(40 nodes) Negative regulation of epithelial cell differentiation network (Mandrillus leucophaeus)

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (595 aa)
	TBX3	T-box transcription factor 3. (743 aa)
	GRHL2	Grainyhead like transcription factor 2. (614 aa)
	SPRED1	Sprouty related EVH1 domain containing 1. (444 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (785 aa)
	SPRY1	Sprouty RTK signaling antagonist 1. (319 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	S1PR3	Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (378 aa)
	NOTCH4	Notch receptor 4. (2000 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
	FST	Follistatin. (317 aa)
	NKX6-3	Homeobox domain-containing protein. (265 aa)
	SRSF6	Serine and arginine rich splicing factor 6. (214 aa)
	NODAL	Nodal growth differentiation factor. (303 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (606 aa)
	NOTCH4-2	Notch receptor 4. (159 aa)
	REG3G	Regenerating family member 3 gamma. (174 aa)
	NOTCH1	Notch receptor 1. (2076 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1214 aa)
	OSR1	Odd-skipped related transcription factor 1. (266 aa)
	FRZB	Frizzled related protein. (325 aa)
	REG3A	Regenerating family member 3 alpha. (175 aa)
	OVOL2	Ovo like zinc finger 2. (258 aa)
	FOXJ2	Forkhead box J2. (555 aa)
	XDH	Xanthine dehydrogenase. (1333 aa)
	SPRED2	Sprouty related EVH1 domain containing 2. (415 aa)
	STAT1	Signal transducer and activator of transcription. (758 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (338 aa)
	ENSMLEP00000033047	Uncharacterized protein. (67 aa)
	ACVRL1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
	ZEB1	Zinc finger E-box binding homeobox 1. (1127 aa)
	YAP1	Yes associated protein 1. (497 aa)
	MMP9	Matrix metallopeptidase 9. (707 aa)
	SPRED3	Sprouty related EVH1 domain containing 3. (232 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
	ID1	Inhibitor of DNA binding 1, HLH protein. (154 aa)
	SIX2	SIX homeobox 2. (290 aa)
	GDF3	Growth differentiation factor 3. (364 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVRL1	GDF3	ENSMLEP00000033245	ENSMLEP00000040631	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Growth differentiation factor 3.	0.481
ACVRL1	NODAL	ENSMLEP00000033245	ENSMLEP00000014977	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Nodal growth differentiation factor.	0.479
CAV1	CTNNB1	ENSMLEP00000009962	ENSMLEP00000009207	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Catenin beta 1.	0.624
CAV1	FGF10	ENSMLEP00000009962	ENSMLEP00000009747	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.477
CAV1	SPRED1	ENSMLEP00000009962	ENSMLEP00000002712	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Sprouty related EVH1 domain containing 1.	0.483
CTNNB1	CAV1	ENSMLEP00000009207	ENSMLEP00000009962	Catenin beta 1.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.624
CTNNB1	ENSMLEP00000033047	ENSMLEP00000009207	ENSMLEP00000033047	Catenin beta 1.	Uncharacterized protein.	0.556
CTNNB1	EZH2	ENSMLEP00000009207	ENSMLEP00000035774	Catenin beta 1.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.619
CTNNB1	FRZB	ENSMLEP00000009207	ENSMLEP00000024692	Catenin beta 1.	Frizzled related protein.	0.434
CTNNB1	JAG1	ENSMLEP00000009207	ENSMLEP00000021823	Catenin beta 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.405
CTNNB1	KRAS	ENSMLEP00000009207	ENSMLEP00000008436	Catenin beta 1.	KRAS proto-oncogene, GTPase.	0.524
CTNNB1	MMP9	ENSMLEP00000009207	ENSMLEP00000035348	Catenin beta 1.	Matrix metallopeptidase 9.	0.448
CTNNB1	NOTCH1	ENSMLEP00000009207	ENSMLEP00000020505	Catenin beta 1.	Notch receptor 1.	0.573
CTNNB1	SMO	ENSMLEP00000009207	ENSMLEP00000003293	Catenin beta 1.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.428
CTNNB1	YAP1	ENSMLEP00000009207	ENSMLEP00000034725	Catenin beta 1.	Yes associated protein 1.	0.872
CTNNB1	ZEB1	ENSMLEP00000009207	ENSMLEP00000033922	Catenin beta 1.	Zinc finger E-box binding homeobox 1.	0.506
DLL1	JAG1	ENSMLEP00000017974	ENSMLEP00000021823	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.537
DLL1	NOTCH1	ENSMLEP00000017974	ENSMLEP00000020505	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.960
DLL1	NOTCH4	ENSMLEP00000017974	ENSMLEP00000009153	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 4.	0.771
DLL1	NOTCH4-2	ENSMLEP00000017974	ENSMLEP00000018909	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 4.	0.771