(20 nodes) DNA replication factor A complex, and HDR through Single Strand Annealing (SSA) network (Mandrillus leucophaeus)

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second shell of interactors

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Predicted Interactions

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Your Input:
	ENSMLEP00000006951	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (268 aa)
	CLSPN	Claspin. (1072 aa)
	TOP3B	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa)
	ENSMLEP00000010931	Uncharacterized protein. (79 aa)
	ENSMLEP00000013654	Uncharacterized protein. (83 aa)
	ENSMLEP00000014080	Uncharacterized protein. (103 aa)
	RAD52	RAD52 homolog, DNA repair protein. (400 aa)
	RPA2	Replication protein A2. (356 aa)
	BLM	BLM RecQ like helicase. (1392 aa)
	MEIOB	Meiosis specific with OB-fold. (407 aa)
	FANCM	FA complementation group M. (1935 aa)
	ENSMLEP00000023788	RMI1_N domain-containing protein. (122 aa)
	RPA3	Replication protein A3. (121 aa)
	LOC105541595	RPA_C domain-containing protein. (250 aa)
	WRN	WRN RecQ like helicase. (1404 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (595 aa)
	TDRD3	Tudor domain-containing protein. (405 aa)
	ATRIP	ATR interacting protein. (772 aa)
	TOP3A	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa)
	EXD2	Exonuclease 3'-5' domain containing 2. (620 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATRIP	BLM	ENSMLEP00000034224	ENSMLEP00000017525	ATR interacting protein.	BLM RecQ like helicase.	0.638
ATRIP	CLSPN	ENSMLEP00000034224	ENSMLEP00000007843	ATR interacting protein.	Claspin.	0.795
ATRIP	ENSMLEP00000006951	ENSMLEP00000034224	ENSMLEP00000006951	ATR interacting protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.928
ATRIP	ENSMLEP00000010931	ENSMLEP00000034224	ENSMLEP00000010931	ATR interacting protein.	Uncharacterized protein.	0.661
ATRIP	ENSMLEP00000013654	ENSMLEP00000034224	ENSMLEP00000013654	ATR interacting protein.	Uncharacterized protein.	0.634
ATRIP	ENSMLEP00000014080	ENSMLEP00000034224	ENSMLEP00000014080	ATR interacting protein.	Uncharacterized protein.	0.652
ATRIP	ENSMLEP00000023788	ENSMLEP00000034224	ENSMLEP00000023788	ATR interacting protein.	RMI1_N domain-containing protein.	0.580
ATRIP	EXD2	ENSMLEP00000034224	ENSMLEP00000040231	ATR interacting protein.	Exonuclease 3'-5' domain containing 2.	0.613
ATRIP	FANCM	ENSMLEP00000034224	ENSMLEP00000023084	ATR interacting protein.	FA complementation group M.	0.974
ATRIP	LOC105541595	ENSMLEP00000034224	ENSMLEP00000024617	ATR interacting protein.	RPA_C domain-containing protein.	0.697
ATRIP	MEIOB	ENSMLEP00000034224	ENSMLEP00000022929	ATR interacting protein.	Meiosis specific with OB-fold.	0.829
ATRIP	RAD52	ENSMLEP00000034224	ENSMLEP00000014779	ATR interacting protein.	RAD52 homolog, DNA repair protein.	0.781
ATRIP	RPA1	ENSMLEP00000034224	ENSMLEP00000029121	ATR interacting protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.928
ATRIP	RPA2	ENSMLEP00000034224	ENSMLEP00000014816	ATR interacting protein.	Replication protein A2.	0.764
ATRIP	RPA3	ENSMLEP00000034224	ENSMLEP00000024293	ATR interacting protein.	Replication protein A3.	0.696
ATRIP	TDRD3	ENSMLEP00000034224	ENSMLEP00000031083	ATR interacting protein.	Tudor domain-containing protein.	0.580
ATRIP	TOP3A	ENSMLEP00000034224	ENSMLEP00000038584	ATR interacting protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.715
ATRIP	TOP3B	ENSMLEP00000034224	ENSMLEP00000009473	ATR interacting protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.555
ATRIP	WRN	ENSMLEP00000034224	ENSMLEP00000028175	ATR interacting protein.	WRN RecQ like helicase.	0.974
BLM	ATRIP	ENSMLEP00000017525	ENSMLEP00000034224	BLM RecQ like helicase.	ATR interacting protein.	0.638