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| | HSDL1 | Hydroxysteroid dehydrogenase like 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (325 aa) |
| | MIF | Macrophage migration inhibitory factor. (115 aa) |
| | FA2H | Fatty acid 2-hydroxylase; Belongs to the sterol desaturase family. (299 aa) |
| | CYP3A4 | Cytochrome P450 family 3 subfamily A member 4. (503 aa) |
| | LOC105552915 | Cytochrome b5 heme-binding domain-containing protein. (482 aa) |
| | ELOVL1 | Elongation of very long chain fatty acids protein. (286 aa) |
| | HTD2 | Hydroxyacyl-thioester dehydratase type 2. (162 aa) |
| | TECR | Trans-2,3-enoyl-CoA reductase. (315 aa) |
| | QKI | KH domain-containing protein. (293 aa) |
| | SUGCT | Succinyl-CoA:glutarate-CoA transferase. (412 aa) |
| | ALOX15B | Arachidonate 15-lipoxygenase type B. (676 aa) |
| | ENSMLEP00000019669 | Aldo_ket_red domain-containing protein. (282 aa) |
| | ALOXE3 | Arachidonate lipoxygenase 3. (711 aa) |
| | PTGDS | Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (182 aa) |
| | ENSMLEP00000020563 | Uncharacterized protein; Belongs to the fatty acid desaturase type 1 family. (346 aa) |
| | ALOX5 | Arachidonate 5-lipoxygenase. (674 aa) |
| | PECR | Peroxisomal trans-2-enoyl-CoA reductase. (247 aa) |
| | CD74 | CD74 molecule. (294 aa) |
| | ABCD3 | ATP binding cassette subfamily D member 3. (622 aa) |
| | ALOX12B | Arachidonate 12-lipoxygenase, 12R type. (701 aa) |
| | ELOVL7 | Elongation of very long chain fatty acids protein 7; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0 [...] (281 aa) |
| | ACSM4 | Acyl-CoA synthetase medium chain family member 4. (580 aa) |
| | ENSMLEP00000023414 | Uncharacterized protein. (307 aa) |
| | LOC105532823 | Uncharacterized protein. (121 aa) |
| | LIAS | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (372 aa) |
| | PCCB | Propionyl-CoA carboxylase subunit beta. (569 aa) |
| | ACOT7 | Acyl-CoA thioesterase 7. (380 aa) |
| | PRKAG2 | Protein kinase AMP-activated non-catalytic subunit gamma 2. (506 aa) |
| | GSTM2 | Glutathione S-transferase. (221 aa) |
| | ABHD1 | Abhydrolase domain containing 1. (391 aa) |
| | CYP2C8 | Cytochrome P450 family 2 subfamily C member 8; Belongs to the cytochrome P450 family. (487 aa) |
| | ELOVL4 | Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane [...] (314 aa) |
| | HACD1 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (251 aa) |
| | ASAH2 | Neutral ceramidase. (780 aa) |
| | SCD | Uncharacterized protein; Belongs to the fatty acid desaturase type 1 family. (359 aa) |
| | MGLL | Monoglyceride lipase. (313 aa) |
| | LTC4S | Leukotriene C4 synthase. (150 aa) |
| | LOC105549919 | Uncharacterized protein. (661 aa) |
| | PTGES | Prostaglandin E synthase. (152 aa) |
| | XBP1 | X-box binding protein 1. (204 aa) |
| | ENSMLEP00000030723 | Aldo_ket_red domain-containing protein. (192 aa) |
| | HNF1A | HNF1 homeobox A. (662 aa) |
| | FADS2 | Fatty acid desaturase 2. (437 aa) |
| | ACSM5 | Acyl-CoA synthetase medium chain family member 5. (562 aa) |
| | PTGES2 | GST C-terminal domain-containing protein. (186 aa) |
| | ENSMLEP00000032489 | Uncharacterized protein. (348 aa) |
| | PRKAG1 | Protein kinase AMP-activated non-catalytic subunit gamma 1. (326 aa) |
| | ACSM3 | Acyl-CoA synthetase medium chain family member 3. (586 aa) |
| | PRKAB2 | Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa) |
| | ELOVL5 | Elongation of very long chain fatty acids protein. (326 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (559 aa) |
| | ABCD1 | ATP binding cassette subfamily D member 1. (745 aa) |
| | PNPLA8 | Patatin like phospholipase domain containing 8. (782 aa) |
| | ELOVL2 | Elongation of very long chain fatty acids protein 2; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production [...] (295 aa) |
| | HSD17B12 | Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (298 aa) |
| | OXSM | 3-oxoacyl-ACP synthase, mitochondrial. (377 aa) |
| | ALOX15 | Arachidonate 15-lipoxygenase. (621 aa) |
| | ELOVL3 | Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precurs [...] (270 aa) |
| | ENSMLEP00000038084 | Uncharacterized protein. (218 aa) |
| | ACSF3 | Acyl-CoA synthetase family member 3. (576 aa) |
| | HACD2 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (158 aa) |
| | FADS3 | Fatty acid desaturase 3. (441 aa) |
| | EDN2 | Endothelin 2. (178 aa) |
| | FADS1 | Fatty acid desaturase 1. (446 aa) |
| | LOC105536648 | Uncharacterized protein. (509 aa) |
| | TBXAS1 | Thromboxane A synthase 1; Belongs to the cytochrome P450 family. (562 aa) |
| | PRXL2B | Peroxiredoxin like 2B. (141 aa) |
| | PTGS2 | Prostaglandin-endoperoxide synthase 2. (604 aa) |
| | TMEM196 | Transmembrane protein 196. (179 aa) |
| | ACLY | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1101 aa) |
| | PLP1 | Proteolipid protein 1. (277 aa) |
| | ENSMLEP00000040851 | Uncharacterized protein. (287 aa) |
| | ENSMLEP00000002173 | Thioesterase domain-containing protein. (118 aa) |
| | ENSMLEP00000002280 | Biotin carboxylation domain-containing protein. (205 aa) |
| | LPL | Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (475 aa) |
| | ALOX12 | Arachidonate 12-lipoxygenase, 12S type. (618 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (542 aa) |
| | HPGDS | Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. (199 aa) |
| | ENSMLEP00000003988 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (135 aa) |
| | PLA2G1B | Phospholipase A(2). (148 aa) |
| | EDN1 | Endothelin 1. (211 aa) |
| | ACSBG2 | Acyl-CoA synthetase bubblegum family member 2. (560 aa) |
| | LIPH | Lipase H. (455 aa) |
| | PLA2G10 | Phospholipase A(2). (165 aa) |
| | GSTP1 | Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa) |
| | HACD3 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (400 aa) |
| | MCAT | Malonyl-CoA-acyl carrier protein transacylase. (249 aa) |
| | PRKAB1 | Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa) |
| | SCD5 | Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (257 aa) |
| | PTGS1 | Prostaglandin-endoperoxide synthase 1. (632 aa) |
| | THNSL1 | Threonine synthase like 1. (743 aa) |
| | HACD4 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (232 aa) |
| | LOC105531888 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (156 aa) |
| | HSD17B8 | Hydroxysteroid 17-beta dehydrogenase 8. (261 aa) |
| | FASN | Fatty acid synthase. (2510 aa) |
| | LIPG | Lipase G, endothelial type. (500 aa) |
| | ACACA | Acetyl-CoA carboxylase alpha. (2383 aa) |
| | PRKAG3 | Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa) |
| | PTGIS | Prostaglandin I2 synthase; Belongs to the cytochrome P450 family. (423 aa) |
| | ENSMLEP00000008459 | Uncharacterized protein. (54 aa) |
| | MECR | Mitochondrial trans-2-enoyl-CoA reductase. (297 aa) |
| | ENSMLEP00000008990 | Uncharacterized protein. (858 aa) |
| | TECRL | Trans-2,3-enoyl-CoA reductase like. (301 aa) |
| | DAGLB | Diacylglycerol lipase beta. (678 aa) |
| | CBR4 | Carbonyl reductase 4. (237 aa) |
| | ABHD3 | Abhydrolase domain containing 3. (409 aa) |
| | PLA2G4F | Phospholipase A2. (849 aa) |
| | ACSS1 | Acetyl-coenzyme A synthetase. (688 aa) |
| | THNSL2 | Threonine synthase like 2. (484 aa) |
| | ACSM1 | Acyl-CoA synthetase medium chain family member 1. (475 aa) |
| | ELOVL6 | Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] (265 aa) |
| | LIPC | Lipase C, hepatic type. (500 aa) |
| | DEGS1 | Delta 4-desaturase, sphingolipid 1. (311 aa) |
| | PLA2G4A | Phospholipase A2. (749 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa) |
