(20 nodes) Endoplasmic reticulum quality control compartment network (Mandrillus leucophaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SYVN1	Synoviolin 1. (617 aa)
	UGGT1	UDP-glucose glycoprotein glucosyltransferase 1. (1569 aa)
	MAN1B1	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (699 aa)
	TRIM13	Tripartite motif containing 13. (409 aa)
	RNF103	Ring finger protein 103. (685 aa)
	DERL1	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa)
	ENSMLEP00000006599	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa)
	EDEM3	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (932 aa)
	EDEM2	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (578 aa)
	EDEM1	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (376 aa)
	ENSMLEP00000015917	Glyco_transf_24 domain-containing protein. (85 aa)
	LOC105532484	Uncharacterized protein. (361 aa)
	RHBDD1	Rhomboid domain containing 1. (316 aa)
	RNF5	Ring finger protein 5. (180 aa)
	FBXO6	F-box protein 6. (293 aa)
	ERN2	Endoplasmic reticulum to nucleus signaling 2. (821 aa)
	SEC61B	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa)
	AMFR	Autocrine motility factor receptor. (558 aa)
	CALR	Calreticulin. (417 aa)
	ASGR2	Asialoglycoprotein receptor 2. (311 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMFR	DERL1	ENSMLEP00000037875	ENSMLEP00000006006	Autocrine motility factor receptor.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.986
AMFR	ERN2	ENSMLEP00000037875	ENSMLEP00000032861	Autocrine motility factor receptor.	Endoplasmic reticulum to nucleus signaling 2.	0.664
AMFR	RNF103	ENSMLEP00000037875	ENSMLEP00000004085	Autocrine motility factor receptor.	Ring finger protein 103.	0.591
AMFR	RNF5	ENSMLEP00000037875	ENSMLEP00000026605	Autocrine motility factor receptor.	Ring finger protein 5.	0.618
AMFR	SYVN1	ENSMLEP00000037875	ENSMLEP00000039648	Autocrine motility factor receptor.	Synoviolin 1.	0.531
CALR	EDEM1	ENSMLEP00000037878	ENSMLEP00000014786	Calreticulin.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.491
CALR	UGGT1	ENSMLEP00000037878	ENSMLEP00000001700	Calreticulin.	UDP-glucose glycoprotein glucosyltransferase 1.	0.407
DERL1	AMFR	ENSMLEP00000006006	ENSMLEP00000037875	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Autocrine motility factor receptor.	0.986
DERL1	EDEM1	ENSMLEP00000006006	ENSMLEP00000014786	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.545
DERL1	EDEM2	ENSMLEP00000006006	ENSMLEP00000009086	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.411
DERL1	EDEM3	ENSMLEP00000006006	ENSMLEP00000008421	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.575
DERL1	RNF5	ENSMLEP00000006006	ENSMLEP00000026605	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Ring finger protein 5.	0.821
DERL1	SYVN1	ENSMLEP00000006006	ENSMLEP00000039648	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Synoviolin 1.	0.982
EDEM1	CALR	ENSMLEP00000014786	ENSMLEP00000037878	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	Calreticulin.	0.491
EDEM1	DERL1	ENSMLEP00000014786	ENSMLEP00000006006	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.545
EDEM1	EDEM2	ENSMLEP00000014786	ENSMLEP00000009086	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.894
EDEM1	EDEM3	ENSMLEP00000014786	ENSMLEP00000008421	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.918
EDEM2	DERL1	ENSMLEP00000009086	ENSMLEP00000006006	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.411
EDEM2	EDEM1	ENSMLEP00000009086	ENSMLEP00000014786	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.894
EDEM2	EDEM3	ENSMLEP00000009086	ENSMLEP00000008421	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.916