(51 nodes) Cellular response to glucose starvation network (Mandrillus leucophaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (596 aa)
	CHKA	Choline kinase alpha. (410 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	ATF4	Activating transcription factor 4. (351 aa)
	SIRT1	Sirtuin 1. (661 aa)
	SESN1	Sestrin 1. (551 aa)
	UPP1	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (314 aa)
	SLC2A1	Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (542 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1012 aa)
	BHLHA15	Basic helix-loop-helix family member a15. (191 aa)
	SESN3	Sestrin 3. (530 aa)
	SZT2	SZT2 subunit of KICSTOR complex. (3432 aa)
	ATG14	Autophagy related 14. (486 aa)
	CPEB4	Cytoplasmic polyadenylation element binding protein 4. (729 aa)
	PRKAG3	Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
	SIK1	Uncharacterized protein. (764 aa)
	ENSMLEP00000013771	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (104 aa)
	ENSMLEP00000014595	Uncharacterized protein. (117 aa)
	ENSMLEP00000014760	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (94 aa)
	PICK1	Protein interacting with PRKCA 1. (398 aa)
	BRSK2	BR serine/threonine kinase 2. (710 aa)
	SLC7A5	Solute carrier family 7 member 5. (388 aa)
	PLIN3	Perilipin; Belongs to the perilipin family. (427 aa)
	TBL2	Transducin beta like 2. (446 aa)
	LOC105533891	Perilipin; Belongs to the perilipin family. (437 aa)
	IMPACT	Impact RWD domain protein. (320 aa)
	C12orf66	Chromosome 12 open reading frame 66. (470 aa)
	IFI16	Interferon gamma inducible protein 16. (729 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (601 aa)
	ENSMLEP00000021070	C2 PI3K-type domain-containing protein; Belongs to the PI3/PI4-kinase family. (201 aa)
	KAT5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
	RRP8	Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (456 aa)
	PLIN2	Perilipin; Belongs to the perilipin family. (420 aa)
	ENSMLEP00000022361	Uncharacterized protein; Belongs to the heat shock protein 70 family. (580 aa)
	HSPA5	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
	SESN2	Sestrin 2. (450 aa)
	MYBBP1A	MYB binding protein 1a. (1329 aa)
	PRKAG2	Protein kinase AMP-activated non-catalytic subunit gamma 2. (506 aa)
	ITFG2	Integrin alpha FG-GAP repeat containing 2. (447 aa)
	BRSK1	BR serine/threonine kinase 1. (763 aa)
	KPTN	Kaptin, actin binding protein. (410 aa)
	MTMR3	Myotubularin related protein 3. (1207 aa)
	NIM1K	NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. (436 aa)
	XBP1	X-box binding protein 1. (204 aa)
	NUAK1	NUAK family kinase 1. (656 aa)
	PRKAG1	Protein kinase AMP-activated non-catalytic subunit gamma 1. (326 aa)
	NUAK2	NUAK family kinase 2. (672 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (559 aa)
	PIK3R4	Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF4	EIF2AK3	ENSMLEP00000005434	ENSMLEP00000002467	Activating transcription factor 4.	Eukaryotic translation initiation factor 2 alpha kinase 3.	0.943
ATF4	ENSMLEP00000022361	ENSMLEP00000005434	ENSMLEP00000022361	Activating transcription factor 4.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.573
ATF4	HSPA5	ENSMLEP00000005434	ENSMLEP00000022843	Activating transcription factor 4.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.628
ATF4	NFE2L2	ENSMLEP00000005434	ENSMLEP00000037194	Activating transcription factor 4.	Nuclear factor, erythroid 2 like 2.	0.571
ATF4	XBP1	ENSMLEP00000005434	ENSMLEP00000030666	Activating transcription factor 4.	X-box binding protein 1.	0.686
ATG14	BCL2	ENSMLEP00000013055	ENSMLEP00000005872	Autophagy related 14.	BCL2 apoptosis regulator.	0.487
ATG14	ENSMLEP00000013771	ENSMLEP00000013055	ENSMLEP00000013771	Autophagy related 14.	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.975
ATG14	ENSMLEP00000014760	ENSMLEP00000013055	ENSMLEP00000014760	Autophagy related 14.	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.975
ATG14	ENSMLEP00000021070	ENSMLEP00000013055	ENSMLEP00000021070	Autophagy related 14.	C2 PI3K-type domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.975
ATG14	PIK3R4	ENSMLEP00000013055	ENSMLEP00000035809	Autophagy related 14.	Phosphoinositide-3-kinase regulatory subunit 4.	0.998
ATG14	PRKAA1	ENSMLEP00000013055	ENSMLEP00000034493	Autophagy related 14.	Non-specific serine/threonine protein kinase.	0.560
ATG14	PRKAA2	ENSMLEP00000013055	ENSMLEP00000003668	Autophagy related 14.	Non-specific serine/threonine protein kinase.	0.558
ATG14	PRKAG2	ENSMLEP00000013055	ENSMLEP00000027083	Autophagy related 14.	Protein kinase AMP-activated non-catalytic subunit gamma 2.	0.530
BCL2	ATG14	ENSMLEP00000005872	ENSMLEP00000013055	BCL2 apoptosis regulator.	Autophagy related 14.	0.487
BCL2	SIRT1	ENSMLEP00000005872	ENSMLEP00000005263	BCL2 apoptosis regulator.	Sirtuin 1.	0.616
BCL2	TP53	ENSMLEP00000005872	ENSMLEP00000037099	BCL2 apoptosis regulator.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.994
C12orf66	ITFG2	ENSMLEP00000019963	ENSMLEP00000027212	Chromosome 12 open reading frame 66.	Integrin alpha FG-GAP repeat containing 2.	0.996
C12orf66	KPTN	ENSMLEP00000019963	ENSMLEP00000028865	Chromosome 12 open reading frame 66.	Kaptin, actin binding protein.	0.994
C12orf66	SESN1	ENSMLEP00000019963	ENSMLEP00000005170	Chromosome 12 open reading frame 66.	Sestrin 1.	0.501
C12orf66	SESN2	ENSMLEP00000019963	ENSMLEP00000024348	Chromosome 12 open reading frame 66.	Sestrin 2.	0.585