STRINGSTRING
ENSMLEP00000005586 ENSMLEP00000005586 FURIN FURIN ARIH2 ARIH2 ZYG11A ZYG11A RBX1 RBX1 DDB1 DDB1 BAG6 BAG6 PCSK9 PCSK9 SIRT2 SIRT2 ENSMLEP00000038668 ENSMLEP00000038668 USP5 USP5 TNFRSF1B TNFRSF1B FBXO22 FBXO22 TIPARP TIPARP SGTA SGTA PACSIN3 PACSIN3 SH3D19 SH3D19 RNF180 RNF180 DAB2 DAB2 NFE2L2 NFE2L2 PRKN PRKN STX5 STX5 ZNF268 ZNF268 ZER1 ZER1 PIAS1 PIAS1 ENSMLEP00000036399 ENSMLEP00000036399 FZR1 FZR1 NUPR1 NUPR1 RNF14 RNF14 ARIH1 ARIH1 TRIB3 TRIB3 RNF19B RNF19B RCHY1 RCHY1 CBLB CBLB GCLC GCLC DDRGK1 DDRGK1 BAG2 BAG2 GPLD1 GPLD1 ENSMLEP00000033784 ENSMLEP00000033784 PLK3 PLK3 APC APC IDE IDE PRICKLE1 PRICKLE1 DACT1 DACT1 COP1 COP1 C4BPB C4BPB GGA3 GGA3 OSBPL7 OSBPL7 RAB7A RAB7A PSMC2 PSMC2 VIP VIP LRP1 LRP1 ASB9 ASB9 VGLL4 VGLL4 SH3RF2 SH3RF2 PSMC6 PSMC6 SORL1 SORL1 RHBDD3 RHBDD3 XBP1 XBP1 ENSMLEP00000030622 ENSMLEP00000030622 SGSM3 SGSM3 HSPBP1 HSPBP1 RNFT1 RNFT1 RNF41 RNF41 SMAD7 SMAD7 ANKIB1 ANKIB1 ENSMLEP00000029005 ENSMLEP00000029005 CDC20B CDC20B TREM2 TREM2 RGMA RGMA GABARAP GABARAP ENSMLEP00000028226 ENSMLEP00000028226 ADAM8 ADAM8 ASB5 ASB5 WNT5A WNT5A AKT1 AKT1 LOC105529698 LOC105529698 PSMC4 PSMC4 CDC20 CDC20 EGLN2 EGLN2 CSNK2A1 CSNK2A1 PSMC1 PSMC1 IL33 IL33 GGA1 GGA1 LOC105538880 LOC105538880 SNF8 SNF8 STUB1 STUB1 HECTD1 HECTD1 VPS11 VPS11 GPC3 GPC3 FBXW9 FBXW9 MSN MSN AMER1 AMER1 NKD2 NKD2 ATXN3 ATXN3 LOC105552274 LOC105552274 IL1B IL1B RNF144A RNF144A GSK3B GSK3B APC2 APC2 ENSMLEP00000024469 ENSMLEP00000024469 TRIB2 TRIB2 FMR1 FMR1 TNFSF12 TNFSF12 SNX9 SNX9 VCP VCP RHBDD1 RHBDD1 FBXL5 FBXL5 PLK1 PLK1 ENSMLEP00000022706 ENSMLEP00000022706 ITCH ITCH FBXW7 FBXW7 OAZ3 OAZ3 IFNG IFNG OAZ2 OAZ2 LOC105536463 LOC105536463 CLU CLU DET1 DET1 TAF1 TAF1 ENSMLEP00000021441 ENSMLEP00000021441 SUMO1 SUMO1 HERPUD1 HERPUD1 ENSMLEP00000019789 ENSMLEP00000019789 PSEN1 PSEN1 RILP RILP RNF19A RNF19A TMTC3 TMTC3 DTL DTL RACK1 RACK1 USP13 USP13 PSMC3 PSMC3 NEDD4 NEDD4 ECSCR ECSCR ENSMLEP00000016698 ENSMLEP00000016698 NOP53 NOP53 NKD1 NKD1 ENSMLEP00000016378 ENSMLEP00000016378 PSMD10 PSMD10 AXIN1 AXIN1 ENSMLEP00000015948 ENSMLEP00000015948 ENSMLEP00000015845 ENSMLEP00000015845 BBS7 BBS7 LRRK2 LRRK2 ENSMLEP00000015404 ENSMLEP00000015404 ENSMLEP00000015186 ENSMLEP00000015186 ENSMLEP00000015075 ENSMLEP00000015075 SEC22B SEC22B BARD1 BARD1 OAZ1 OAZ1 SIRT6 SIRT6 ENSMLEP00000013987 ENSMLEP00000013987 C4BPA C4BPA HAMP HAMP RNFT2 RNFT2 CSNK1D CSNK1D DAB2IP DAB2IP LOC105537007 LOC105537007 LDLR LDLR ZYG11B ZYG11B NDFIP1 NDFIP1 ADAM9 ADAM9 CBFA2T3 CBFA2T3 CUL4B CUL4B LRP2 LRP2 CDKN1B CDKN1B FBXW8 FBXW8 CAV1 CAV1 RNF185 RNF185 AXIN2 AXIN2 ENSMLEP00000008857 ENSMLEP00000008857 VPS35 VPS35 ENSMLEP00000008466 ENSMLEP00000008466 LOC105534357 LOC105534357 FAF1 FAF1 MYLIP MYLIP LOC105546533 LOC105546533 DVL1 DVL1 MAPK9 MAPK9 UBQLN2 UBQLN2 SOCS5 SOCS5 EZR EZR ATG7 ATG7 NDUFA13 NDUFA13 ENSMLEP00000006413 ENSMLEP00000006413 TRIM32 TRIM32 ENSMLEP00000006383 ENSMLEP00000006383 SNX33 SNX33 RAD23A RAD23A RNF144B RNF144B TNFAIP3 TNFAIP3 CLUL1 CLUL1 PSMC5 PSMC5 TAF1L TAF1L DNAJB2 DNAJB2 ENSMLEP00000003274 ENSMLEP00000003274 ENSMLEP00000002739 ENSMLEP00000002739 MKRN2 MKRN2 SH3RF3 SH3RF3 KLHL40 KLHL40 AURKA AURKA TRIB1 TRIB1 SOCS4 SOCS4 CREBRF CREBRF PLK2 PLK2 NUB1 NUB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSMLEP00000005586ATPase_AAA_core domain-containing protein; Belongs to the AAA ATPase family. (179 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
ARIH2RBR-type E3 ubiquitin transferase. (471 aa)
ZYG11AZyg-11 family member A, cell cycle regulator. (671 aa)
RBX1RING-type domain-containing protein. (108 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
BAG6BCL2 associated athanogene 6. (1162 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9. (692 aa)
SIRT2Sirtuin 2. (528 aa)
ENSMLEP00000038668Prot_ATP_ID_OB domain-containing protein. (166 aa)
USP5Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (858 aa)
TNFRSF1BTNF receptor superfamily member 1B. (462 aa)
FBXO22F-box protein 22. (404 aa)
TIPARPTCDD inducible poly(ADP-ribose) polymerase. (657 aa)
SGTASmall glutamine rich tetratricopeptide repeat containing alpha. (313 aa)
PACSIN3Protein kinase C and casein kinase substrate in neurons 3. (424 aa)
SH3D19SH3 domain containing 19. (1008 aa)
RNF180Uncharacterized protein. (416 aa)
DAB2DAB adaptor protein 2. (770 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (596 aa)
PRKNUbiquitin-like domain-containing protein. (368 aa)
STX5Syntaxin 5; Belongs to the syntaxin family. (361 aa)
ZNF268Zinc finger protein 268. (947 aa)
ZER1Zyg-11 related cell cycle regulator. (766 aa)
PIAS1Protein inhibitor of activated STAT 1. (653 aa)
ENSMLEP00000036399Uncharacterized protein. (95 aa)
FZR1Fizzy and cell division cycle 20 related 1. (522 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (100 aa)
RNF14RBR-type E3 ubiquitin transferase. (474 aa)
ARIH1RBR-type E3 ubiquitin transferase. (407 aa)
TRIB3Tribbles pseudokinase 3. (385 aa)
RNF19BRBR-type E3 ubiquitin transferase. (541 aa)
RCHY1Ring finger and CHY zinc finger domain containing 1. (261 aa)
CBLBCbl proto-oncogene B. (982 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (587 aa)
DDRGK1DDRGK domain containing 1. (314 aa)
BAG2BCL2 associated athanogene 2. (175 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (794 aa)
ENSMLEP00000033784Sox C-terminal domain-containing protein. (99 aa)
PLK3Serine/threonine-protein kinase PLK. (626 aa)
APCAPC regulator of WNT signaling pathway. (2806 aa)
IDEInsulin degrading enzyme; Belongs to the peptidase M16 family. (1019 aa)
PRICKLE1Prickle planar cell polarity protein 1. (831 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (753 aa)
COP1COP1 E3 ubiquitin ligase. (731 aa)
C4BPBComplement component 4 binding protein beta. (252 aa)
GGA3Golgi associated, gamma adaptin ear containing, ARF binding protein 3. (723 aa)
OSBPL7Oxysterol-binding protein; Belongs to the OSBP family. (842 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (467 aa)
VIPVasoactive intestinal peptide. (170 aa)
LRP1LDL receptor related protein 1. (4546 aa)
ASB9Ankyrin repeat and SOCS box containing 9. (262 aa)
VGLL4Vestigial like family member 4. (296 aa)
SH3RF2SH3 domain containing ring finger 2. (729 aa)
PSMC6AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)
SORL1Sortilin related receptor 1. (2218 aa)
RHBDD3Rhomboid domain containing 3. (386 aa)
XBP1X-box binding protein 1. (204 aa)
ENSMLEP00000030622Small ubiquitin-related modifier. (81 aa)
SGSM3Small G protein signaling modulator 3. (750 aa)
HSPBP1HSPA (Hsp70) binding protein 1. (342 aa)
RNFT1Ring finger protein, transmembrane 1. (401 aa)
RNF41Ring finger protein 41. (317 aa)
SMAD7MH2 domain-containing protein. (211 aa)
ANKIB1RBR-type E3 ubiquitin transferase. (826 aa)
ENSMLEP00000029005ATG7_N domain-containing protein. (78 aa)
CDC20BCell division cycle 20B. (477 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (231 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (458 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
ENSMLEP00000028226RBR-type E3 ubiquitin transferase. (391 aa)
ADAM8ADAM metallopeptidase domain 8. (715 aa)
ASB5Ankyrin repeat and SOCS box containing 5. (322 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
LOC105529698Uncharacterized protein. (597 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
CDC20Cell division cycle 20. (499 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (405 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
IL33Interleukin 33. (270 aa)
GGA1Golgi associated, gamma adaptin ear containing, ARF binding protein 1. (639 aa)
LOC105538880Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
SNF8Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
STUB1STIP1 homology and U-box containing protein 1. (250 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
VPS11Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (941 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (603 aa)
FBXW9F-box and WD repeat domain containing 9. (458 aa)
MSNMoesin. (581 aa)
AMER1APC membrane recruitment protein 1. (803 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (407 aa)
ATXN3Ataxin 3. (340 aa)
LOC105552274Uncharacterized protein. (906 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
RNF144ARBR-type E3 ubiquitin transferase. (249 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
APC2APC regulator of WNT signaling pathway 2. (1668 aa)
ENSMLEP00000024469Uncharacterized protein. (284 aa)
TRIB2Tribbles pseudokinase 2. (343 aa)
FMR1Fragile X mental retardation 1. (632 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (249 aa)
SNX9Sorting nexin. (596 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
RHBDD1Rhomboid domain containing 1. (316 aa)
FBXL5F-box and leucine rich repeat protein 5. (673 aa)
PLK1Serine/threonine-protein kinase PLK. (603 aa)
ENSMLEP00000022706Zf-rbx1 domain-containing protein. (93 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
OAZ3Ornithine decarboxylase antizyme 3. (235 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
OAZ2Ornithine decarboxylase antizyme 2. (189 aa)
LOC105536463AAA domain-containing protein; Belongs to the AAA ATPase family. (366 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa)
DET1Uncharacterized protein. (562 aa)
TAF1Transcription initiation factor TFIID subunit. (1881 aa)
ENSMLEP00000021441FERM domain-containing protein. (478 aa)
SUMO1Ubiquitin-like domain-containing protein. (62 aa)
HERPUD1Homocysteine inducible ER protein with ubiquitin like domain 1. (391 aa)
ENSMLEP00000019789ANK_REP_REGION domain-containing protein. (165 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
RILPRab interacting lysosomal protein. (253 aa)
RNF19ARBR-type E3 ubiquitin transferase. (838 aa)
TMTC3Transmembrane O-mannosyltransferase targeting cadherins 3. (914 aa)
DTLDenticleless E3 ubiquitin protein ligase homolog. (730 aa)
RACK1Receptor for activated C kinase 1. (318 aa)
USP13Ubiquitin specific peptidase 13; Belongs to the peptidase C19 family. (458 aa)
PSMC3AAA domain-containing protein; Belongs to the AAA ATPase family. (446 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1272 aa)
ECSCRUncharacterized protein. (205 aa)
ENSMLEP00000016698AAA domain-containing protein; Belongs to the AAA ATPase family. (390 aa)
NOP53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (466 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (501 aa)
ENSMLEP00000016378AAA domain-containing protein. (201 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
AXIN1Axin 1. (859 aa)
ENSMLEP00000015948Uncharacterized protein. (90 aa)
ENSMLEP00000015845Rad60-SLD domain-containing protein. (78 aa)
BBS7Bardet-Biedl syndrome 7. (503 aa)
LRRK2Leucine rich repeat kinase 2. (2182 aa)
ENSMLEP00000015404Fork-head domain-containing protein. (531 aa)
ENSMLEP00000015186Uncharacterized protein. (338 aa)
ENSMLEP00000015075RBR-type E3 ubiquitin transferase. (290 aa)
SEC22BSEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (215 aa)
BARD1BRCA1 associated RING domain 1. (759 aa)
OAZ1Ornithine decarboxylase antizyme 1. (195 aa)
SIRT6Sirtuin 6. (355 aa)
ENSMLEP00000013987Uncharacterized protein. (60 aa)
C4BPAComplement component 4 binding protein alpha. (597 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
RNFT2Ring finger protein, transmembrane 2. (435 aa)
CSNK1DCasein kinase 1 delta. (434 aa)
DAB2IPDAB2 interacting protein. (1153 aa)
LOC105537007Ubiquitin-like domain-containing protein. (103 aa)
LDLRLow density lipoprotein receptor. (860 aa)
ZYG11BZyg-11 family member B, cell cycle regulator. (761 aa)
NDFIP1Nedd4 family interacting protein 1. (200 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
CBFA2T3CBFA2/RUNX1 partner transcriptional co-repressor 3. (589 aa)
CUL4BCullin 4B; Belongs to the cullin family. (931 aa)
LRP2LDL receptor related protein 2. (4655 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
FBXW8F-box and WD repeat domain containing 8. (492 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
RNF185Ring finger protein 185. (195 aa)
AXIN2Axin 2. (843 aa)
ENSMLEP00000008857Uncharacterized protein. (263 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (664 aa)
ENSMLEP00000008466Josephin domain-containing protein. (133 aa)
LOC105534357RBR-type E3 ubiquitin transferase. (77 aa)
FAF1Fas associated factor 1. (490 aa)
MYLIPMyosin regulatory light chain interacting protein. (445 aa)
LOC105546533ANK_REP_REGION domain-containing protein. (271 aa)
DVL1Dishevelled segment polarity protein 1. (591 aa)
MAPK9Mitogen-activated protein kinase. (395 aa)
UBQLN2Ubiquilin 2. (624 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
EZREzrin. (588 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (704 aa)
NDUFA13NADH:ubiquinone oxidoreductase subunit A13. (163 aa)
ENSMLEP00000006413AAA domain-containing protein; Belongs to the AAA ATPase family. (423 aa)
TRIM32Tripartite motif containing 32. (653 aa)
ENSMLEP00000006383Uncharacterized protein. (234 aa)
SNX33Sorting nexin. (574 aa)
RAD23ARAD23 homolog A, nucleotide excision repair protein. (363 aa)
RNF144BRBR-type E3 ubiquitin transferase. (303 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
CLUL1Clusterin; Belongs to the clusterin family. (506 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
TAF1LTranscription initiation factor TFIID subunit. (1884 aa)
DNAJB2DnaJ heat shock protein family (Hsp40) member B2. (324 aa)
ENSMLEP00000003274Uncharacterized protein. (105 aa)
ENSMLEP00000002739RBR-type E3 ubiquitin transferase. (273 aa)
MKRN2Makorin ring finger protein 2. (405 aa)
SH3RF3SH3 domain containing ring finger 3. (731 aa)
KLHL40Kelch like family member 40. (621 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (384 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
CREBRFCREB3 regulatory factor. (639 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
NUB1Negative regulator of ubiquitin like proteins 1. (610 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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