(30 nodes) Histone phosphorylation network (Mandrillus leucophaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RPS6KA4	Ribosomal protein S6 kinase. (772 aa)
	ENSMLEP00000040613	Protein kinase domain-containing protein. (286 aa)
	RPS6KA5	Ribosomal protein S6 kinase. (801 aa)
	INCENP	Inner centromere protein. (897 aa)
	CDK1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
	SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (559 aa)
	CCNA2	Cyclin A2; Belongs to the cyclin family. (432 aa)
	AURKB	Aurora kinase B; Belongs to the protein kinase superfamily. (345 aa)
	AURKA	Aurora kinase A; Belongs to the protein kinase superfamily. (384 aa)
	CDK2	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
	NEK11	NIMA related kinase 11. (637 aa)
	PKN1	Protein kinase N1. (829 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (542 aa)
	HIPK4	Homeodomain interacting protein kinase 4. (616 aa)
	VRK1	VRK serine/threonine kinase 1; Belongs to the protein kinase superfamily. (396 aa)
	ENSMLEP00000009377	Zinc_ribbon_2 domain-containing protein. (100 aa)
	AURKC	Aurora kinase C; Belongs to the protein kinase superfamily. (309 aa)
	MST1	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
	DCAF1	DDB1 and CUL4 associated factor 1. (1512 aa)
	JAK2	Tyrosine-protein kinase. (1139 aa)
	VRK2	VRK serine/threonine kinase 2. (507 aa)
	CHEK1	Checkpoint kinase 1. (480 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (302 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (2965 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (426 aa)
	VRK3	VRK serine/threonine kinase 3. (418 aa)
	BAZ1B	Bromodomain adjacent to zinc finger domain 1B. (1611 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	CCNA2	ENSMLEP00000023761	ENSMLEP00000034481	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin A2; Belongs to the cyclin family.	0.697
ATM	CDK1	ENSMLEP00000023761	ENSMLEP00000038503	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.606
ATM	CDK2	ENSMLEP00000023761	ENSMLEP00000001075	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.792
ATM	CHEK1	ENSMLEP00000023761	ENSMLEP00000017433	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Checkpoint kinase 1.	0.951
ATM	ENSMLEP00000040613	ENSMLEP00000023761	ENSMLEP00000040613	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein kinase domain-containing protein.	0.606
ATM	HIPK4	ENSMLEP00000023761	ENSMLEP00000003728	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Homeodomain interacting protein kinase 4.	0.503
ATM	PRKAA1	ENSMLEP00000023761	ENSMLEP00000034493	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Non-specific serine/threonine protein kinase.	0.507
AURKA	AURKB	ENSMLEP00000000969	ENSMLEP00000030453	Aurora kinase A; Belongs to the protein kinase superfamily.	Aurora kinase B; Belongs to the protein kinase superfamily.	0.746
AURKA	AURKC	ENSMLEP00000000969	ENSMLEP00000010196	Aurora kinase A; Belongs to the protein kinase superfamily.	Aurora kinase C; Belongs to the protein kinase superfamily.	0.741
AURKA	CCNA2	ENSMLEP00000000969	ENSMLEP00000034481	Aurora kinase A; Belongs to the protein kinase superfamily.	Cyclin A2; Belongs to the cyclin family.	0.885
AURKA	CDK1	ENSMLEP00000000969	ENSMLEP00000038503	Aurora kinase A; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.886
AURKA	CDK2	ENSMLEP00000000969	ENSMLEP00000001075	Aurora kinase A; Belongs to the protein kinase superfamily.	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.716
AURKA	ENSMLEP00000040613	ENSMLEP00000000969	ENSMLEP00000040613	Aurora kinase A; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.886
AURKA	INCENP	ENSMLEP00000000969	ENSMLEP00000039609	Aurora kinase A; Belongs to the protein kinase superfamily.	Inner centromere protein.	0.978
AURKB	AURKA	ENSMLEP00000030453	ENSMLEP00000000969	Aurora kinase B; Belongs to the protein kinase superfamily.	Aurora kinase A; Belongs to the protein kinase superfamily.	0.746
AURKB	AURKC	ENSMLEP00000030453	ENSMLEP00000010196	Aurora kinase B; Belongs to the protein kinase superfamily.	Aurora kinase C; Belongs to the protein kinase superfamily.	0.611
AURKB	CCNA2	ENSMLEP00000030453	ENSMLEP00000034481	Aurora kinase B; Belongs to the protein kinase superfamily.	Cyclin A2; Belongs to the cyclin family.	0.911
AURKB	CDK1	ENSMLEP00000030453	ENSMLEP00000038503	Aurora kinase B; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.927
AURKB	CDK2	ENSMLEP00000030453	ENSMLEP00000001075	Aurora kinase B; Belongs to the protein kinase superfamily.	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.674
AURKB	ENSMLEP00000040613	ENSMLEP00000030453	ENSMLEP00000040613	Aurora kinase B; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.926