(78 nodes) Negative regulation of transforming growth factor beta receptor signaling pathway network (Mandrillus leucophaeus)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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protein homology

Your Input:
	GLG1	Golgi glycoprotein 1. (1207 aa)
	ING2	Inhibitor of growth protein. (280 aa)
	ENSMLEP00000000917	Uncharacterized protein. (126 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (287 aa)
	BMP2	Bone morphogenetic protein 2. (396 aa)
	VEPH1-2	Uncharacterized protein. (196 aa)
	SPRED1	Sprouty related EVH1 domain containing 1. (444 aa)
	SMURF2	SMAD specific E3 ubiquitin protein ligase 2. (624 aa)
	BRMS1	BRMS1 transcriptional repressor and anoikis regulator. (246 aa)
	ZNF451	Zinc finger protein 451. (1061 aa)
	CD109	CD109 molecule. (1383 aa)
	SPRY1	Sprouty RTK signaling antagonist 1. (319 aa)
	SIRT1	Sirtuin 1. (661 aa)
	ING1	Inhibitor of growth protein. (419 aa)
	ENG	Endoglin. (598 aa)
	HTRA1	HtrA serine peptidase 1. (402 aa)
	ADAMTSL2	ADAMTS like 2. (1053 aa)
	TET1	Tet methylcytosine dioxygenase 1. (2132 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (529 aa)
	SAP130	Sin3A associated protein 130. (1020 aa)
	PPM1A	Protein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)
	BAMBI	BMP and activin membrane bound inhibitor. (345 aa)
	FBN2	Fibrillin 2. (2912 aa)
	LDLRAD4	Low density lipoprotein receptor class A domain containing 4. (306 aa)
	MTMR4	Myotubularin related protein 4. (1199 aa)
	WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (576 aa)
	SPINT3	Serine peptidase inhibitor, Kunitz type 3. (89 aa)
	ASPN	Asporin. (374 aa)
	NRROS	Negative regulator of reactive oxygen species. (692 aa)
	DNM2	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (810 aa)
	CHST11	Carbohydrate sulfotransferase. (312 aa)
	HTRA4	HtrA serine peptidase 4. (407 aa)
	ENSMLEP00000016075	PPM-type phosphatase domain-containing protein. (351 aa)
	VEPH1	Ventricular zone expressed PH domain containing 1. (687 aa)
	SAP30L	SAP30 like. (158 aa)
	SAP30	Sin3A associated protein 30. (220 aa)
	FBN1	Fibrillin 1. (2883 aa)
	ARID4B	AT-rich interaction domain 4B. (1307 aa)
	PRDM16	PR/SET domain 16. (1148 aa)
	ONECUT2	One cut domain family member. (464 aa)
	IL17RD	Interleukin 17 receptor D. (631 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (365 aa)
	SLC2A10	Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (544 aa)
	SNX25	Sorting nexin 25. (840 aa)
	ENSMLEP00000022361	Uncharacterized protein; Belongs to the heat shock protein 70 family. (580 aa)
	HSPA5	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
	SKI	SKI proto-oncogene. (655 aa)
	PBLD	Phenazine biosynthesis like protein domain containing. (270 aa)
	SKIL	SKI like proto-oncogene. (684 aa)
	STUB1	STIP1 homology and U-box containing protein 1. (250 aa)
	PMEPA1	Prostate transmembrane protein, androgen induced 1. (259 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (163 aa)
	SPRED2	Sprouty related EVH1 domain containing 2. (415 aa)
	BRMS1L	BRMS1 like transcriptional repressor. (323 aa)
	SMAD7	MH2 domain-containing protein. (211 aa)
	DAND5	DAN domain BMP antagonist family member 5. (189 aa)
	XBP1	X-box binding protein 1. (204 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (338 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	LEMD3	LEM domain containing 3. (911 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	ENSMLEP00000033592	c-SKI_SMAD_bind domain-containing protein. (298 aa)
	SMURF1	E3 ubiquitin-protein ligase. (748 aa)
	CIDEA	Cell death inducing DFFA like effector a. (222 aa)
	SPRED3	Sprouty related EVH1 domain containing 3. (232 aa)
	ADAM17	ADAM metallopeptidase domain 17. (824 aa)
	BCL9L	BCL9 like. (1500 aa)
	HTRA3	HtrA serine peptidase 3. (409 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
	STRAP	Serine/threonine kinase receptor associated protein. (363 aa)
	TGFBR3	Transforming growth factor beta receptor 3. (851 aa)
	SIN3A	SIN3 transcription regulator family member A. (1273 aa)
	EMILIN1	Elastin microfibril interfacer 1. (1016 aa)
	TGFB1I1	Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (461 aa)
	ZBTB7A	Zinc finger and BTB domain containing 7A. (347 aa)
	WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (461 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTSL2	FBN1	ENSMLEP00000009393	ENSMLEP00000017727	ADAMTS like 2.	Fibrillin 1.	0.443
ARID4B	BRMS1	ENSMLEP00000018970	ENSMLEP00000003933	AT-rich interaction domain 4B.	BRMS1 transcriptional repressor and anoikis regulator.	0.986
ARID4B	BRMS1L	ENSMLEP00000018970	ENSMLEP00000029263	AT-rich interaction domain 4B.	BRMS1 like transcriptional repressor.	0.988
ARID4B	HDAC2	ENSMLEP00000018970	ENSMLEP00000032989	AT-rich interaction domain 4B.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.954
ARID4B	ING1	ENSMLEP00000018970	ENSMLEP00000005653	AT-rich interaction domain 4B.	Inhibitor of growth protein.	0.812
ARID4B	ING2	ENSMLEP00000018970	ENSMLEP00000000859	AT-rich interaction domain 4B.	Inhibitor of growth protein.	0.741
ARID4B	SAP130	ENSMLEP00000018970	ENSMLEP00000011934	AT-rich interaction domain 4B.	Sin3A associated protein 130.	0.871
ARID4B	SAP30	ENSMLEP00000018970	ENSMLEP00000017585	AT-rich interaction domain 4B.	Sin3A associated protein 30.	0.990
ARID4B	SAP30L	ENSMLEP00000018970	ENSMLEP00000017451	AT-rich interaction domain 4B.	SAP30 like.	0.985
ARID4B	SIN3A	ENSMLEP00000018970	ENSMLEP00000037944	AT-rich interaction domain 4B.	SIN3 transcription regulator family member A.	0.947
ARID4B	TET1	ENSMLEP00000018970	ENSMLEP00000009847	AT-rich interaction domain 4B.	Tet methylcytosine dioxygenase 1.	0.483
BAMBI	SMAD7	ENSMLEP00000012217	ENSMLEP00000029308	BMP and activin membrane bound inhibitor.	MH2 domain-containing protein.	0.919
BMP2	ENG	ENSMLEP00000001642	ENSMLEP00000008075	Bone morphogenetic protein 2.	Endoglin.	0.406
BMP2	SMAD7	ENSMLEP00000001642	ENSMLEP00000029308	Bone morphogenetic protein 2.	MH2 domain-containing protein.	0.674
BMP2	SMURF1	ENSMLEP00000001642	ENSMLEP00000034436	Bone morphogenetic protein 2.	E3 ubiquitin-protein ligase.	0.536
BMP2	SMURF2	ENSMLEP00000001642	ENSMLEP00000003476	Bone morphogenetic protein 2.	SMAD specific E3 ubiquitin protein ligase 2.	0.536
BRMS1	ARID4B	ENSMLEP00000003933	ENSMLEP00000018970	BRMS1 transcriptional repressor and anoikis regulator.	AT-rich interaction domain 4B.	0.986
BRMS1	HDAC2	ENSMLEP00000003933	ENSMLEP00000032989	BRMS1 transcriptional repressor and anoikis regulator.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.651
BRMS1	ING1	ENSMLEP00000003933	ENSMLEP00000005653	BRMS1 transcriptional repressor and anoikis regulator.	Inhibitor of growth protein.	0.546
BRMS1	ING2	ENSMLEP00000003933	ENSMLEP00000000859	BRMS1 transcriptional repressor and anoikis regulator.	Inhibitor of growth protein.	0.734