(23 nodes) Megakaryocyte development network (Mandrillus leucophaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FLNA	Filamin A. (2565 aa)
	MPIG6B	Megakaryocyte and platelet inhibitory receptor G6b. (241 aa)
	FLI1	Fli-1 proto-oncogene, ETS transcription factor. (453 aa)
	GP1BA	Uncharacterized protein. (644 aa)
	ENSMLEP00000035415	Uncharacterized protein. (519 aa)
	WASF2	WASP family member 2. (498 aa)
	KIT	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
	EP300	E1A binding protein p300. (2411 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1575 aa)
	PIP4K2A	Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (358 aa)
	GP9	Glycoprotein IX platelet. (177 aa)
	SRF	Serum response factor. (434 aa)
	ZNF385A	Zinc finger protein 385A. (414 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (656 aa)
	ENSMLEP00000012128	Uncharacterized protein. (234 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
	SH2B3	SH2B adaptor protein 3. (365 aa)
	THPO	Thrombopoietin. (351 aa)
	MEIS1	Meis homeobox 1. (463 aa)
	ABI1	Abl interactor 1. (469 aa)
	ENSMLEP00000025633	Uncharacterized protein. (144 aa)
	VPS33B	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (617 aa)
	ENSMLEP00000028290	Uncharacterized protein. (441 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABI1	WASF2	ENSMLEP00000024155	ENSMLEP00000034975	Abl interactor 1.	WASP family member 2.	0.978
ENSMLEP00000012128	KIT	ENSMLEP00000012128	ENSMLEP00000031791	Uncharacterized protein.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.854
ENSMLEP00000012128	MPIG6B	ENSMLEP00000012128	ENSMLEP00000037731	Uncharacterized protein.	Megakaryocyte and platelet inhibitory receptor G6b.	0.638
ENSMLEP00000012128	PTPN6	ENSMLEP00000012128	ENSMLEP00000014698	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.793
ENSMLEP00000025633	EP300	ENSMLEP00000025633	ENSMLEP00000031242	Uncharacterized protein.	E1A binding protein p300.	0.521
ENSMLEP00000028290	KIT	ENSMLEP00000028290	ENSMLEP00000031791	Uncharacterized protein.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.595
ENSMLEP00000028290	MPIG6B	ENSMLEP00000028290	ENSMLEP00000037731	Uncharacterized protein.	Megakaryocyte and platelet inhibitory receptor G6b.	0.638
ENSMLEP00000028290	PTPN6	ENSMLEP00000028290	ENSMLEP00000014698	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.441
ENSMLEP00000035415	KIT	ENSMLEP00000035415	ENSMLEP00000031791	Uncharacterized protein.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.595
ENSMLEP00000035415	MPIG6B	ENSMLEP00000035415	ENSMLEP00000037731	Uncharacterized protein.	Megakaryocyte and platelet inhibitory receptor G6b.	0.638
ENSMLEP00000035415	PTPN6	ENSMLEP00000035415	ENSMLEP00000014698	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.436
EP300	ENSMLEP00000025633	ENSMLEP00000031242	ENSMLEP00000025633	E1A binding protein p300.	Uncharacterized protein.	0.521
EP300	MED1	ENSMLEP00000031242	ENSMLEP00000028914	E1A binding protein p300.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.742
FLNA	GP1BA	ENSMLEP00000027918	ENSMLEP00000035547	Filamin A.	Uncharacterized protein.	0.960
FLNA	GP9	ENSMLEP00000027918	ENSMLEP00000001659	Filamin A.	Glycoprotein IX platelet.	0.437
GP1BA	FLNA	ENSMLEP00000035547	ENSMLEP00000027918	Uncharacterized protein.	Filamin A.	0.960
GP1BA	GP9	ENSMLEP00000035547	ENSMLEP00000001659	Uncharacterized protein.	Glycoprotein IX platelet.	0.986
GP9	FLNA	ENSMLEP00000001659	ENSMLEP00000027918	Glycoprotein IX platelet.	Filamin A.	0.437
GP9	GP1BA	ENSMLEP00000001659	ENSMLEP00000035547	Glycoprotein IX platelet.	Uncharacterized protein.	0.986
KIT	ENSMLEP00000012128	ENSMLEP00000031791	ENSMLEP00000012128	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Uncharacterized protein.	0.854