STRINGSTRING
RRAGD RRAGD SESN3 SESN3 RNF152 RNF152 RRAGB RRAGB BHLHA15 BHLHA15 BMPR2 BMPR2 EIF2AK3 EIF2AK3 WNT9B WNT9B PRKAA2 PRKAA2 ATF3 ATF3 ENSMLEP00000003823 ENSMLEP00000003823 SLC2A1 SLC2A1 UPP1 UPP1 SESN1 SESN1 SIRT1 SIRT1 MTOR MTOR ATF4 ATF4 GABARAPL2 GABARAPL2 RRAGA RRAGA BCL2 BCL2 MAPK10 MAPK10 NPRL3 NPRL3 WDR59 WDR59 DAPL1 DAPL1 ATG7 ATG7 PPM1D PPM1D MAP1LC3B MAP1LC3B LOC105533891 LOC105533891 NPRL2 NPRL2 PRKAG3 PRKAG3 JMY JMY GLUL GLUL WNT4 WNT4 CPEB4 CPEB4 GCN1 GCN1 CDKN1A CDKN1A SLC38A3 SLC38A3 TTC5 TTC5 MAP1LC3C MAP1LC3C BMT2 BMT2 ATG14 ATG14 SIK1 SIK1 ENSMLEP00000013771 ENSMLEP00000013771 ENSMLEP00000014188 ENSMLEP00000014188 ENSMLEP00000014595 ENSMLEP00000014595 MYOD1 MYOD1 COMT COMT ENSMLEP00000014760 ENSMLEP00000014760 ENSMLEP00000015404 ENSMLEP00000015404 LRRK2 LRRK2 SFRP1 SFRP1 MAPK8 MAPK8 ENSMLEP00000015684 ENSMLEP00000015684 PICK1 PICK1 BRSK2 BRSK2 FLCN FLCN SLC7A5 SLC7A5 PLIN3 PLIN3 WNT2B WNT2B TBL2 TBL2 WIPI2 WIPI2 IMPACT IMPACT EIF2AK2 EIF2AK2 ENSMLEP00000019669 ENSMLEP00000019669 C12orf66 C12orf66 IFI16 IFI16 ATG5 ATG5 ZC3H12A ZC3H12A ENSMLEP00000021070 ENSMLEP00000021070 MAPK3 MAPK3 PPARA PPARA KLF10 KLF10 KAT5 KAT5 GAS6 GAS6 RRP8 RRP8 RIPOR1 RIPOR1 PLIN2 PLIN2 ENSMLEP00000022361 ENSMLEP00000022361 SLC39A4 SLC39A4 ATF2 ATF2 HSPA5 HSPA5 DNAJC15 DNAJC15 MAPK1 MAPK1 DSC2 DSC2 SESN2 SESN2 FOXA3 FOXA3 MYBBP1A MYBBP1A STK26 STK26 MYH13 MYH13 PDK4 PDK4 SEH1L SEH1L DAP DAP GCGR GCGR PRKAG2 PRKAG2 ITFG2 ITFG2 MIOS MIOS SLC34A1 SLC34A1 EIF2AK4 EIF2AK4 WRN WRN BRSK1 BRSK1 PRKD1 PRKD1 KPTN KPTN ENSMLEP00000029005 ENSMLEP00000029005 MTMR3 MTMR3 NIM1K NIM1K WDR45B WDR45B RNF167 RNF167 KRT20 KRT20 XBP1 XBP1 ENSMLEP00000030723 ENSMLEP00000030723 VPS41 VPS41 SREBF1 SREBF1 CLEC16A CLEC16A RPTOR RPTOR STK24 STK24 FNIP1 FNIP1 WDR24 WDR24 NUAK1 NUAK1 XPR1 XPR1 AMBRA1 AMBRA1 LAMP2 LAMP2 MAP1LC3A MAP1LC3A PRKAG1 PRKAG1 MFSD2A MFSD2A NUAK2 NUAK2 RRAGC RRAGC PRKAA1 PRKAA1 EIF2S1 EIF2S1 TFEB TFEB EHMT2 EHMT2 WIPI1 WIPI1 ENSMLEP00000035740 ENSMLEP00000035740 ALB ALB KIAA1324 KIAA1324 PIK3R4 PIK3R4 MAX MAX CARTPT CARTPT LOC105543400 LOC105543400 PRAF2 PRAF2 PIK3C2B PIK3C2B TP53 TP53 NFE2L2 NFE2L2 CBWD1 CBWD1 GAS2L1 GAS2L1 CHKA CHKA FBXO22 FBXO22 SLC39A5 SLC39A5 SZT2 SZT2 AOC1 AOC1 PCSK9 PCSK9 PCK1 PCK1 ENSMLEP00000040098 ENSMLEP00000040098 SREBF2 SREBF2 MAP3K5 MAP3K5 BECN1 BECN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RRAGDRas related GTP binding D. (400 aa)
SESN3Sestrin 3. (530 aa)
RNF152Ring finger protein 152. (203 aa)
RRAGBRas related GTP binding B. (374 aa)
BHLHA15Basic helix-loop-helix family member a15. (191 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1032 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1012 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
PRKAA2Non-specific serine/threonine protein kinase. (542 aa)
ATF3Activating transcription factor 3. (181 aa)
ENSMLEP00000003823Uncharacterized protein. (201 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa)
UPP1Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (314 aa)
SESN1Sestrin 1. (551 aa)
SIRT1Sirtuin 1. (661 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
ATF4Activating transcription factor 4. (351 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
RRAGARas related GTP binding A. (313 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
MAPK10Mitogen-activated protein kinase. (477 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (546 aa)
WDR59WD repeat domain 59. (974 aa)
DAPL1Uncharacterized protein. (128 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (704 aa)
PPM1DProtein phosphatase, Mg2+/Mn2+ dependent 1D. (605 aa)
MAP1LC3BUncharacterized protein. (121 aa)
LOC105533891Perilipin; Belongs to the perilipin family. (437 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
JMYJunction mediating and regulatory protein, p53 cofactor. (899 aa)
GLULGlutamine synthetase. (373 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
CPEB4Cytoplasmic polyadenylation element binding protein 4. (729 aa)
GCN1GCN1 activator of EIF2AK4. (2665 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
SLC38A3Solute carrier family 38 member 3. (521 aa)
TTC5Tetratricopeptide repeat domain 5. (440 aa)
MAP1LC3CMicrotubule associated protein 1 light chain 3 gamma. (147 aa)
BMT2Base methyltransferase of 25S rRNA 2 homolog. (247 aa)
ATG14Autophagy related 14. (486 aa)
SIK1Uncharacterized protein. (764 aa)
ENSMLEP00000013771PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (104 aa)
ENSMLEP00000014188Uncharacterized protein. (89 aa)
ENSMLEP00000014595Uncharacterized protein. (117 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
COMTCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (221 aa)
ENSMLEP00000014760PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (94 aa)
ENSMLEP00000015404Fork-head domain-containing protein. (531 aa)
LRRK2Leucine rich repeat kinase 2. (2182 aa)
SFRP1Secreted frizzled related protein 1. (206 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ENSMLEP00000015684Uncharacterized protein. (101 aa)
PICK1Protein interacting with PRKCA 1. (398 aa)
BRSK2BR serine/threonine kinase 2. (710 aa)
FLCNFolliculin. (515 aa)
SLC7A5Solute carrier family 7 member 5. (388 aa)
PLIN3Perilipin; Belongs to the perilipin family. (427 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
TBL2Transducin beta like 2. (446 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (258 aa)
IMPACTImpact RWD domain protein. (320 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (551 aa)
ENSMLEP00000019669Aldo_ket_red domain-containing protein. (282 aa)
C12orf66Chromosome 12 open reading frame 66. (470 aa)
IFI16Interferon gamma inducible protein 16. (729 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (601 aa)
ENSMLEP00000021070C2 PI3K-type domain-containing protein; Belongs to the PI3/PI4-kinase family. (201 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
PPARAPeroxisome proliferator activated receptor alpha. (365 aa)
KLF10Kruppel like factor 10. (480 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
GAS6Growth arrest specific 6. (640 aa)
RRP8Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (456 aa)
RIPOR1RHO family interacting cell polarization regulator 1. (1213 aa)
PLIN2Perilipin; Belongs to the perilipin family. (420 aa)
ENSMLEP00000022361Uncharacterized protein; Belongs to the heat shock protein 70 family. (580 aa)
SLC39A4Solute carrier family 39 member 4. (651 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
DNAJC15DnaJ heat shock protein family (Hsp40) member C15. (160 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
DSC2Desmocollin 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (878 aa)
SESN2Sestrin 2. (450 aa)
FOXA3Forkhead box A3. (350 aa)
MYBBP1AMYB binding protein 1a. (1329 aa)
STK26Serine/threonine kinase 26. (438 aa)
MYH13Myosin heavy chain 13; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1894 aa)
PDK4Protein-serine/threonine kinase. (411 aa)
SEH1LSEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (367 aa)
DAPDeath associated protein. (185 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (491 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (506 aa)
ITFG2Integrin alpha FG-GAP repeat containing 2. (447 aa)
MIOSMeiosis regulator for oocyte development. (875 aa)
SLC34A1Solute carrier family 34 member 1. (639 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1644 aa)
WRNWRN RecQ like helicase. (1404 aa)
BRSK1BR serine/threonine kinase 1. (763 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
KPTNKaptin, actin binding protein. (410 aa)
ENSMLEP00000029005ATG7_N domain-containing protein. (78 aa)
MTMR3Myotubularin related protein 3. (1207 aa)
NIM1KNIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. (436 aa)
WDR45BWD repeat domain 45B. (287 aa)
RNF167Ring finger protein 167. (351 aa)
KRT20Keratin 20; Belongs to the intermediate filament family. (424 aa)
XBP1X-box binding protein 1. (204 aa)
ENSMLEP00000030723Aldo_ket_red domain-containing protein. (192 aa)
VPS41Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (880 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1124 aa)
CLEC16AC-type lectin domain containing 16A. (1047 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1291 aa)
STK24Serine/threonine kinase 24. (443 aa)
FNIP1Folliculin interacting protein 1. (1166 aa)
WDR24WD repeat domain 24. (895 aa)
NUAK1NUAK family kinase 1. (656 aa)
XPR1Xenotropic and polytropic retrovirus receptor 1. (696 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1298 aa)
LAMP2Lysosomal associated membrane protein 2. (411 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (106 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (326 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (543 aa)
NUAK2NUAK family kinase 2. (672 aa)
RRAGCRas related GTP binding C. (320 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
TFEBTranscription factor EB. (555 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1266 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (446 aa)
ENSMLEP00000035740Uncharacterized protein. (185 aa)
ALBAlbumin. (604 aa)
KIAA1324KIAA1324. (826 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
MAXMYC associated factor X. (160 aa)
CARTPTCART prepropeptide. (116 aa)
LOC105543400Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family. (335 aa)
PRAF2Uncharacterized protein. (361 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (596 aa)
CBWD1CobW C-terminal domain-containing protein. (395 aa)
GAS2L1Growth arrest specific 2 like 1. (681 aa)
CHKACholine kinase alpha. (410 aa)
FBXO22F-box protein 22. (404 aa)
SLC39A5Solute carrier family 39 member 5. (540 aa)
SZT2SZT2 subunit of KICSTOR complex. (3432 aa)
AOC1Amine oxidase. (755 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9. (692 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
ENSMLEP00000040098Uncharacterized protein. (336 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1138 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1306 aa)
BECN1Beclin 1. (450 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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