STRINGSTRING
KLF15 KLF15 SLC39A14 SLC39A14 G6PC G6PC PDK3 PDK3 BACE2 BACE2 WFS1 WFS1 MBD5 MBD5 PCK1 PCK1 PYGL PYGL CRY2 CRY2 G6PC2 G6PC2 SIN3A SIN3A GCKR GCKR CSMD1 CSMD1 SLC12A6 SLC12A6 GPER1 GPER1 PCK2 PCK2 MCU MCU CARTPT CARTPT SELENOT SELENOT NPTX1 NPTX1 AQP4 AQP4 ENSMLEP00000035415 ENSMLEP00000035415 PDK2 PDK2 LEP LEP PRKAA1 PRKAA1 GCLC GCLC ENSMLEP00000033803 ENSMLEP00000033803 PIK3R1 PIK3R1 STXBP3 STXBP3 ADIPOR1 ADIPOR1 RAB11FIP2 RAB11FIP2 RPS6 RPS6 ENSMLEP00000031736 ENSMLEP00000031736 MTNR1B MTNR1B HNF1A HNF1A GCK GCK SLC16A1 SLC16A1 XBP1 XBP1 STXBP5L STXBP5L DHPS DHPS SERPINF1 SERPINF1 LOC105549202 LOC105549202 PTPN2 PTPN2 FGF21 FGF21 SLC8B1 SLC8B1 PAX2 PAX2 MLXIPL MLXIPL TREM2 TREM2 USF1 USF1 ENSMLEP00000028290 ENSMLEP00000028290 INPP5K INPP5K CRY1 CRY1 TFAP2B TFAP2B AKT1 AKT1 STK11 STK11 FN1 FN1 HNF4A HNF4A SLC37A4 SLC37A4 HECTD4 HECTD4 SLC29A1 SLC29A1 GCGR GCGR ANKRD26 ANKRD26 ENSMLEP00000025945 ENSMLEP00000025945 PDK4 PDK4 ENSMLEP00000025294 ENSMLEP00000025294 ENSMLEP00000024959 ENSMLEP00000024959 FKBP1B FKBP1B CCDC144NL CCDC144NL ASPSCR1 ASPSCR1 NR1D1 NR1D1 FOXA3 FOXA3 SESN2 SESN2 IGF1R IGF1R GRIK5 GRIK5 SUCNR1 SUCNR1 TRPV4 TRPV4 GCLM GCLM RESP18 RESP18 GCG GCG CYP7A1 CYP7A1 MEN1 MEN1 GAS6 GAS6 ENSMLEP00000021503 ENSMLEP00000021503 CSMD2 CSMD2 ENSMLEP00000021430 ENSMLEP00000021430 CYB5R4 CYB5R4 ZNF236 ZNF236 ALOX5 ALOX5 IGFBP5 IGFBP5 CAV3 CAV3 PPARGC1A PPARGC1A TH TH DBH DBH IL6 IL6 PIK3CA PIK3CA PTCH1 PTCH1 RPH3AL RPH3AL ERN1 ERN1 FOXK2 FOXK2 NMB NMB ADIPOQ ADIPOQ ZBTB20 ZBTB20 GHRHR GHRHR CCN4 CCN4 FAM3B FAM3B RACK1 RACK1 FBN1 FBN1 RFX6 RFX6 INSR INSR FABP5 FABP5 ADIPOR2 ADIPOR2 CRTC2 CRTC2 PTPRN PTPRN HIF1A HIF1A PDX1 PDX1 TCF7L2 TCF7L2 PLSCR3 PLSCR3 HK3 HK3 ENSMLEP00000015404 ENSMLEP00000015404 CCDC186 CCDC186 CSRP3 CSRP3 RBP4 RBP4 NCOA5 NCOA5 PARK7 PARK7 CYBA CYBA LRRC8A LRRC8A SIRT6 SIRT6 POTEA POTEA ENSMLEP00000013040 ENSMLEP00000013040 FBN2 FBN2 STAT3 STAT3 RAB11FIP5 RAB11FIP5 APPL2 APPL2 HK1 HK1 ENSMLEP00000012128 ENSMLEP00000012128 PAX6 PAX6 NUCKS1 NUCKS1 SLC2A4 SLC2A4 IRS1 IRS1 SIDT2 SIDT2 PPP3CA PPP3CA TWNK TWNK ENSMLEP00000008862 ENSMLEP00000008862 CASR CASR RBM4B RBM4B GATA4 GATA4 FGFR4 FGFR4 SMAD4 SMAD4 GPR1 GPR1 FOXK1 FOXK1 CLTRN CLTRN TJP1 TJP1 PTPN11 PTPN11 FFAR2 FFAR2 NR1H4 NR1H4 ADCY8 ADCY8 SIRT1 SIRT1 HKDC1 HKDC1 LEPR LEPR PRKAA2 PRKAA2 BAD BAD PFKM PFKM ADGRF5 ADGRF5 HK2 HK2 LIN28A LIN28A NEUROD1 NEUROD1 SRF SRF ENSMLEP00000002412 ENSMLEP00000002412 POMC POMC NGFR NGFR FFAR1 FFAR1 DUPD1 DUPD1 PIK3R2 PIK3R2 GJB6 GJB6 OAS1 OAS1 TRA2B TRA2B CNR2 CNR2 BHLHA15 BHLHA15 ABCC8 ABCC8 SESN3 SESN3 KLF7 KLF7 SLC12A7 SLC12A7 AGER AGER ENSMLEP00000000301 ENSMLEP00000000301 CPB2 CPB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLF15Kruppel like factor 15. (416 aa)
SLC39A14Solute carrier family 39 member 14. (410 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
PDK3Protein-serine/threonine kinase. (415 aa)
BACE2Beta-secretase 2; Belongs to the peptidase A1 family. (460 aa)
WFS1Wolframin ER transmembrane glycoprotein. (890 aa)
MBD5Methyl-CpG binding domain protein 5. (1724 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (766 aa)
CRY2Cryptochrome circadian regulator 2. (614 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (354 aa)
SIN3ASIN3 transcription regulator family member A. (1273 aa)
GCKRGlucokinase regulator. (625 aa)
CSMD1CUB and Sushi multiple domains 1. (3082 aa)
SLC12A6Solute carrier family 12 member 6. (1150 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (400 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (645 aa)
MCUMitochondrial calcium uniporter. (318 aa)
CARTPTCART prepropeptide. (116 aa)
SELENOTSelenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (189 aa)
NPTX1Neuronal pentraxin 1. (370 aa)
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
ENSMLEP00000035415Uncharacterized protein. (519 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (587 aa)
ENSMLEP00000033803DJ-1_PfpI domain-containing protein. (153 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
RAB11FIP2RAB11 family interacting protein 2. (532 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (218 aa)
ENSMLEP0000003173640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (222 aa)
MTNR1BMelatonin receptor 1B; Belongs to the G-protein coupled receptor 1 family. (362 aa)
HNF1AHNF1 homeobox A. (662 aa)
GCKPhosphotransferase. (466 aa)
SLC16A1Solute carrier family 16 member 1. (500 aa)
XBP1X-box binding protein 1. (204 aa)
STXBP5LSyntaxin binding protein 5 like. (1186 aa)
DHPSUncharacterized protein. (369 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (418 aa)
LOC10554920240S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (244 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (403 aa)
FGF21Fibroblast growth factor 21; Belongs to the heparin-binding growth factors family. (174 aa)
SLC8B1Solute carrier family 8 member B1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (593 aa)
PAX2Paired box 2. (407 aa)
MLXIPLMLX interacting protein like. (784 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (231 aa)
USF1Upstream transcription factor 1. (310 aa)
ENSMLEP00000028290Uncharacterized protein. (441 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (448 aa)
CRY1Cryptochrome circadian regulator 1. (586 aa)
TFAP2BTranscription factor AP-2 beta. (460 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
FN1Fibronectin 1. (2384 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (464 aa)
SLC37A4Solute carrier family 37 member 4. (451 aa)
HECTD4HECT domain E3 ubiquitin protein ligase 4. (4379 aa)
SLC29A1Solute carrier family 29 member 1 (Augustine blood group). (456 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (491 aa)
ANKRD26Ankyrin repeat domain 26. (1694 aa)
ENSMLEP00000025945Uncharacterized protein. (137 aa)
PDK4Protein-serine/threonine kinase. (411 aa)
ENSMLEP00000025294Uncharacterized protein. (109 aa)
ENSMLEP00000024959Pannexin_like domain-containing protein. (150 aa)
FKBP1BPeptidylprolyl isomerase. (95 aa)
CCDC144NLUncharacterized protein. (1413 aa)
ASPSCR1ASPSCR1 tether for SLC2A4, UBX domain containing. (508 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
FOXA3Forkhead box A3. (350 aa)
SESN2Sestrin 2. (450 aa)
IGF1RTyrosine-protein kinase receptor. (1281 aa)
GRIK5Glutamate ionotropic receptor kainate type subunit 5. (946 aa)
SUCNR1Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (325 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
GCLMGlutamate-cysteine ligase modifier subunit. (232 aa)
RESP18Regulated endocrine specific protein 18. (228 aa)
GCGGlucagon. (180 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
MEN1Menin 1. (615 aa)
GAS6Growth arrest specific 6. (640 aa)
ENSMLEP00000021503Receptor_IA-2 domain-containing protein. (461 aa)
CSMD2CUB and Sushi multiple domains 2. (3470 aa)
ENSMLEP0000002143040S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (210 aa)
CYB5R4Cytochrome b5 reductase 4. (521 aa)
ZNF236Zinc finger protein 236. (1845 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
THTyrosine hydroxylase. (549 aa)
DBHDopamine beta-hydroxylase. (620 aa)
IL6Interleukin 6. (226 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PTCH1Patched 1. (1379 aa)
RPH3ALRabphilin 3A like (without C2 domains). (358 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (959 aa)
FOXK2Forkhead box K2. (401 aa)
NMBNeuromedin B. (153 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (249 aa)
ZBTB20Zinc finger and BTB domain containing 20. (741 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
CCN4Cellular communication network factor 4. (367 aa)
FAM3BFamily with sequence similarity 3 member B. (271 aa)
RACK1Receptor for activated C kinase 1. (318 aa)
FBN1Fibrillin 1. (2883 aa)
RFX6Regulatory factor X6. (928 aa)
INSRTyrosine-protein kinase receptor. (1301 aa)
FABP5FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
CRTC2CREB regulated transcription coactivator 2. (694 aa)
PTPRNProtein tyrosine phosphatase receptor type N. (979 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (758 aa)
PDX1Pancreatic and duodenal homeobox 1. (283 aa)
TCF7L2Transcription factor 7 like 2. (555 aa)
PLSCR3Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (295 aa)
HK3Hexokinase 3. (923 aa)
ENSMLEP00000015404Fork-head domain-containing protein. (531 aa)
CCDC186Coiled-coil domain containing 186. (898 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
RBP4Retinol-binding protein; Retinol-binding protein that mediates retinol transport in blood plasma. (200 aa)
NCOA5Nuclear receptor coactivator 5. (579 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
CYBACytochrome b-245 alpha chain. (194 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (810 aa)
SIRT6Sirtuin 6. (355 aa)
POTEAPOTE ankyrin domain family member A. (526 aa)
ENSMLEP00000013040Uncharacterized protein. (131 aa)
FBN2Fibrillin 2. (2912 aa)
STAT3Signal transducer and activator of transcription. (693 aa)
RAB11FIP5FIP-RBD domain-containing protein. (1218 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (670 aa)
HK1Hexokinase 1. (921 aa)
ENSMLEP00000012128Uncharacterized protein. (234 aa)
PAX6Paired box 6. (520 aa)
NUCKS1Nuclear casein kinase and cyclin dependent kinase substrate 1. (248 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
SIDT2SID1 transmembrane family member 2. (860 aa)
PPP3CASerine/threonine-protein phosphatase. (501 aa)
TWNKTwinkle mtDNA helicase. (582 aa)
ENSMLEP00000008862Uncharacterized protein. (116 aa)
CASRCalcium sensing receptor. (1088 aa)
RBM4BRNA binding motif protein 4B. (359 aa)
GATA4GATA binding protein 4. (236 aa)
FGFR4Fibroblast growth factor receptor. (802 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GPR1G protein-coupled receptor 1. (355 aa)
FOXK1Forkhead box K1. (652 aa)
CLTRNCollectrin domain-containing protein. (222 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1738 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (656 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (330 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
SIRT1Sirtuin 1. (661 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
LEPRLeptin receptor. (1163 aa)
PRKAA2Non-specific serine/threonine protein kinase. (542 aa)
BADBCL2 associated agonist of cell death. (167 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1343 aa)
HK2Hexokinase 2. (901 aa)
LIN28ALin-28 homolog A. (209 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
SRFSerum response factor. (434 aa)
ENSMLEP00000002412Uncharacterized protein. (188 aa)
POMCProopiomelanocortin. (265 aa)
NGFRNerve growth factor receptor. (423 aa)
FFAR1Free fatty acid receptor 1. (300 aa)
DUPD1Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (219 aa)
PIK3R2Uncharacterized protein. (587 aa)
GJB6Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (261 aa)
OAS12'-5'-oligoadenylate synthetase 1. (400 aa)
TRA2BTransformer 2 beta homolog. (288 aa)
CNR2Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)
BHLHA15Basic helix-loop-helix family member a15. (191 aa)
ABCC8ATP binding cassette subfamily C member 8. (1582 aa)
SESN3Sestrin 3. (530 aa)
KLF7Kruppel like factor 7. (302 aa)
SLC12A7Solute carrier family 12 member 7. (940 aa)
AGERAdvanced glycosylation end-product specific receptor. (403 aa)
ENSMLEP00000000301ANK_REP_REGION domain-containing protein. (297 aa)
CPB2Carboxypeptidase B2. (423 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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