transcriptional corepressor 1. (889 aa)
ERASES cell expressed Ras. (233 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
STK4Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] (487 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
E2F1E2F transcription factor 1. (423 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
LTKTyrosine-protein kinase receptor. (864 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
RXRBRetinoid X receptor beta. (533 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
ENSPANP00000009247Uncharacterized protein. (583 aa)
POLKDNA polymerase kappa. (870 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1161 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
ENSPANP00000007612Uncharacterized protein. (190 aa)
PIK3R2Uncharacterized protein. (721 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
JAK3Tyrosine-protein kinase. (1147 aa)
RASSF1Ras association domain family member 1. (344 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FOXO3Forkhead box O3. (672 aa)
RXRGRetinoid X receptor gamma. (463 aa)
EML4EMAP like 4. (990 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (347 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (416 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
Your Current Organism:
Papio anubis
NCBI taxonomy Id: 9555
Other names: Anubis baboon, Doguera baboon, Kenya baboon, P. anubis, Papio cynocephalus anubis, Papio doguera, Papio hamadryas anubis, Papio hamadryas doguera, baboon, olive baboon
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