STRINGSTRING
HSDL1 HSDL1 MIF MIF FA2H FA2H CYP3A4 CYP3A4 LOC105552915 LOC105552915 ELOVL1 ELOVL1 HTD2 HTD2 TECR TECR QKI QKI SUGCT SUGCT ALOX15B ALOX15B ENSMLEP00000019669 ENSMLEP00000019669 ALOXE3 ALOXE3 PTGDS PTGDS ENSMLEP00000020563 ENSMLEP00000020563 ALOX5 ALOX5 PECR PECR CD74 CD74 ABCD3 ABCD3 ALOX12B ALOX12B ELOVL7 ELOVL7 ACSM4 ACSM4 ENSMLEP00000023414 ENSMLEP00000023414 LOC105532823 LOC105532823 LIAS LIAS PCCB PCCB ACOT7 ACOT7 PRKAG2 PRKAG2 GSTM2 GSTM2 ABHD1 ABHD1 CYP2C8 CYP2C8 ELOVL4 ELOVL4 HACD1 HACD1 ASAH2 ASAH2 SCD SCD MGLL MGLL LTC4S LTC4S LOC105549919 LOC105549919 PTGES PTGES XBP1 XBP1 ENSMLEP00000030723 ENSMLEP00000030723 HNF1A HNF1A FADS2 FADS2 ACSM5 ACSM5 PTGES2 PTGES2 ENSMLEP00000032489 ENSMLEP00000032489 PRKAG1 PRKAG1 ACSM3 ACSM3 PRKAB2 PRKAB2 ELOVL5 ELOVL5 PRKAA1 PRKAA1 ABCD1 ABCD1 PNPLA8 PNPLA8 ELOVL2 ELOVL2 HSD17B12 HSD17B12 OXSM OXSM ALOX15 ALOX15 ELOVL3 ELOVL3 ENSMLEP00000038084 ENSMLEP00000038084 ACSF3 ACSF3 HACD2 HACD2 FADS3 FADS3 EDN2 EDN2 FADS1 FADS1 LOC105536648 LOC105536648 TBXAS1 TBXAS1 PRXL2B PRXL2B PTGS2 PTGS2 TMEM196 TMEM196 ACLY ACLY PLP1 PLP1 ENSMLEP00000040851 ENSMLEP00000040851 ENSMLEP00000002173 ENSMLEP00000002173 ENSMLEP00000002280 ENSMLEP00000002280 LPL LPL ALOX12 ALOX12 PRKAA2 PRKAA2 HPGDS HPGDS ENSMLEP00000003988 ENSMLEP00000003988 PLA2G1B PLA2G1B EDN1 EDN1 ACSBG2 ACSBG2 LIPH LIPH PLA2G10 PLA2G10 GSTP1 GSTP1 HACD3 HACD3 MCAT MCAT PRKAB1 PRKAB1 SCD5 SCD5 PTGS1 PTGS1 THNSL1 THNSL1 HACD4 HACD4 LOC105531888 LOC105531888 HSD17B8 HSD17B8 FASN FASN LIPG LIPG ACACA ACACA PRKAG3 PRKAG3 PTGIS PTGIS ENSMLEP00000008459 ENSMLEP00000008459 MECR MECR ENSMLEP00000008990 ENSMLEP00000008990 TECRL TECRL DAGLB DAGLB CBR4 CBR4 ABHD3 ABHD3 PLA2G4F PLA2G4F ACSS1 ACSS1 THNSL2 THNSL2 ACSM1 ACSM1 ELOVL6 ELOVL6 LIPC LIPC DEGS1 DEGS1 PLA2G4A PLA2G4A BRCA1 BRCA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HSDL1Hydroxysteroid dehydrogenase like 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (325 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
FA2HFatty acid 2-hydroxylase; Belongs to the sterol desaturase family. (299 aa)
CYP3A4Cytochrome P450 family 3 subfamily A member 4. (503 aa)
LOC105552915Cytochrome b5 heme-binding domain-containing protein. (482 aa)
ELOVL1Elongation of very long chain fatty acids protein. (286 aa)
HTD2Hydroxyacyl-thioester dehydratase type 2. (162 aa)
TECRTrans-2,3-enoyl-CoA reductase. (315 aa)
QKIKH domain-containing protein. (293 aa)
SUGCTSuccinyl-CoA:glutarate-CoA transferase. (412 aa)
ALOX15BArachidonate 15-lipoxygenase type B. (676 aa)
ENSMLEP00000019669Aldo_ket_red domain-containing protein. (282 aa)
ALOXE3Arachidonate lipoxygenase 3. (711 aa)
PTGDSLipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (182 aa)
ENSMLEP00000020563Uncharacterized protein; Belongs to the fatty acid desaturase type 1 family. (346 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
PECRPeroxisomal trans-2-enoyl-CoA reductase. (247 aa)
CD74CD74 molecule. (294 aa)
ABCD3ATP binding cassette subfamily D member 3. (622 aa)
ALOX12BArachidonate 12-lipoxygenase, 12R type. (701 aa)
ELOVL7Elongation of very long chain fatty acids protein 7; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0 [...] (281 aa)
ACSM4Acyl-CoA synthetase medium chain family member 4. (580 aa)
ENSMLEP00000023414Uncharacterized protein. (307 aa)
LOC105532823Uncharacterized protein. (121 aa)
LIASLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (372 aa)
PCCBPropionyl-CoA carboxylase subunit beta. (569 aa)
ACOT7Acyl-CoA thioesterase 7. (380 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (506 aa)
GSTM2Glutathione S-transferase. (221 aa)
ABHD1Abhydrolase domain containing 1. (391 aa)
CYP2C8Cytochrome P450 family 2 subfamily C member 8; Belongs to the cytochrome P450 family. (487 aa)
ELOVL4Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane [...] (314 aa)
HACD1Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (251 aa)
ASAH2Neutral ceramidase. (780 aa)
SCDUncharacterized protein; Belongs to the fatty acid desaturase type 1 family. (359 aa)
MGLLMonoglyceride lipase. (313 aa)
LTC4SLeukotriene C4 synthase. (150 aa)
LOC105549919Uncharacterized protein. (661 aa)
PTGESProstaglandin E synthase. (152 aa)
XBP1X-box binding protein 1. (204 aa)
ENSMLEP00000030723Aldo_ket_red domain-containing protein. (192 aa)
HNF1AHNF1 homeobox A. (662 aa)
FADS2Fatty acid desaturase 2. (437 aa)
ACSM5Acyl-CoA synthetase medium chain family member 5. (562 aa)
PTGES2GST C-terminal domain-containing protein. (186 aa)
ENSMLEP00000032489Uncharacterized protein. (348 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (326 aa)
ACSM3Acyl-CoA synthetase medium chain family member 3. (586 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
ELOVL5Elongation of very long chain fatty acids protein. (326 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
ABCD1ATP binding cassette subfamily D member 1. (745 aa)
PNPLA8Patatin like phospholipase domain containing 8. (782 aa)
ELOVL2Elongation of very long chain fatty acids protein 2; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production [...] (295 aa)
HSD17B12Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (298 aa)
OXSM3-oxoacyl-ACP synthase, mitochondrial. (377 aa)
ALOX15Arachidonate 15-lipoxygenase. (621 aa)
ELOVL3Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precurs [...] (270 aa)
ENSMLEP00000038084Uncharacterized protein. (218 aa)
ACSF3Acyl-CoA synthetase family member 3. (576 aa)
HACD2Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (158 aa)
FADS3Fatty acid desaturase 3. (441 aa)
EDN2Endothelin 2. (178 aa)
FADS1Fatty acid desaturase 1. (446 aa)
LOC105536648Uncharacterized protein. (509 aa)
TBXAS1Thromboxane A synthase 1; Belongs to the cytochrome P450 family. (562 aa)
PRXL2BPeroxiredoxin like 2B. (141 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
TMEM196Transmembrane protein 196. (179 aa)
ACLYATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1101 aa)
PLP1Proteolipid protein 1. (277 aa)
ENSMLEP00000040851Uncharacterized protein. (287 aa)
ENSMLEP00000002173Thioesterase domain-containing protein. (118 aa)
ENSMLEP00000002280Biotin carboxylation domain-containing protein. (205 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (475 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (618 aa)
PRKAA2Non-specific serine/threonine protein kinase. (542 aa)
HPGDSHematopoietic prostaglandin D synthase; Belongs to the GST superfamily. (199 aa)
ENSMLEP00000003988Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (135 aa)
PLA2G1BPhospholipase A(2). (148 aa)
EDN1Endothelin 1. (211 aa)
ACSBG2Acyl-CoA synthetase bubblegum family member 2. (560 aa)
LIPHLipase H. (455 aa)
PLA2G10Phospholipase A(2). (165 aa)
GSTP1Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
HACD3Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (400 aa)
MCATMalonyl-CoA-acyl carrier protein transacylase. (249 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
SCD5Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (257 aa)
PTGS1Prostaglandin-endoperoxide synthase 1. (632 aa)
THNSL1Threonine synthase like 1. (743 aa)
HACD4Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (232 aa)
LOC105531888Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (156 aa)
HSD17B8Hydroxysteroid 17-beta dehydrogenase 8. (261 aa)
FASNFatty acid synthase. (2510 aa)
LIPGLipase G, endothelial type. (500 aa)
ACACAAcetyl-CoA carboxylase alpha. (2383 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
PTGISProstaglandin I2 synthase; Belongs to the cytochrome P450 family. (423 aa)
ENSMLEP00000008459Uncharacterized protein. (54 aa)
MECRMitochondrial trans-2-enoyl-CoA reductase. (297 aa)
ENSMLEP00000008990Uncharacterized protein. (858 aa)
TECRLTrans-2,3-enoyl-CoA reductase like. (301 aa)
DAGLBDiacylglycerol lipase beta. (678 aa)
CBR4Carbonyl reductase 4. (237 aa)
ABHD3Abhydrolase domain containing 3. (409 aa)
PLA2G4FPhospholipase A2. (849 aa)
ACSS1Acetyl-coenzyme A synthetase. (688 aa)
THNSL2Threonine synthase like 2. (484 aa)
ACSM1Acyl-CoA synthetase medium chain family member 1. (475 aa)
ELOVL6Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] (265 aa)
LIPCLipase C, hepatic type. (500 aa)
DEGS1Delta 4-desaturase, sphingolipid 1. (311 aa)
PLA2G4APhospholipase A2. (749 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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