STRINGSTRING
PIK3CA PIK3CA BAIAP2 BAIAP2 ENSMLEP00000009841 ENSMLEP00000009841 IRS1 IRS1 INSRR INSRR SLC2A4 SLC2A4 SLC27A1 SLC27A1 OGT OGT PDPK1 PDPK1 SRSF5 SRSF5 EGR1 EGR1 ENSMLEP00000013040 ENSMLEP00000013040 POTEA POTEA GHSR GHSR TNFSF10 TNFSF10 FER FER ENPP1 ENPP1 CITED1 CITED1 HSD11B2 HSD11B2 SRSF6 SRSF6 GRB14 GRB14 NCOA5 NCOA5 SRSF4 SRSF4 RPE65 RPE65 KAT2B KAT2B CSRP3 CSRP3 ENSMLEP00000015404 ENSMLEP00000015404 IGFBP1 IGFBP1 PRKCZ PRKCZ GAB1 GAB1 SLC25A33 SLC25A33 LOC105530298 LOC105530298 EEF2K EEF2K EPRS1 EPRS1 ENSMLEP00000017280 ENSMLEP00000017280 INSR INSR OTOP1 OTOP1 GRB2 GRB2 GHRHR GHRHR SYAP1 SYAP1 SLC27A4 SLC27A4 ADIPOQ ADIPOQ PTPRA PTPRA PRKDC PRKDC CAPN10 CAPN10 GAL GAL SLC29A2 SLC29A2 ACVR1C ACVR1C EIF4EBP2 EIF4EBP2 PPARA PPARA RB1 RB1 AKT2 AKT2 HDAC9 HDAC9 ENSMLEP00000022796 ENSMLEP00000022796 LPIN3 LPIN3 AGRP AGRP TRPV4 TRPV4 IGF1R IGF1R BCAR3 BCAR3 SESN2 SESN2 FOXC2 FOXC2 GSK3B GSK3B CCDC144NL CCDC144NL EGR2 EGR2 SORBS1 SORBS1 TSC1 TSC1 VPS13C VPS13C KLF15 KLF15 LPIN1 LPIN1 PHIP PHIP PDK4 PDK4 ENSMLEP00000025945 ENSMLEP00000025945 MYO5A MYO5A CDK4 CDK4 ANKRD26 ANKRD26 RETN RETN RAB15 RAB15 ENSMLEP00000027728 ENSMLEP00000027728 AKT1 AKT1 DNAI1 DNAI1 CRY1 CRY1 KBTBD2 KBTBD2 INPP5K INPP5K GPT GPT USF1 USF1 SOGA1 SOGA1 ENSMLEP00000028984 ENSMLEP00000028984 PTPN2 PTPN2 STAT1 STAT1 SELENOS SELENOS HMGCS2 HMGCS2 TBC1D4 TBC1D4 RAB10 RAB10 XBP1 XBP1 GCK GCK PIK3R3 PIK3R3 PRKCI PRKCI SREBF1 SREBF1 LOC105548563 LOC105548563 RAB31 RAB31 LPIN2 LPIN2 PFKFB1 PFKFB1 PRLH PRLH FOXO4 FOXO4 ZNF106 ZNF106 C2CD5 C2CD5 KL KL RAB8A RAB8A ZBTB7B ZBTB7B IDE IDE STXBP3 STXBP3 APC APC BCAR1 BCAR1 PIK3R1 PIK3R1 GPLD1 GPLD1 GCLC GCLC LEP LEP GRB10 GRB10 TRIB3 TRIB3 PDK2 PDK2 SRC SRC MAX MAX RAB13 RAB13 DENND4C DENND4C PNPLA3 PNPLA3 PCK2 PCK2 SP1 SP1 RHOQ RHOQ SCAP SCAP MEAK7 MEAK7 ZDHHC7 ZDHHC7 APRT APRT ERRFI1 ERRFI1 MAPK14 MAPK14 TRARG1 TRARG1 EIF6 EIF6 PPARG PPARG CPEB1 CPEB1 RAB12 RAB12 CRY2 CRY2 PCSK9 PCSK9 PCK1 PCK1 PDE3B PDE3B KCNQ1 KCNQ1 UCP3 UCP3 ZFP36L1 ZFP36L1 ENSMLEP00000040511 ENSMLEP00000040511 SLC39A14 SLC39A14 CYFIP1 CYFIP1 OTC OTC ENSMLEP00000000301 ENSMLEP00000000301 SORT1 SORT1 ENSMLEP00000000526 ENSMLEP00000000526 SMARCC1 SMARCC1 SESN3 SESN3 IGF2 IGF2 ABCC8 ABCC8 LYN LYN PIK3R2 PIK3R2 LOC105541640 LOC105541640 INPPL1 INPPL1 STXBP4 STXBP4 PARP1 PARP1 SLC9A1 SLC9A1 SLC2A8 SLC2A8 SLC2A1 SLC2A1 PLA2G1B PLA2G1B APPL1 APPL1 GCNT1 GCNT1 SLC22A12 SLC22A12 HADHA HADHA EPM2AIP1 EPM2AIP1 SIRT1 SIRT1 MTOR MTOR PTPN1 PTPN1 CPEB2 CPEB2 ADM ADM RPS6KB1 RPS6KB1 WDTC1 WDTC1 HADH HADH FBP1 FBP1 ENSMLEP00000008862 ENSMLEP00000008862 IRS4 IRS4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
BAIAP2BAI1 associated protein 2. (490 aa)
ENSMLEP00000009841Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (310 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
INSRRTyrosine-protein kinase receptor. (1301 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
SLC27A1Solute carrier family 27 member 1. (626 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (529 aa)
SRSF5Serine and arginine rich splicing factor 5. (272 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
ENSMLEP00000013040Uncharacterized protein. (131 aa)
POTEAPOTE ankyrin domain family member A. (526 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (281 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (845 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
HSD11B2Hydroxysteroid 11-beta dehydrogenase 2. (387 aa)
SRSF6Serine and arginine rich splicing factor 6. (214 aa)
GRB14Growth factor receptor bound protein 14. (491 aa)
NCOA5Nuclear receptor coactivator 5. (579 aa)
SRSF4Serine and arginine rich splicing factor 4. (494 aa)
RPE65Retinoid isomerohydrolase RPE65. (533 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (778 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
ENSMLEP00000015404Fork-head domain-containing protein. (531 aa)
IGFBP1Insulin like growth factor binding protein 1. (260 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
SLC25A33Solute carrier family 25 member 33; Belongs to the mitochondrial carrier (TC 2.A.29) family. (321 aa)
LOC105530298Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (679 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
EPRS1Glutamyl-prolyl-tRNA synthetase. (1487 aa)
ENSMLEP00000017280Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (149 aa)
INSRTyrosine-protein kinase receptor. (1301 aa)
OTOP1Otopetrin 1. (610 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
SYAP1Synapse associated protein 1. (350 aa)
SLC27A4Solute carrier family 27 member 4. (651 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (249 aa)
PTPRAReceptor-type tyrosine-protein phosphatase alpha. (805 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit. (3556 aa)
CAPN10Calpain 10; Belongs to the peptidase C2 family. (672 aa)
GALGalanin and GMAP prepropeptide. (131 aa)
SLC29A2Solute carrier family 29 member 2. (451 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E binding protein 2. (71 aa)
PPARAPeroxisome proliferator activated receptor alpha. (365 aa)
RB1RB transcriptional corepressor 1. (891 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
ENSMLEP00000022796Uncharacterized protein. (111 aa)
LPIN3Lipin 3. (852 aa)
AGRPAgouti related neuropeptide. (132 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
IGF1RTyrosine-protein kinase receptor. (1281 aa)
BCAR3BCAR3 adaptor protein, NSP family member. (825 aa)
SESN2Sestrin 2. (450 aa)
FOXC2Forkhead box C2. (254 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
CCDC144NLUncharacterized protein. (1413 aa)
EGR2Early growth response 2. (476 aa)
SORBS1Sorbin and SH3 domain containing 1. (1294 aa)
TSC1TSC complex subunit 1. (1162 aa)
VPS13CVacuolar protein sorting 13 homolog C. (3754 aa)
KLF15Kruppel like factor 15. (416 aa)
LPIN1Lipin 1. (974 aa)
PHIPPleckstrin homology domain interacting protein. (1771 aa)
PDK4Protein-serine/threonine kinase. (411 aa)
ENSMLEP00000025945Uncharacterized protein. (137 aa)
MYO5AMyosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1846 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
ANKRD26Ankyrin repeat domain 26. (1694 aa)
RETNResistin. (108 aa)
RAB15RAB15, member RAS oncogene family. (257 aa)
ENSMLEP00000027728Uncharacterized protein. (105 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
DNAI1Dynein axonemal intermediate chain 1. (704 aa)
CRY1Cryptochrome circadian regulator 1. (586 aa)
KBTBD2Kelch repeat and BTB domain containing 2. (623 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (448 aa)
GPTGlutamic--pyruvic transaminase. (496 aa)
USF1Upstream transcription factor 1. (310 aa)
SOGA1Suppressor of glucose, autophagy associated 1. (1474 aa)
ENSMLEP00000028984Uncharacterized protein. (196 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (403 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
SELENOSSelenoprotein S. (211 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
TBC1D4TBC1 domain family member 4. (1132 aa)
RAB10RAB10, member RAS oncogene family. (200 aa)
XBP1X-box binding protein 1. (204 aa)
GCKPhosphotransferase. (466 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (583 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1124 aa)
LOC105548563Uncharacterized protein. (245 aa)
RAB31RAB31, member RAS oncogene family. (259 aa)
LPIN2Lipin 2. (896 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (471 aa)
PRLHProlactin releasing hormone. (87 aa)
FOXO4Forkhead box O4. (505 aa)
ZNF106Zinc finger protein 106. (1883 aa)
C2CD5C2 calcium dependent domain containing 5. (1084 aa)
KLKlotho; Belongs to the glycosyl hydrolase 1 family. (645 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (573 aa)
IDEInsulin degrading enzyme; Belongs to the peptidase M16 family. (1019 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
APCAPC regulator of WNT signaling pathway. (2806 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (916 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (794 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (587 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
GRB10Growth factor receptor bound protein 10. (593 aa)
TRIB3Tribbles pseudokinase 3. (385 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
SRCTyrosine-protein kinase. (542 aa)
MAXMYC associated factor X. (160 aa)
RAB13Uncharacterized protein. (203 aa)
DENND4CDENN domain containing 4C. (1927 aa)
PNPLA3Patatin like phospholipase domain containing 3. (462 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (645 aa)
SP1Uncharacterized protein. (661 aa)
RHOQRas homolog family member Q. (192 aa)
SCAPSREBF chaperone. (1279 aa)
MEAK7MTOR associated protein, eak-7 homolog. (456 aa)
ZDHHC7Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (344 aa)
APRTAdenine phosphoribosyltransferase. (157 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (462 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
TRARG1Trafficking regulator of GLUT4 (SLC2A4) 1. (177 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (517 aa)
CPEB1Cytoplasmic polyadenylation element binding protein 1. (620 aa)
RAB12Uncharacterized protein. (65 aa)
CRY2Cryptochrome circadian regulator 2. (614 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9. (692 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
PDE3BPhosphodiesterase. (1113 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (592 aa)
UCP3Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (312 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
ENSMLEP00000040511Uncharacterized protein. (645 aa)
SLC39A14Solute carrier family 39 member 14. (410 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1233 aa)
OTCOrnithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (328 aa)
ENSMLEP00000000301ANK_REP_REGION domain-containing protein. (297 aa)
SORT1Sortilin. (676 aa)
ENSMLEP00000000526Uncharacterized protein. (64 aa)
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1077 aa)
SESN3Sestrin 3. (530 aa)
IGF2Insulin like growth factor 2. (236 aa)
ABCC8ATP binding cassette subfamily C member 8. (1582 aa)
LYNTyrosine-protein kinase. (470 aa)
PIK3R2Uncharacterized protein. (587 aa)
LOC105541640Uncharacterized protein. (526 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1235 aa)
STXBP4Syntaxin binding protein 4. (555 aa)
PARP1Poly [ADP-ribose] polymerase. (1017 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
SLC2A8Solute carrier family 2 member 8; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (389 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa)
PLA2G1BPhospholipase A(2). (148 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (694 aa)
GCNT1Glucosaminyl (N-acetyl) transferase 1. (428 aa)
SLC22A12Solute carrier family 22 member 12. (553 aa)
HADHAHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
EPM2AIP1EPM2A interacting protein 1. (607 aa)
SIRT1Sirtuin 1. (661 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
CPEB2Uncharacterized protein. (480 aa)
ADMAdrenomedullin. (200 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
WDTC1WD and tetratricopeptide repeats 1. (550 aa)
HADHHydroxyacyl-CoA dehydrogenase. (331 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (298 aa)
ENSMLEP00000008862Uncharacterized protein. (116 aa)
IRS4Insulin receptor substrate 4. (1245 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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