STRINGSTRING
SZT2 SZT2 TBC1D7 TBC1D7 CRYBA1 CRYBA1 SESN3 SESN3 RNF152 RNF152 PRKAA2 PRKAA2 ENSMLEP00000003823 ENSMLEP00000003823 SPAAR SPAAR SESN1 SESN1 SIRT1 SIRT1 NPRL3 NPRL3 WDR59 WDR59 NPRL2 NPRL2 CASTOR2 CASTOR2 TMEM127 TMEM127 EPM2A EPM2A BMT2 BMT2 MINAR1 MINAR1 HIF1A HIF1A FLCN FLCN SEC13 SEC13 C12orf66 C12orf66 ATM ATM SESN2 SESN2 TSC1 TSC1 SH3BP4 SH3BP4 ITFG2 ITFG2 UBR2 UBR2 STK11 STK11 KPTN KPTN MAPKAPK5 MAPKAPK5 CASTOR1 CASTOR1 RNF167 RNF167 TSC2 TSC2 UBR1 UBR1 DEPTOR DEPTOR ARNTL ARNTL FNIP1 FNIP1 WDR24 WDR24 DDIT4 DDIT4 PRKAA1 PRKAA1 ENSMLEP00000035740 ENSMLEP00000035740 AKT1S1 AKT1S1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SZT2SZT2 subunit of KICSTOR complex. (3432 aa)
TBC1D7TBC1 domain family member 7. (293 aa)
CRYBA1Crystallin beta A1; Belongs to the beta/gamma-crystallin family. (215 aa)
SESN3Sestrin 3. (530 aa)
RNF152Ring finger protein 152. (203 aa)
PRKAA2Non-specific serine/threonine protein kinase. (542 aa)
ENSMLEP00000003823Uncharacterized protein. (201 aa)
SPAARSmall regulatory polypeptide of amino acid response. (90 aa)
SESN1Sestrin 1. (551 aa)
SIRT1Sirtuin 1. (661 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (546 aa)
WDR59WD repeat domain 59. (974 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
CASTOR2Uncharacterized protein. (291 aa)
TMEM127Transmembrane protein 127. (220 aa)
EPM2AEPM2A glucan phosphatase, laforin. (172 aa)
BMT2Base methyltransferase of 25S rRNA 2 homolog. (247 aa)
MINAR1Membrane integral NOTCH2 associated receptor 1. (916 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (758 aa)
FLCNFolliculin. (515 aa)
SEC13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (368 aa)
C12orf66Chromosome 12 open reading frame 66. (470 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (2965 aa)
SESN2Sestrin 2. (450 aa)
TSC1TSC complex subunit 1. (1162 aa)
SH3BP4SH3 domain binding protein 4. (963 aa)
ITFG2Integrin alpha FG-GAP repeat containing 2. (447 aa)
UBR2E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1746 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
KPTNKaptin, actin binding protein. (410 aa)
MAPKAPK5MAPK activated protein kinase 5. (471 aa)
CASTOR1Cytosolic arginine sensor for mTORC1 subunit 1. (329 aa)
RNF167Ring finger protein 167. (351 aa)
TSC2TSC complex subunit 2. (1807 aa)
UBR1E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1749 aa)
DEPTORDEP domain containing MTOR interacting protein. (347 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (628 aa)
FNIP1Folliculin interacting protein 1. (1166 aa)
WDR24WD repeat domain 24. (895 aa)
DDIT4DNA damage inducible transcript 4. (233 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
ENSMLEP00000035740Uncharacterized protein. (185 aa)
AKT1S1AKT1 substrate 1. (276 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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