(8 nodes) DNA replication initiation network (Mandrillus leucophaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PRIM1	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa)
	LOC105554521	DNA_pol_E_B domain-containing protein. (252 aa)
	POLE4	DNA polymerase epsilon 4, accessory subunit. (119 aa)
	POLE3	DNA polymerase epsilon 3, accessory subunit. (147 aa)
	POLA1	DNA polymerase. (1420 aa)
	POLA2	Uncharacterized protein. (548 aa)
	PRIM2	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (509 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2288 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC105554521	POLA1	ENSMLEP00000010506	ENSMLEP00000027581	DNA_pol_E_B domain-containing protein.	DNA polymerase.	0.976
LOC105554521	POLA2	ENSMLEP00000010506	ENSMLEP00000029245	DNA_pol_E_B domain-containing protein.	Uncharacterized protein.	0.937
LOC105554521	POLE	ENSMLEP00000010506	ENSMLEP00000035885	DNA_pol_E_B domain-containing protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.996
LOC105554521	POLE3	ENSMLEP00000010506	ENSMLEP00000018131	DNA_pol_E_B domain-containing protein.	DNA polymerase epsilon 3, accessory subunit.	0.995
LOC105554521	POLE4	ENSMLEP00000010506	ENSMLEP00000011403	DNA_pol_E_B domain-containing protein.	DNA polymerase epsilon 4, accessory subunit.	0.994
LOC105554521	PRIM1	ENSMLEP00000010506	ENSMLEP00000002113	DNA_pol_E_B domain-containing protein.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.958
LOC105554521	PRIM2	ENSMLEP00000010506	ENSMLEP00000030971	DNA_pol_E_B domain-containing protein.	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.	0.963
POLA1	LOC105554521	ENSMLEP00000027581	ENSMLEP00000010506	DNA polymerase.	DNA_pol_E_B domain-containing protein.	0.976
POLA1	POLA2	ENSMLEP00000027581	ENSMLEP00000029245	DNA polymerase.	Uncharacterized protein.	0.999
POLA1	POLE	ENSMLEP00000027581	ENSMLEP00000035885	DNA polymerase.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.996
POLA1	POLE3	ENSMLEP00000027581	ENSMLEP00000018131	DNA polymerase.	DNA polymerase epsilon 3, accessory subunit.	0.985
POLA1	POLE4	ENSMLEP00000027581	ENSMLEP00000011403	DNA polymerase.	DNA polymerase epsilon 4, accessory subunit.	0.975
POLA1	PRIM1	ENSMLEP00000027581	ENSMLEP00000002113	DNA polymerase.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.999
POLA1	PRIM2	ENSMLEP00000027581	ENSMLEP00000030971	DNA polymerase.	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.	0.999
POLA2	LOC105554521	ENSMLEP00000029245	ENSMLEP00000010506	Uncharacterized protein.	DNA_pol_E_B domain-containing protein.	0.937
POLA2	POLA1	ENSMLEP00000029245	ENSMLEP00000027581	Uncharacterized protein.	DNA polymerase.	0.999
POLA2	POLE	ENSMLEP00000029245	ENSMLEP00000035885	Uncharacterized protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.996
POLA2	POLE3	ENSMLEP00000029245	ENSMLEP00000018131	Uncharacterized protein.	DNA polymerase epsilon 3, accessory subunit.	0.958
POLA2	POLE4	ENSMLEP00000029245	ENSMLEP00000011403	Uncharacterized protein.	DNA polymerase epsilon 4, accessory subunit.	0.943
POLA2	PRIM1	ENSMLEP00000029245	ENSMLEP00000002113	Uncharacterized protein.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.999