STRINGSTRING
WNT5A WNT5A ENSMLEP00000003215 ENSMLEP00000003215 LOC105532501 LOC105532501 MTOR MTOR ENSMLEP00000005745 ENSMLEP00000005745 ITGB1BP1 ITGB1BP1 PARK7 PARK7 NTRK3 NTRK3 PDPK1 PDPK1 ADRA2B ADRA2B ENSMLEP00000006908 ENSMLEP00000006908 NTF3 NTF3 LOC105553468 LOC105553468 IGF1 IGF1 PINK1 PINK1 PDGFB PDGFB ENSMLEP00000033803 ENSMLEP00000033803 ADRA2C ADRA2C SRC SRC SLC1A1 SLC1A1 ADRA2A ADRA2A GAS6 GAS6 PPIA PPIA OSBPL8 OSBPL8 CCDC88A CCDC88A FGF1 FGF1 PRKCZ PRKCZ INSR INSR IL18 IL18 DYNAP DYNAP NRG1 NRG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ENSMLEP00000003215Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (194 aa)
LOC105532501Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (175 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
ENSMLEP00000005745Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (165 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
NTRK3Tyrosine-protein kinase receptor. (781 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (529 aa)
ADRA2BAdrenoceptor alpha 2B. (447 aa)
ENSMLEP00000006908Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (165 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (264 aa)
LOC105553468Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (165 aa)
IGF1Insulin like growth factor 1. (159 aa)
PINK1PTEN induced kinase 1. (545 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ENSMLEP00000033803DJ-1_PfpI domain-containing protein. (153 aa)
ADRA2CAdrenoceptor alpha 2C. (302 aa)
SRCTyrosine-protein kinase. (542 aa)
SLC1A1Solute carrier family 1 member 1. (524 aa)
ADRA2AAdrenoceptor alpha 2A. (310 aa)
GAS6Growth arrest specific 6. (640 aa)
PPIAPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (142 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (889 aa)
CCDC88ACoiled-coil domain containing 88A. (1870 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
INSRTyrosine-protein kinase receptor. (1301 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
DYNAPDynactin associated protein. (210 aa)
NRG1Neuregulin 1. (713 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.