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SLC8A1 SLC8A1 KCNN2 KCNN2 SCN4A SCN4A CLDN19 CLDN19 KCNQ1 KCNQ1 KCNH7 KCNH7 GJD2 GJD2 P2RX7 P2RX7 CHRNA1 CHRNA1 ANK3 ANK3 CACNA2D1 CACNA2D1 KCND3 KCND3 GPER1 GPER1 SCN2B SCN2B KCNJ5 KCNJ5 NRCAM NRCAM P2RX3 P2RX3 KCNH6 KCNH6 CLCN1 CLCN1 KCNIP2 KCNIP2 SNTA1 SNTA1 TRPM4 TRPM4 FGF12 FGF12 PKP2 PKP2 SCN7A SCN7A CACNA1I CACNA1I CHRNB4 CHRNB4 SCN2A SCN2A SCN11A SCN11A GLRA1 GLRA1 ENSMLEP00000027370 ENSMLEP00000027370 CACNA1C CACNA1C SCN5A SCN5A KCNMB2 KCNMB2 KCNJ3 KCNJ3 FKBP1B FKBP1B AKAP6 AKAP6 YWHAH YWHAH CACNA1G CACNA1G SCN1B SCN1B CAV3 CAV3 CACNA1D CACNA1D GNA15 GNA15 CACNB2 CACNB2 YWHAE YWHAE ANK2 ANK2 HCN4 HCN4 SCN8A SCN8A CACNB4 CACNB4 SCN4B SCN4B KCNMB3 KCNMB3 CNTNAP1 CNTNAP1 GNA14 GNA14 KCND2 KCND2 GRIK2 GRIK2 MYH14 MYH14 SCN1A SCN1A SCN10A SCN10A RYR2 RYR2 PMP22 PMP22 GNAQ GNAQ KCNMB4 KCNMB4 KCNA5 KCNA5 KCNJ2 KCNJ2 SCN9A SCN9A ENSMLEP00000006859 ENSMLEP00000006859 LOC105555622 LOC105555622 CACNA1H CACNA1H MTOR MTOR KCNJ8 KCNJ8 P2RX1 P2RX1 DMD DMD SLC4A3 SLC4A3 P2RX4 P2RX4 NTRK2 NTRK2 SCN3A SCN3A KCNA1 KCNA1 NUP155 NUP155 KCNE4 KCNE4 KCNE3 KCNE3 KCNH2 KCNH2 GNA11 GNA11 KCNC2 KCNC2 AKAP7 AKAP7 KCNA2 KCNA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
KCNN2Potassium calcium-activated channel subfamily N member 2. (540 aa)
SCN4ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1836 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (592 aa)
KCNH7Potassium voltage-gated channel subfamily H member 7. (1195 aa)
GJD2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (321 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
CHRNA1Cholinergic receptor nicotinic alpha 1 subunit. (472 aa)
ANK3Ankyrin 3. (4377 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1018 aa)
KCND3Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family. (655 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (400 aa)
SCN2BSodium voltage-gated channel beta subunit 2. (215 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
NRCAMNeuronal cell adhesion molecule. (1304 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (397 aa)
KCNH6Potassium voltage-gated channel subfamily H member 6. (994 aa)
CLCN1Chloride voltage-gated channel 1. (966 aa)
KCNIP2Potassium voltage-gated channel interacting protein 2. (285 aa)
SNTA1Syntrophin alpha 1. (463 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (954 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
PKP2Plakophilin 2. (757 aa)
SCN7ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1681 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2080 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit. (442 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2005 aa)
SCN11ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1796 aa)
GLRA1Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
ENSMLEP00000027370Uncharacterized protein. (78 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2169 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1987 aa)
KCNMB2KcnmB2_inactiv domain-containing protein. (235 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
FKBP1BPeptidylprolyl isomerase. (95 aa)
AKAP6A-kinase anchoring protein 6. (2319 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (223 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2360 aa)
SCN1BSodium voltage-gated channel beta subunit 1. (236 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
GNA15G protein subunit alpha 15. (374 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
ANK2Ankyrin 2. (3938 aa)
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1035 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1980 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (490 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (228 aa)
KCNMB3Potassium calcium-activated channel subfamily M regulatory beta subunit 3. (270 aa)
CNTNAP1Contactin associated protein 1. (1199 aa)
GNA14G protein subunit alpha 14. (355 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (630 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1912 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1959 aa)
RYR2Ryanodine receptor 2. (4862 aa)
PMP22Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family. (160 aa)
GNAQG protein subunit alpha q. (313 aa)
KCNMB4Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (210 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (605 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (427 aa)
SCN9ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1977 aa)
ENSMLEP0000000685914_3_3 domain-containing protein; Belongs to the 14-3-3 family. (196 aa)
LOC105555622Uncharacterized protein. (3074 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2170 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
KCNJ8Potassium voltage-gated channel subfamily J member 8. (424 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
DMDZZ-type domain-containing protein. (635 aa)
SLC4A3Anion exchange protein. (1259 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (359 aa)
NTRK2Tyrosine-protein kinase receptor. (724 aa)
SCN3ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2000 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
NUP155Nucleoporin 155. (1449 aa)
KCNE4Potassium voltage-gated channel subfamily E regulatory subunit 4. (220 aa)
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (103 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (991 aa)
GNA11G protein subunit alpha 11. (307 aa)
KCNC2Potassium voltage-gated channel subfamily C member 2; Belongs to the potassium channel family. (638 aa)
AKAP7A-kinase anchoring protein 7. (348 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (356 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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