STRINGSTRING
SMTNL1 SMTNL1 PDGFB PDGFB DMPK DMPK DYRK1A DYRK1A AURKB AURKB RPS6KB1 RPS6KB1 MYO3A MYO3A PAK2 PAK2 MORC3 MORC3 CSNK2A2 CSNK2A2 MAPK10 MAPK10 VRK1 VRK1 RIPK1 RIPK1 CAMKV CAMKV STK38L STK38L BCL2 BCL2 MAPKAPK2 MAPKAPK2 IL24 IL24 MTOR MTOR TAF1L TAF1L DGKQ DGKQ ENSMLEP00000004525 ENSMLEP00000004525 PKD1 PKD1 RPS6KA2 RPS6KA2 CAB39 CAB39 HIPK4 HIPK4 PRKAA2 PRKAA2 ENSMLEP00000003444 ENSMLEP00000003444 RPS6KA6 RPS6KA6 PKN1 PKN1 TSSK6 TSSK6 EIF2AK3 EIF2AK3 NTRK2 NTRK2 CDK5R1 CDK5R1 DYRK4 DYRK4 CDK2 CDK2 AURKA AURKA CAMK1D CAMK1D LOC105538921 LOC105538921 CAMK2D CAMK2D PLK2 PLK2 PKN2 PKN2 MAPKAPK3 MAPKAPK3 MARK3 MARK3 UHMK1 UHMK1 MAPKAPK5 MAPKAPK5 PINK1 PINK1 PRKD1 PRKD1 BRSK1 BRSK1 VRK3 VRK3 LOC105537149 LOC105537149 RICTOR RICTOR GSK3B GSK3B PRKCB PRKCB SMG1 SMG1 SRPK2 SRPK2 DYRK2 DYRK2 CDC7 CDC7 ATM ATM MAPK1 MAPK1 CHUK CHUK TBK1 TBK1 AKT1 AKT1 MAST3 MAST3 TLK1 TLK1 CSNK2A1 CSNK2A1 MAPK12 MAPK12 STK32C STK32C PNCK PNCK MAPK9 MAPK9 CLSPN CLSPN MAPK7 MAPK7 NLK NLK MAP3K12 MAP3K12 RPS6KB2 RPS6KB2 ENSMLEP00000009377 ENSMLEP00000009377 MAST2 MAST2 ROCK2 ROCK2 PRKX PRKX CHEK2 CHEK2 AURKC AURKC ULK3 ULK3 PIKFYVE PIKFYVE NEK7 NEK7 TNKS TNKS CLK1 CLK1 MAP3K13 MAP3K13 PDPK1 PDPK1 MST1 MST1 ENSMLEP00000012041 ENSMLEP00000012041 EPO EPO DYRK1B DYRK1B RPS6KA4 RPS6KA4 ATR ATR PRKG2 PRKG2 MAP4K1 MAP4K1 MARK1 MARK1 CSNK1G1 CSNK1G1 PBK PBK IKBKE IKBKE MAST4 MAST4 PRKCQ PRKCQ LRRK2 LRRK2 HIPK3 HIPK3 ENSMLEP00000015528 ENSMLEP00000015528 PRKCE PRKCE MAPK8 MAPK8 ENSMLEP00000015812 ENSMLEP00000015812 VRK2 VRK2 CSNK1A1 CSNK1A1 BRSK2 BRSK2 PRKCZ PRKCZ LOC105555268 LOC105555268 IKBKB IKBKB DCLK2 DCLK2 LMTK2 LMTK2 BAK1 BAK1 STK39 STK39 ERN1 ERN1 DCLK3 DCLK3 PRKDC PRKDC CDK5 CDK5 PKN3 PKN3 ENSMLEP00000019571 ENSMLEP00000019571 RPS6KA3 RPS6KA3 LOC105554912 LOC105554912 MKNK2 MKNK2 MYO3B MYO3B PRKCA PRKCA GRK2 GRK2 NEK6 NEK6 TAF1 TAF1 TGFBR1 TGFBR1 GAS6 GAS6 AKT2 AKT2 CAMK4 CAMK4 MAP3K20 MAP3K20 PLK1 PLK1 ENSMLEP00000040613 ENSMLEP00000040613 PDK3 PDK3 RPS6KA5 RPS6KA5 TLK2 TLK2 HIPK2 HIPK2 TTBK2 TTBK2 PCK1 PCK1 ENSMLEP00000038778 ENSMLEP00000038778 CDK1 CDK1 MAPK14 MAPK14 MKNK1 MKNK1 RPS6KA1 RPS6KA1 TDGF1 TDGF1 ENSMLEP00000038006 ENSMLEP00000038006 ULK1 ULK1 DCLK1 DCLK1 MARK2 MARK2 ROCK1 ROCK1 AKT3 AKT3 WNK1 WNK1 CAMK1G CAMK1G TOP1 TOP1 LATS2 LATS2 TGFBR2 TGFBR2 IL20 IL20 TTBK1 TTBK1 SLC1A1 SLC1A1 SRC SRC TSSK4 TSSK4 MASTL MASTL CAMK1 CAMK1 ULK2 ULK2 PRKAA1 PRKAA1 CSNK1A1L CSNK1A1L PRKD2 PRKD2 LATS1 LATS1 PRKCD PRKCD HIPK1 HIPK1 MAPK13 MAPK13 SYK SYK STK32B STK32B PRKCI PRKCI SGK2 SGK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMTNL1Smoothelin like 1. (496 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
DMPKDM1 protein kinase. (630 aa)
DYRK1ADual specificity tyrosine phosphorylation regulated kinase 1A. (754 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (345 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
MYO3AMyosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1620 aa)
PAK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (477 aa)
MORC3MORC family CW-type zinc finger 3. (940 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (323 aa)
MAPK10Mitogen-activated protein kinase. (477 aa)
VRK1VRK serine/threonine kinase 1; Belongs to the protein kinase superfamily. (396 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (620 aa)
CAMKVCaM kinase like vesicle associated. (501 aa)
STK38LNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (464 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
MAPKAPK2MAPK activated protein kinase 2. (362 aa)
IL24Interleukin 24. (206 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
TAF1LTranscription initiation factor TFIID subunit. (1884 aa)
DGKQDiacylglycerol kinase. (778 aa)
ENSMLEP00000004525Protein kinase domain-containing protein. (144 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4124 aa)
RPS6KA2Ribosomal protein S6 kinase. (728 aa)
CAB39Calcium binding protein 39. (341 aa)
HIPK4Homeodomain interacting protein kinase 4. (616 aa)
PRKAA2Non-specific serine/threonine protein kinase. (542 aa)
ENSMLEP00000003444Protein kinase domain-containing protein. (539 aa)
RPS6KA6Ribosomal protein S6 kinase. (744 aa)
PKN1Protein kinase N1. (829 aa)
TSSK6Testis specific serine kinase 6; Belongs to the protein kinase superfamily. (273 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1012 aa)
NTRK2Tyrosine-protein kinase receptor. (724 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
DYRK4Dual specificity tyrosine phosphorylation regulated kinase 4. (520 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (384 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID. (354 aa)
LOC105538921Serine/threonine kinase 32A. (263 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (441 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
PKN2Protein kinase N2. (983 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa)
MARK3Non-specific serine/threonine protein kinase. (764 aa)
UHMK1U2AF homology motif kinase 1. (419 aa)
MAPKAPK5MAPK activated protein kinase 5. (471 aa)
PINK1PTEN induced kinase 1. (545 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
BRSK1BR serine/threonine kinase 1. (763 aa)
VRK3VRK serine/threonine kinase 3. (418 aa)
LOC105537149Protein kinase domain-containing protein. (711 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1699 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (582 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3635 aa)
SRPK2SRSF protein kinase 2. (687 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (604 aa)
CDC7Protein kinase domain-containing protein. (574 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (2965 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
TBK1TANK binding kinase 1. (729 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
MAST3Microtubule associated serine/threonine kinase 3. (1247 aa)
TLK1Protein kinase domain-containing protein. (750 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
MAPK12Mitogen-activated protein kinase. (292 aa)
STK32CSerine/threonine kinase 32C; Belongs to the protein kinase superfamily. (397 aa)
PNCKPregnancy up-regulated nonubiquitous CaM kinase; Belongs to the protein kinase superfamily. (422 aa)
MAPK9Mitogen-activated protein kinase. (395 aa)
CLSPNClaspin. (1072 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (890 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
ENSMLEP00000009377Zinc_ribbon_2 domain-containing protein. (100 aa)
MAST2Microtubule associated serine/threonine kinase 2. (1639 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1375 aa)
PRKXProtein kinase X-linked. (304 aa)
CHEK2Checkpoint kinase 2. (558 aa)
AURKCAurora kinase C; Belongs to the protein kinase superfamily. (309 aa)
ULK3Unc-51 like kinase 3. (482 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2070 aa)
NEK7NIMA related kinase 7; Belongs to the protein kinase superfamily. (302 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
CLK1CDC like kinase 1. (526 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (529 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
ENSMLEP00000012041C2 domain-containing protein. (121 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
DYRK1BDual specificity tyrosine phosphorylation regulated kinase 1B. (629 aa)
RPS6KA4Ribosomal protein S6 kinase. (772 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
MAP4K1Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (843 aa)
MARK1Non-specific serine/threonine protein kinase. (796 aa)
CSNK1G1Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (475 aa)
PBKPDZ binding kinase. (334 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (697 aa)
MAST4Microtubule associated serine/threonine kinase family member 4. (2502 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
LRRK2Leucine rich repeat kinase 2. (2182 aa)
HIPK3Homeodomain interacting protein kinase 3. (1215 aa)
ENSMLEP00000015528Uncharacterized protein. (184 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ENSMLEP00000015812Uncharacterized protein. (66 aa)
VRK2VRK serine/threonine kinase 2. (507 aa)
CSNK1A1Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily. (358 aa)
BRSK2BR serine/threonine kinase 2. (710 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
LOC105555268Protein kinase domain-containing protein. (542 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (706 aa)
DCLK2Doublecortin like kinase 2. (755 aa)
LMTK2Lemur tyrosine kinase 2. (1467 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
STK39Serine/threonine kinase 39. (475 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (959 aa)
DCLK3Doublecortin like kinase 3. (817 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit. (3556 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (302 aa)
PKN3Protein kinase N3. (865 aa)
ENSMLEP00000019571Protein kinase domain-containing protein. (324 aa)
RPS6KA3Ribosomal protein S6 kinase. (742 aa)
LOC105554912Protein kinase domain-containing protein. (171 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (383 aa)
MYO3BMyosin IIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1341 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (701 aa)
NEK6NIMA related kinase 6; Belongs to the protein kinase superfamily. (353 aa)
TAF1Transcription initiation factor TFIID subunit. (1881 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
GAS6Growth arrest specific 6. (640 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (800 aa)
PLK1Serine/threonine-protein kinase PLK. (603 aa)
ENSMLEP00000040613Protein kinase domain-containing protein. (286 aa)
PDK3Protein-serine/threonine kinase. (415 aa)
RPS6KA5Ribosomal protein S6 kinase. (801 aa)
TLK2Tousled like kinase 2. (714 aa)
HIPK2Homeodomain interacting protein kinase 2. (1196 aa)
TTBK2Tau tubulin kinase 2; Belongs to the intermediate filament family. (1642 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
ENSMLEP00000038778Uncharacterized protein. (300 aa)
CDK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
MKNK1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (465 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (171 aa)
ENSMLEP00000038006Uncharacterized protein; Belongs to the protein kinase superfamily. (275 aa)
ULK1Unc-51 like autophagy activating kinase 1. (996 aa)
DCLK1Doublecortin like kinase 1. (740 aa)
MARK2Non-specific serine/threonine protein kinase. (763 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
WNK1WNK lysine deficient protein kinase 1. (2668 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (476 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (751 aa)
LATS2Non-specific serine/threonine protein kinase. (810 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (560 aa)
IL20Interleukin 20. (176 aa)
TTBK1Tau tubulin kinase 1. (1324 aa)
SLC1A1Solute carrier family 1 member 1. (524 aa)
SRCTyrosine-protein kinase. (542 aa)
TSSK4Testis specific serine kinase 4. (338 aa)
MASTLMicrotubule associated serine/threonine kinase like. (772 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1006 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
CSNK1A1LCasein kinase 1 alpha 1 like. (243 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (888 aa)
LATS1Large tumor suppressor kinase 1. (1019 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
HIPK1Homeodomain interacting protein kinase 1. (1210 aa)
MAPK13Mitogen-activated protein kinase. (397 aa)
SYKTyrosine-protein kinase. (618 aa)
STK32BSerine/threonine kinase 32B. (296 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (583 aa)
SGK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (367 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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