(71 nodes) Clathrin binding network (Mandrillus leucophaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SCLT1	Sodium channel and clathrin linker 1. (663 aa)
	AP1M2	AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (386 aa)
	SYT4	Synaptotagmin 4. (425 aa)
	SMAP1	Small ArfGAP 1. (451 aa)
	LRRK2	Leucine rich repeat kinase 2. (2182 aa)
	TEPSIN	TEPSIN adaptor related protein complex 4 accessory protein. (550 aa)
	EPN1	Epsin 1. (662 aa)
	AP1B1	AP complex subunit beta. (949 aa)
	CEMIP	Cell migration inducing hyaluronidase 1. (1361 aa)
	CLINT1	Clathrin interactor 1. (643 aa)
	SYT12	Synaptotagmin 12. (421 aa)
	LMBRD1	LMBR1 domain containing 1. (540 aa)
	SYT2	Synaptotagmin 2. (419 aa)
	SYT13	Synaptotagmin 13. (365 aa)
	SYT9	Synaptotagmin 9. (491 aa)
	TOM1L2	Target of myb1 like 2 membrane trafficking protein; Belongs to the TOM1 family. (507 aa)
	BIN1	Bridging integrator 1. (593 aa)
	AP2A2	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (939 aa)
	TRPC5	Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (974 aa)
	LDLR	Low density lipoprotein receptor. (860 aa)
	DNAJC6	DnaJ heat shock protein family (Hsp40) member C6. (942 aa)
	SNAP91	Synaptosome associated protein 91. (872 aa)
	AP1G2	AP-1 complex subunit gamma. (785 aa)
	PIK3C2A	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1686 aa)
	AP1G1	AP-1 complex subunit gamma. (825 aa)
	TOM1L1	Target of myb1 like 1 membrane trafficking protein; Belongs to the TOM1 family. (436 aa)
	LRP1	LDL receptor related protein 1. (4546 aa)
	NSG1	Neuronal vesicle trafficking associated 1. (185 aa)
	STON2	Stonin-2; Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating; Belongs to the Stoned B family. (920 aa)
	NSG2	Neuronal vesicle trafficking associated 2. (171 aa)
	SYT15	Uncharacterized protein. (333 aa)
	EPN2	Epsin 2. (643 aa)
	GPR107	G protein-coupled receptor 107. (552 aa)
	CLTB	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (203 aa)
	EPN3	Epsin 3. (632 aa)
	AP2B1	AP complex subunit beta. (942 aa)
	CALY	Calcyon neuron specific vesicular protein. (220 aa)
	HIP1R	Huntingtin interacting protein 1 related. (1063 aa)
	CLBA1	Clathrin binding box of aftiphilin containing 1. (325 aa)
	DAB2	DAB adaptor protein 2. (770 aa)
	GAK	Cyclin G associated kinase. (1311 aa)
	HIP1	Huntingtin interacting protein 1. (987 aa)
	ENSMLEP00000040747	Uncharacterized protein. (523 aa)
	AFTPH	Aftiphilin. (935 aa)
	CLTC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1679 aa)
	PICALM	Phosphatidylinositol binding clathrin assembly protein. (674 aa)
	ENTHD1	ENTH domain containing 1. (608 aa)
	AP1M1	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (435 aa)
	AP2A1	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (912 aa)
	ENSMLEP00000025432	B2-adapt-app_C domain-containing protein. (224 aa)
	AP1S3	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (164 aa)
	SYT3	Synaptotagmin 3. (575 aa)
	GPR108	Uncharacterized protein. (438 aa)
	CLTA	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
	CLHC1	Clathrin heavy chain linker domain-containing protein 1. (526 aa)
	SYT11	Synaptotagmin 11. (431 aa)
	AP2S1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
	SYT7	Synaptotagmin 7. (684 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1. (308 aa)
	SYT6	Synaptotagmin 6. (455 aa)
	CLTCL1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1572 aa)
	STON1	Stonin-1; May be involved in the endocytic machinery. (735 aa)
	SYT8	Synaptotagmin 8. (387 aa)
	AP1S2	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
	SYT17	Synaptotagmin 17. (470 aa)
	AP1S1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
	TOM1	Target of myb1 membrane trafficking protein; Belongs to the TOM1 family. (489 aa)
	SYT5	Synaptotagmin 5. (386 aa)
	AP4B1	AP complex subunit beta; Belongs to the adaptor complexes large subunit family. (739 aa)
	ARMC9	Armadillo repeat containing 9. (818 aa)
	DNER	Delta/notch like EGF repeat containing. (650 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFTPH	AP1B1	ENSMLEP00000012275	ENSMLEP00000007452	Aftiphilin.	AP complex subunit beta.	0.420
AFTPH	AP1G1	ENSMLEP00000012275	ENSMLEP00000032227	Aftiphilin.	AP-1 complex subunit gamma.	0.468
AFTPH	AP1G2	ENSMLEP00000012275	ENSMLEP00000030600	Aftiphilin.	AP-1 complex subunit gamma.	0.510
AFTPH	AP1M1	ENSMLEP00000012275	ENSMLEP00000027232	Aftiphilin.	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	0.587
AFTPH	AP1M2	ENSMLEP00000012275	ENSMLEP00000005067	Aftiphilin.	AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	0.741
AFTPH	AP1S1	ENSMLEP00000012275	ENSMLEP00000002724	Aftiphilin.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.549
AFTPH	AP1S2	ENSMLEP00000012275	ENSMLEP00000002437	Aftiphilin.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.757
AFTPH	AP1S3	ENSMLEP00000012275	ENSMLEP00000025355	Aftiphilin.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.613
AFTPH	AP2S1	ENSMLEP00000012275	ENSMLEP00000020033	Aftiphilin.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.403
AFTPH	CLTC	ENSMLEP00000012275	ENSMLEP00000013187	Aftiphilin.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.423
AFTPH	CLTCL1	ENSMLEP00000012275	ENSMLEP00000017151	Aftiphilin.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.414
AP1B1	AFTPH	ENSMLEP00000007452	ENSMLEP00000012275	AP complex subunit beta.	Aftiphilin.	0.420
AP1B1	AP1G1	ENSMLEP00000007452	ENSMLEP00000032227	AP complex subunit beta.	AP-1 complex subunit gamma.	0.998
AP1B1	AP1G2	ENSMLEP00000007452	ENSMLEP00000030600	AP complex subunit beta.	AP-1 complex subunit gamma.	0.993
AP1B1	AP1M1	ENSMLEP00000007452	ENSMLEP00000027232	AP complex subunit beta.	AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	0.999
AP1B1	AP1M2	ENSMLEP00000007452	ENSMLEP00000005067	AP complex subunit beta.	AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.	0.990
AP1B1	AP1S1	ENSMLEP00000007452	ENSMLEP00000002724	AP complex subunit beta.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.995
AP1B1	AP1S2	ENSMLEP00000007452	ENSMLEP00000002437	AP complex subunit beta.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.989
AP1B1	AP1S3	ENSMLEP00000007452	ENSMLEP00000025355	AP complex subunit beta.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.998
AP1B1	AP2A1	ENSMLEP00000007452	ENSMLEP00000000201	AP complex subunit beta.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.953