43 items (Mandrillus leucophaeus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SZT2	SZT2 subunit of KICSTOR complex. (3432 aa)
	TBC1D7	TBC1 domain family member 7. (293 aa)
	CRYBA1	Crystallin beta A1; Belongs to the beta/gamma-crystallin family. (215 aa)
	SESN3	Sestrin 3. (530 aa)
	RNF152	Ring finger protein 152. (203 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (542 aa)
	ENSMLEP00000003823	Uncharacterized protein. (201 aa)
	SPAAR	Small regulatory polypeptide of amino acid response. (90 aa)
	SESN1	Sestrin 1. (551 aa)
	SIRT1	Sirtuin 1. (661 aa)
	NPRL3	NPR3 like, GATOR1 complex subunit. (546 aa)
	WDR59	WD repeat domain 59. (974 aa)
	NPRL2	NPR2 like, GATOR1 complex subunit. (380 aa)
	CASTOR2	Uncharacterized protein. (291 aa)
	TMEM127	Transmembrane protein 127. (220 aa)
	EPM2A	EPM2A glucan phosphatase, laforin. (172 aa)
	BMT2	Base methyltransferase of 25S rRNA 2 homolog. (247 aa)
	MINAR1	Membrane integral NOTCH2 associated receptor 1. (916 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (758 aa)
	FLCN	Folliculin. (515 aa)
	SEC13	SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (368 aa)
	C12orf66	Chromosome 12 open reading frame 66. (470 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (2965 aa)
	SESN2	Sestrin 2. (450 aa)
	TSC1	TSC complex subunit 1. (1162 aa)
	SH3BP4	SH3 domain binding protein 4. (963 aa)
	ITFG2	Integrin alpha FG-GAP repeat containing 2. (447 aa)
	UBR2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1746 aa)
	STK11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
	KPTN	Kaptin, actin binding protein. (410 aa)
	MAPKAPK5	MAPK activated protein kinase 5. (471 aa)
	CASTOR1	Cytosolic arginine sensor for mTORC1 subunit 1. (329 aa)
	RNF167	Ring finger protein 167. (351 aa)
	TSC2	TSC complex subunit 2. (1807 aa)
	UBR1	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1749 aa)
	DEPTOR	DEP domain containing MTOR interacting protein. (347 aa)
	ARNTL	Aryl hydrocarbon receptor nuclear translocator like. (628 aa)
	FNIP1	Folliculin interacting protein 1. (1166 aa)
	WDR24	WD repeat domain 24. (895 aa)
	DDIT4	DNA damage inducible transcript 4. (233 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (559 aa)
	ENSMLEP00000035740	Uncharacterized protein. (185 aa)
	AKT1S1	AKT1 substrate 1. (276 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1S1	DEPTOR	ENSMLEP00000036090	ENSMLEP00000030581	AKT1 substrate 1.	DEP domain containing MTOR interacting protein.	0.929
AKT1S1	PRKAA1	ENSMLEP00000036090	ENSMLEP00000034493	AKT1 substrate 1.	Non-specific serine/threonine protein kinase.	0.767
AKT1S1	PRKAA2	ENSMLEP00000036090	ENSMLEP00000003668	AKT1 substrate 1.	Non-specific serine/threonine protein kinase.	0.767
AKT1S1	TSC1	ENSMLEP00000036090	ENSMLEP00000025461	AKT1 substrate 1.	TSC complex subunit 1.	0.483
AKT1S1	TSC2	ENSMLEP00000036090	ENSMLEP00000030201	AKT1 substrate 1.	TSC complex subunit 2.	0.491
ARNTL	HIF1A	ENSMLEP00000031745	ENSMLEP00000016423	Aryl hydrocarbon receptor nuclear translocator like.	Hypoxia inducible factor 1 subunit alpha.	0.756
ARNTL	SIRT1	ENSMLEP00000031745	ENSMLEP00000005263	Aryl hydrocarbon receptor nuclear translocator like.	Sirtuin 1.	0.712
ATM	PRKAA1	ENSMLEP00000023761	ENSMLEP00000034493	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Non-specific serine/threonine protein kinase.	0.507
ATM	SIRT1	ENSMLEP00000023761	ENSMLEP00000005263	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Sirtuin 1.	0.487
ATM	STK11	ENSMLEP00000023761	ENSMLEP00000027380	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine kinase 11; Belongs to the protein kinase superfamily.	0.516
BMT2	C12orf66	ENSMLEP00000012891	ENSMLEP00000019963	Base methyltransferase of 25S rRNA 2 homolog.	Chromosome 12 open reading frame 66.	0.832
BMT2	ENSMLEP00000003823	ENSMLEP00000012891	ENSMLEP00000003823	Base methyltransferase of 25S rRNA 2 homolog.	Uncharacterized protein.	0.933
BMT2	ITFG2	ENSMLEP00000012891	ENSMLEP00000027212	Base methyltransferase of 25S rRNA 2 homolog.	Integrin alpha FG-GAP repeat containing 2.	0.752
BMT2	KPTN	ENSMLEP00000012891	ENSMLEP00000028865	Base methyltransferase of 25S rRNA 2 homolog.	Kaptin, actin binding protein.	0.657
BMT2	NPRL2	ENSMLEP00000012891	ENSMLEP00000008079	Base methyltransferase of 25S rRNA 2 homolog.	NPR2 like, GATOR1 complex subunit.	0.665
BMT2	NPRL3	ENSMLEP00000012891	ENSMLEP00000006387	Base methyltransferase of 25S rRNA 2 homolog.	NPR3 like, GATOR1 complex subunit.	0.650
BMT2	SESN2	ENSMLEP00000012891	ENSMLEP00000024348	Base methyltransferase of 25S rRNA 2 homolog.	Sestrin 2.	0.483
C12orf66	BMT2	ENSMLEP00000019963	ENSMLEP00000012891	Chromosome 12 open reading frame 66.	Base methyltransferase of 25S rRNA 2 homolog.	0.832
C12orf66	CASTOR1	ENSMLEP00000019963	ENSMLEP00000029556	Chromosome 12 open reading frame 66.	Cytosolic arginine sensor for mTORC1 subunit 1.	0.465
C12orf66	CASTOR2	ENSMLEP00000019963	ENSMLEP00000009292	Chromosome 12 open reading frame 66.	Uncharacterized protein.	0.654