(32 nodes) Mixed, incl. Spindle elongation, and Chromosome passenger complex network (Mandrillus leucophaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KIF23	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (960 aa)
	ESPL1	Extra spindle pole bodies like 1, separase. (2100 aa)
	MELK	Non-specific serine/threonine protein kinase. (651 aa)
	KIF14	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1649 aa)
	ASPM	Abnormal spindle microtubule assembly. (3476 aa)
	DLGAP5	DLG associated protein 5. (851 aa)
	CENPE	Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2700 aa)
	AURKC	Aurora kinase C; Belongs to the protein kinase superfamily. (309 aa)
	CEP55	Centrosomal protein 55. (458 aa)
	ARHGAP11A	Rho GTPase activating protein 11A. (1023 aa)
	KIF18A	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (533 aa)
	TTK	TTK protein kinase. (855 aa)
	ECT2	Epithelial cell transforming 2. (917 aa)
	PBK	PDZ binding kinase. (334 aa)
	KIF20A	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (890 aa)
	CDCA8	Cell division cycle associated 8. (280 aa)
	BIRC5	Uncharacterized protein. (147 aa)
	PRC1	Protein regulator of cytokinesis 1. (624 aa)
	LOC105532146	Uncharacterized protein. (434 aa)
	KIF15	Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1388 aa)
	CENPF	Centromere protein F. (3113 aa)
	FOXM1	Forkhead box M1. (770 aa)
	CNTD2	Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (198 aa)
	AURKB	Aurora kinase B; Belongs to the protein kinase superfamily. (345 aa)
	RACGAP1	Rac GTPase activating protein 1. (632 aa)
	TOP2A	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1531 aa)
	KIF11	Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1056 aa)
	KIF2C	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (725 aa)
	ENSMLEP00000036889	Uncharacterized protein. (182 aa)
	CKAP2	Cytoskeleton associated protein 2. (683 aa)
	INCENP	Inner centromere protein. (897 aa)
	LOC105537660	Uncharacterized protein. (140 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP11A	ASPM	ENSMLEP00000011980	ENSMLEP00000007854	Rho GTPase activating protein 11A.	Abnormal spindle microtubule assembly.	0.874
ARHGAP11A	AURKB	ENSMLEP00000011980	ENSMLEP00000030453	Rho GTPase activating protein 11A.	Aurora kinase B; Belongs to the protein kinase superfamily.	0.465
ARHGAP11A	AURKC	ENSMLEP00000011980	ENSMLEP00000010196	Rho GTPase activating protein 11A.	Aurora kinase C; Belongs to the protein kinase superfamily.	0.465
ARHGAP11A	BIRC5	ENSMLEP00000011980	ENSMLEP00000021285	Rho GTPase activating protein 11A.	Uncharacterized protein.	0.729
ARHGAP11A	CDCA8	ENSMLEP00000011980	ENSMLEP00000018559	Rho GTPase activating protein 11A.	Cell division cycle associated 8.	0.853
ARHGAP11A	CENPE	ENSMLEP00000011980	ENSMLEP00000008950	Rho GTPase activating protein 11A.	Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.862
ARHGAP11A	CENPF	ENSMLEP00000011980	ENSMLEP00000025745	Rho GTPase activating protein 11A.	Centromere protein F.	0.869
ARHGAP11A	CEP55	ENSMLEP00000011980	ENSMLEP00000011101	Rho GTPase activating protein 11A.	Centrosomal protein 55.	0.851
ARHGAP11A	CKAP2	ENSMLEP00000011980	ENSMLEP00000039343	Rho GTPase activating protein 11A.	Cytoskeleton associated protein 2.	0.840
ARHGAP11A	CNTD2	ENSMLEP00000011980	ENSMLEP00000027195	Rho GTPase activating protein 11A.	Cyclin N-terminal domain containing 2; Belongs to the cyclin family.	0.453
ARHGAP11A	DLGAP5	ENSMLEP00000011980	ENSMLEP00000008024	Rho GTPase activating protein 11A.	DLG associated protein 5.	0.865
ARHGAP11A	ECT2	ENSMLEP00000011980	ENSMLEP00000013547	Rho GTPase activating protein 11A.	Epithelial cell transforming 2.	0.797
ARHGAP11A	ESPL1	ENSMLEP00000011980	ENSMLEP00000003781	Rho GTPase activating protein 11A.	Extra spindle pole bodies like 1, separase.	0.848
ARHGAP11A	FOXM1	ENSMLEP00000011980	ENSMLEP00000026020	Rho GTPase activating protein 11A.	Forkhead box M1.	0.796
ARHGAP11A	KIF11	ENSMLEP00000011980	ENSMLEP00000033668	Rho GTPase activating protein 11A.	Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.873
ARHGAP11A	KIF14	ENSMLEP00000011980	ENSMLEP00000004975	Rho GTPase activating protein 11A.	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.527
ARHGAP11A	KIF15	ENSMLEP00000011980	ENSMLEP00000023784	Rho GTPase activating protein 11A.	Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.816
ARHGAP11A	KIF18A	ENSMLEP00000011980	ENSMLEP00000012242	Rho GTPase activating protein 11A.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.744
ARHGAP11A	KIF20A	ENSMLEP00000011980	ENSMLEP00000015555	Rho GTPase activating protein 11A.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.854
ARHGAP11A	KIF23	ENSMLEP00000011980	ENSMLEP00000001336	Rho GTPase activating protein 11A.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.726