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| | LRP5 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa) |
| | DVL1 | Dishevelled segment polarity protein 1. (684 aa) |
| | CTNNA2 | Catenin alpha 2. (953 aa) |
| | RXRA | Retinoid X receptor alpha. (522 aa) |
| | GAB1 | GRB2 associated binding protein 1. (790 aa) |
| | E2F3 | E2F transcription factor 3. (460 aa) |
| | FGF16 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1073 aa) |
| | RARB | Retinoic acid receptor beta. (448 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (414 aa) |
| | SHC1 | SHC adaptor protein 1. (601 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (203 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog. (472 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1399 aa) |
| | WNT8B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | WNT9A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | APC | APC regulator of WNT signaling pathway. (2871 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (385 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (211 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | ENSPANP00000039936 | Uncharacterized protein. (85 aa) |
| | CSNK1A1L | Casein kinase 1 alpha 1 like; Belongs to the protein kinase superfamily. (318 aa) |
| | CDX2 | Caudal type homeobox 2. (313 aa) |
| | RAF1 | Uncharacterized protein. (668 aa) |
| | FGF17 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa) |
| | ENSPANP00000045247 | Protein kinase domain-containing protein. (214 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | CSNK1A1 | Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily. (365 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1152 aa) |
| | CTNNA1 | Catenin alpha 1. (906 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | HGF | Hepatocyte growth factor; Belongs to the peptidase S1 family. (788 aa) |
| | PIK3R3 | Phosphoinositide-3-kinase regulatory subunit 3. (461 aa) |
| | ENSPANP00000001773 | Uncharacterized protein. (189 aa) |
| | BCL2 | BCL2 apoptosis regulator. (238 aa) |
| | E2F2 | E2F transcription factor 2. (438 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | CDH1 | Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (882 aa) |
| | SHC2 | Uncharacterized protein. (567 aa) |
| | HRAS | Uncharacterized protein. (189 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | FGF4 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | CSDE1 | Cold shock domain containing E1. (844 aa) |
| | TCF7L1 | Transcription factor 7 like 1. (589 aa) |
| | MLH1 | MutL homolog 1. (756 aa) |
| | FGF21 | Fibroblast growth factor 21; Belongs to the heparin-binding growth factors family. (174 aa) |
| | WNT4 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | ARAF | A-Raf proto-oncogene, serine/threonine kinase. (606 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1210 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (404 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa) |
| | RXRG | Retinoid X receptor gamma. (463 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | CTNNB1 | Catenin beta 1. (781 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | WNT7A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa) |
| | DVL3 | Dishevelled segment polarity protein 3. (716 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | CDH17 | Cadherin 17. (832 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | WNT2 | Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa) |
| | DDB2 | Damage specific DNA binding protein 2. (427 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
| | WNT8A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | PIK3R2 | Uncharacterized protein. (721 aa) |
| | WNT2B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (410 aa) |
| | LRP6 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa) |
| | RPS6KB2 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa) |
| | FGF1 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa) |
| | FZD7 | Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa) |
| | WNT16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | GADD45A | Growth arrest and DNA damage inducible alpha. (165 aa) |
| | WNT5B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1161 aa) |
| | POLK | DNA polymerase kappa. (870 aa) |
| | FZD5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa) |
| | ENSPANP00000009247 | Uncharacterized protein. (583 aa) |
| | FGF5 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa) |
| | REG4 | Regenerating family member 4. (158 aa) |
| | FZD9 | Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa) |
| | FZD10 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa) |
| | WNT6 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | APC2 | APC regulator of WNT signaling pathway 2. (2301 aa) |
| | RXRB | Retinoid X receptor beta. (533 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | AXIN1 | Axin 1, isoform 1 (Predicted). (867 aa) |
| | CEP152 | Centrosomal protein 152. (1706 aa) |
| | SHC4 | SHC adaptor protein 4. (630 aa) |
| | GALK2 | Galactokinase 2. (458 aa) |
| | FGF7 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (425 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | FGF6 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa) |
| | FGF22 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa) |
| | FGF20 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa) |
| | FGF18 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa) |
| | WNT10A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (217 aa) |
| | AXIN2 | Axin 2. (844 aa) |
| | E2F1 | E2F transcription factor 1. (423 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (456 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1332 aa) |
| | FGF19 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa) |
| | FGF3 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa) |
| | FGF23 | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa) |
| | REG3A | Regenerating family member 3 alpha. (175 aa) |
| | REG3G | Regenerating family member 3 gamma. (175 aa) |
| | ERAS | ES cell expressed Ras. (233 aa) |
| | FGF2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa) |
| | RB1 | RB transcriptional corepressor 1. (889 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | BRAF | B-Raf proto-oncogene, serine/threonine kinase. (763 aa) |
| | FZD6 | Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (706 aa) |
| | SHC3 | SHC adaptor protein 3. (598 aa) |
| | GADD45G | Growth arrest and DNA damage inducible gamma. (159 aa) |
| | DVL2 | Dishevelled segment polarity protein 2. (736 aa) |
| | FZD8 | Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (680 aa) |
| | CTNNA3 | Catenin alpha 3. (895 aa) |
| | JUP | Junction plakoglobin. (745 aa) |
| | FRAT1 | FRAT regulator of WNT signaling pathway 1. (279 aa) |
| | FRAT2 | FRAT regulator of WNT signaling pathway 2. (233 aa) |
| | FZD2 | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (550 aa) |
| | WNT9B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | FGF8 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa) |
| | TCF7 | Transcription factor 7. (480 aa) |
| | ENSPANP00000021910 | Uncharacterized protein. (822 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | ENSPANP00000022457 | Uncharacterized protein. (208 aa) |
| | GADD45B | Growth arrest and DNA damage inducible beta. (176 aa) |
| | FGFR2 | Fibroblast growth factor receptor. (840 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (198 aa) |
| | FGF9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) |
| | WNT7B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | TCF7L2 | Transcription factor 7 like 2. (529 aa) |
| | MET | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1404 aa) |
