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SLC45A3 SLC45A3 IRS1 IRS1 ACTN3 ACTN3 HTR2A HTR2A P2RY1 P2RY1 EGF EGF IGF1 IGF1 P2RY6 P2RY6 MTOR MTOR SIRT1 SIRT1 EPM2AIP1 EPM2AIP1 ADCYAP1R1 ADCYAP1R1 MAS1 MAS1 HAS2 HAS2 PRKAA2 PRKAA2 CD244 CD244 LHCGR LHCGR IGF2 IGF2 ENSMLEP00000040511 ENSMLEP00000040511 DDB1 DDB1 SLC4A4 SLC4A4 ARNT ARNT P2RX7 P2RX7 DGAT2 DGAT2 GPER1 GPER1 SRC SRC PRKAA1 PRKAA1 GPLD1 GPLD1 GPD1 GPD1 PHKG2 PHKG2 NNMT NNMT AVPR1B AVPR1B RPTOR RPTOR APP APP PDGFB PDGFB GCK GCK MLST8 MLST8 PTPN2 PTPN2 MLXIPL MLXIPL KAT2A KAT2A GPT GPT AKT1 AKT1 PRXL2C PRXL2C STK11 STK11 ARPP19 ARPP19 SORBS1 SORBS1 NTSR1 NTSR1 DYRK2 DYRK2 PTH PTH LOC105533626 LOC105533626 GCG GCG AKT2 AKT2 PPARA PPARA ENSMLEP00000020744 ENSMLEP00000020744 PPARGC1A PPARGC1A PSEN1 PSEN1 ZBTB20 ZBTB20 INSR INSR HIF1A HIF1A WDR5 WDR5 PRKCE PRKCE ENSMLEP00000015404 ENSMLEP00000015404 KAT2B KAT2B NFKB1 NFKB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC45A3Solute carrier family 45 member 3. (553 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (916 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1152 aa)
IGF1Insulin like growth factor 1. (159 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
SIRT1Sirtuin 1. (661 aa)
EPM2AIP1EPM2A interacting protein 1. (607 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (523 aa)
MAS1MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (325 aa)
HAS2Hyaluronan synthase 2. (552 aa)
PRKAA2Non-specific serine/threonine protein kinase. (542 aa)
CD244CD244 molecule. (370 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (657 aa)
IGF2Insulin like growth factor 2. (236 aa)
ENSMLEP00000040511Uncharacterized protein. (645 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
SLC4A4Anion exchange protein. (1100 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (734 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
DGAT2Diacylglycerol O-acyltransferase 2. (388 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (400 aa)
SRCTyrosine-protein kinase. (542 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (794 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (410 aa)
NNMTNicotinamide N-methyltransferase. (264 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (424 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1291 aa)
APPAmyloid beta precursor protein. (772 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
GCKPhosphotransferase. (466 aa)
MLST8MTOR associated protein, LST8 homolog. (335 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (403 aa)
MLXIPLMLX interacting protein like. (784 aa)
KAT2ALysine acetyltransferase 2A. (755 aa)
GPTGlutamic--pyruvic transaminase. (496 aa)
AKT1Non-specific serine/threonine protein kinase. (432 aa)
PRXL2CUncharacterized protein. (232 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
ARPP19cAMP regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (116 aa)
SORBS1Sorbin and SH3 domain containing 1. (1294 aa)
NTSR1Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (401 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (604 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
LOC105533626Uncharacterized protein. (220 aa)
GCGGlucagon. (180 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PPARAPeroxisome proliferator activated receptor alpha. (365 aa)
ENSMLEP00000020744Uncharacterized protein. (107 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
ZBTB20Zinc finger and BTB domain containing 20. (741 aa)
INSRTyrosine-protein kinase receptor. (1301 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (758 aa)
WDR5WD repeat domain 5. (334 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
ENSMLEP00000015404Fork-head domain-containing protein. (531 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (778 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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