73 items (Mandrillus leucophaeus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ACKR3	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	AP2A1	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (912 aa)
	SORT1	Sortilin. (676 aa)
	CTTN	Cortactin. (550 aa)
	STON1	Stonin-1; May be involved in the endocytic machinery. (735 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1032 aa)
	INPP5F	Inositol polyphosphate-5-phosphatase F. (1122 aa)
	AP1S2	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
	AP1S1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
	NUMB	NUMB endocytic adaptor protein. (652 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
	SGIP1	SH3 domain GRB2 like endophilin interacting protein 1. (859 aa)
	EPS15	Epidermal growth factor receptor pathway substrate 15. (859 aa)
	EPN1	Epsin 1. (662 aa)
	ATAT1	Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (423 aa)
	SLC18A3	Solute carrier family 18 member A3. (518 aa)
	FCHO1	FCH domain only 1. (850 aa)
	NECAP2	NECAP endocytosis associated 2. (273 aa)
	LRP2	LDL receptor related protein 2. (4655 aa)
	SLC2A4	Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
	AP2A2	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (939 aa)
	LDLR	Low density lipoprotein receptor. (860 aa)
	ENSMLEP00000012429	EH domain-containing protein. (100 aa)
	CLTC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1679 aa)
	ARRB2	Arrestin beta 2. (478 aa)
	CUBN	Cubilin. (3628 aa)
	LRP12	LDL receptor related protein 12. (859 aa)
	DNM2	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (810 aa)
	ENSMLEP00000016003	Uncharacterized protein. (92 aa)
	VLDLR	Very low density lipoprotein receptor. (873 aa)
	CLTCL1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1572 aa)
	TFRC	Transferrin receptor. (679 aa)
	OCRL	OCRL inositol polyphosphate-5-phosphatase. (888 aa)
	ITSN2	Intersectin 2. (1697 aa)
	ITSN1	Intersectin 1. (1719 aa)
	AP2S1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
	CLHC1	Clathrin heavy chain linker domain-containing protein 1. (526 aa)
	CLTA	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
	TF	Transferrin; Belongs to the transferrin family. (698 aa)
	FNBP1	Formin binding protein 1. (523 aa)
	CDHR5	Cadherin related family member 5. (750 aa)
	SPHK1	Sphingosine kinase 1. (470 aa)
	AP1S3	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (164 aa)
	ENSMLEP00000025432	B2-adapt-app_C domain-containing protein. (224 aa)
	AP2M1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (458 aa)
	SYNJ1	Synaptojanin 1. (1614 aa)
	SH3BP4	SH3 domain binding protein 4. (963 aa)
	RAMP2	Receptor activity modifying protein 2. (216 aa)
	PICALM	Phosphatidylinositol binding clathrin assembly protein. (674 aa)
	C6orf136	Chromosome 6 open reading frame 136. (291 aa)
	FCHSD2	FCH and double SH3 domains 2. (709 aa)
	ARRB1	Arrestin beta 1. (417 aa)
	ENSMLEP00000029371	Uncharacterized protein. (406 aa)
	SNAP91	Synaptosome associated protein 91. (872 aa)
	ENSMLEP00000031244	Uncharacterized protein. (85 aa)
	APP	Amyloid beta precursor protein. (772 aa)
	LRP1	LDL receptor related protein 1. (4546 aa)
	RAB35	RAB35, member RAS oncogene family. (319 aa)
	MYO6	Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1290 aa)
	CLTB	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (203 aa)
	EPN3	Epsin 3. (632 aa)
	AP2B1	AP complex subunit beta. (942 aa)
	FCHO2	FCH domain only 2. (815 aa)
	HIP1R	Huntingtin interacting protein 1 related. (1063 aa)
	AAK1	AP2 associated kinase 1. (962 aa)
	LRP3	LDL receptor related protein 3. (788 aa)
	DAB2	DAB adaptor protein 2. (770 aa)
	DNM1L	Dynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (734 aa)
	LRP10	LDL receptor related protein 10. (716 aa)
	REPS1	RALBP1 associated Eps domain containing 1. (796 aa)
	DGKD	Diacylglycerol kinase. (1181 aa)
	AMN	Amnion associated transmembrane protein. (296 aa)
	SELE	Selectin E. (610 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AAK1	AP2A1	ENSMLEP00000037033	ENSMLEP00000000201	AP2 associated kinase 1.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.667
AAK1	AP2B1	ENSMLEP00000037033	ENSMLEP00000036489	AP2 associated kinase 1.	AP complex subunit beta.	0.686
AAK1	AP2M1	ENSMLEP00000037033	ENSMLEP00000026079	AP2 associated kinase 1.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.872
AAK1	AP2S1	ENSMLEP00000037033	ENSMLEP00000020033	AP2 associated kinase 1.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.808
AAK1	CLHC1	ENSMLEP00000037033	ENSMLEP00000020880	AP2 associated kinase 1.	Clathrin heavy chain linker domain-containing protein 1.	0.469
AAK1	CLTA	ENSMLEP00000037033	ENSMLEP00000022377	AP2 associated kinase 1.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.439
AAK1	CLTB	ENSMLEP00000037033	ENSMLEP00000036176	AP2 associated kinase 1.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.439
AAK1	CLTC	ENSMLEP00000037033	ENSMLEP00000013187	AP2 associated kinase 1.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.493
AAK1	CLTCL1	ENSMLEP00000037033	ENSMLEP00000017151	AP2 associated kinase 1.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.493
AAK1	ENSMLEP00000012429	ENSMLEP00000037033	ENSMLEP00000012429	AP2 associated kinase 1.	EH domain-containing protein.	0.738
AAK1	ENSMLEP00000025432	ENSMLEP00000037033	ENSMLEP00000025432	AP2 associated kinase 1.	B2-adapt-app_C domain-containing protein.	0.686
AAK1	ENSMLEP00000029371	ENSMLEP00000037033	ENSMLEP00000029371	AP2 associated kinase 1.	Uncharacterized protein.	0.738
AAK1	EPS15	ENSMLEP00000037033	ENSMLEP00000005817	AP2 associated kinase 1.	Epidermal growth factor receptor pathway substrate 15.	0.812
AAK1	FCHO1	ENSMLEP00000037033	ENSMLEP00000009656	AP2 associated kinase 1.	FCH domain only 1.	0.647
AAK1	FCHO2	ENSMLEP00000037033	ENSMLEP00000036641	AP2 associated kinase 1.	FCH domain only 2.	0.474
AAK1	HIP1R	ENSMLEP00000037033	ENSMLEP00000037018	AP2 associated kinase 1.	Huntingtin interacting protein 1 related.	0.625
AAK1	ITSN1	ENSMLEP00000037033	ENSMLEP00000019264	AP2 associated kinase 1.	Intersectin 1.	0.496
AAK1	ITSN2	ENSMLEP00000037033	ENSMLEP00000019044	AP2 associated kinase 1.	Intersectin 2.	0.693
AAK1	NECAP2	ENSMLEP00000037033	ENSMLEP00000009890	AP2 associated kinase 1.	NECAP endocytosis associated 2.	0.490
AAK1	NUMB	ENSMLEP00000037033	ENSMLEP00000005309	AP2 associated kinase 1.	NUMB endocytic adaptor protein.	0.638