STRINGSTRING
BDKRB2 BDKRB2 AVPR1B AVPR1B RPTOR RPTOR PAPPA2 PAPPA2 TSC22D3 TSC22D3 MLST8 MLST8 ARHGEF2 ARHGEF2 TLR3 TLR3 SCN2A SCN2A PKD2 PKD2 OXT OXT CLDN1 CLDN1 KCNMA1 KCNMA1 ENSMLEP00000024959 ENSMLEP00000024959 ENSMLEP00000024588 ENSMLEP00000024588 TRPV4 TRPV4 ENSMLEP00000023615 ENSMLEP00000023615 CASP1 CASP1 ATF2 ATF2 LOC105550341 LOC105550341 ENSMLEP00000020896 ENSMLEP00000020896 TH TH KMO KMO YBX3 YBX3 LOC105553473 LOC105553473 STK39 STK39 MAP2K7 MAP2K7 MYLK MYLK LOC105534152 LOC105534152 LRRC8A LRRC8A PTK2B PTK2B RCSD1 RCSD1 EPO EPO PDPK1 PDPK1 SLC2A4 SLC2A4 WNK3 WNK3 LRRC8C LRRC8C FMO1 FMO1 SLC4A11 SLC4A11 NFAT5 NFAT5 OXSR1 OXSR1 MTOR MTOR TSPO TSPO PYCARD PYCARD ITGA2 ITGA2 CAB39 CAB39 SLC2A1 SLC2A1 BAX BAX SLC9A4 SLC9A4 PKN1 PKN1 CAPN3 CAPN3 TSC22D4 TSC22D4 ZFP36L1 ZFP36L1 DDX3X DDX3X TACR3 TACR3 PTGS2 PTGS2 ICOSLG ICOSLG ERRFI1 ERRFI1 SLC12A6 SLC12A6 TP53 TP53 LRRC8E LRRC8E SLC12A5 SLC12A5 RELB RELB AQP1 AQP1 MAP7 MAP7 XRCC5 XRCC5 AQP5 AQP5 AKR1B1 AKR1B1 PLK3 PLK3 NOLC1 NOLC1 MAPK13 MAPK13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (391 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (424 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1291 aa)
PAPPA2Pappalysin 2. (1790 aa)
TSC22D3TSC22 domain family member 3. (200 aa)
MLST8MTOR associated protein, LST8 homolog. (335 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (996 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2005 aa)
PKD2EF-hand domain-containing protein. (386 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1264 aa)
ENSMLEP00000024959Pannexin_like domain-containing protein. (150 aa)
ENSMLEP00000024588Aldo_ket_red domain-containing protein. (279 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
ENSMLEP00000023615Uncharacterized protein. (129 aa)
CASP1Caspase 1; Belongs to the peptidase C14A family. (404 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
LOC105550341Aldo_ket_red domain-containing protein. (306 aa)
ENSMLEP00000020896Uncharacterized protein. (486 aa)
THTyrosine hydroxylase. (549 aa)
KMOKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (469 aa)
YBX3Y-box binding protein 3. (364 aa)
LOC105553473Aldo_ket_red domain-containing protein. (294 aa)
STK39Serine/threonine kinase 39. (475 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (442 aa)
MYLKMyosin light chain kinase. (1912 aa)
LOC105534152Uncharacterized protein; Belongs to the peptidase C14A family. (352 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (810 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
RCSD1RCSD domain containing 1. (468 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (529 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
WNK3WNK lysine deficient protein kinase 3. (1797 aa)
LRRC8CLeucine rich repeat containing 8 VRAC subunit C. (803 aa)
FMO1Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
SLC4A11Solute carrier family 4 member 11. (921 aa)
NFAT5Nuclear factor of activated T cells 5. (1535 aa)
OXSR1Oxidative stress responsive kinase 1. (580 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
TSPOTranslocator protein. (169 aa)
PYCARDPYD and CARD domain containing. (195 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1152 aa)
CAB39Calcium binding protein 39. (341 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa)
BAXBCL2 associated X, apoptosis regulator. (203 aa)
SLC9A4Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (711 aa)
PKN1Protein kinase N1. (829 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (821 aa)
TSC22D4TSC22 domain family member 4. (395 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (733 aa)
TACR3Tachykinin receptor 3; Belongs to the G-protein coupled receptor 1 family. (463 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
ICOSLGUncharacterized protein. (297 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (462 aa)
SLC12A6Solute carrier family 12 member 6. (1150 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
LRRC8ELeucine rich repeat containing 8 VRAC subunit E. (796 aa)
SLC12A5Solute carrier family 12 member 5. (1139 aa)
RELBRELB proto-oncogene, NF-kB subunit. (509 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa)
MAP7Microtubule associated protein 7. (765 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
AQP5Aquaporin 5; Belongs to the MIP/aquaporin (TC 1.A.8) family. (262 aa)
AKR1B1Aldo-keto reductase family 1 member B. (316 aa)
PLK3Serine/threonine-protein kinase PLK. (626 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (711 aa)
MAPK13Mitogen-activated protein kinase. (397 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.