(51 nodes) Synaptic vesicle endocytosis network (Mandrillus leucophaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NLGN1	Neuroligin 1. (823 aa)
	STON1	Stonin-1; May be involved in the endocytic machinery. (735 aa)
	SYT8	Synaptotagmin 8. (387 aa)
	SYNPR	Synaptoporin. (245 aa)
	SNCG	Uncharacterized protein; Belongs to the synuclein family. (124 aa)
	DNM3	Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
	PACSIN1	Protein kinase C and casein kinase substrate in neurons 1. (444 aa)
	ARF6	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
	SYT5	Synaptotagmin 5. (386 aa)
	SH3GL1	SH3 domain containing GRB2 like 1, endophilin A2. (367 aa)
	SYNJ2	Synaptojanin 2. (1456 aa)
	SH3GL3	SH3 domain containing GRB2 like 3, endophilin A3. (306 aa)
	SYT2	Synaptotagmin 2. (419 aa)
	AP3D1	AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (1181 aa)
	BIN1	Bridging integrator 1. (593 aa)
	SNCB	Beta-synuclein; Belongs to the synuclein family. (134 aa)
	OPHN1	Oligophrenin 1. (775 aa)
	DNAJC6	DnaJ heat shock protein family (Hsp40) member C6. (942 aa)
	NOSTRIN	Nitric oxide synthase trafficking. (536 aa)
	PIP5K1C	Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (669 aa)
	DNM2	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (810 aa)
	RAB27B	RAB27B, member RAS oncogene family. (218 aa)
	AP3S1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (170 aa)
	DNM1	Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (797 aa)
	NLGN3	Neuroligin 3. (848 aa)
	AP3B2	AP-3 complex subunit beta. (1065 aa)
	ITSN2	Intersectin 2. (1697 aa)
	ITSN1	Intersectin 1. (1719 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (302 aa)
	SH3GL2	SH3 domain containing GRB2 like 2, endophilin A1. (357 aa)
	AP3M2	AP-3 complex subunit mu-2. (418 aa)
	NLGN2	Neuroligin 2. (834 aa)
	BTBD8	BTB domain containing 8. (1411 aa)
	ENSMLEP00000025432	B2-adapt-app_C domain-containing protein. (224 aa)
	AMPH	Amphiphysin. (677 aa)
	SYNJ1	Synaptojanin 1. (1614 aa)
	PICALM	Phosphatidylinositol binding clathrin assembly protein. (674 aa)
	ACTB	Actin beta. (375 aa)
	SNAP91	Synaptosome associated protein 91. (872 aa)
	LRRC1	Leucine rich repeat containing 1. (507 aa)
	STON2	Stonin-2; Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating; Belongs to the Stoned B family. (920 aa)
	CANX	Calnexin. (592 aa)
	STX1A	Syntaxin 1A; Belongs to the syntaxin family. (288 aa)
	SYP	Synaptophysin. (313 aa)
	VAMP1	Vesicle associated membrane protein 1. (118 aa)
	KIAA1109	KIAA1109. (5005 aa)
	AP2B1	AP complex subunit beta. (942 aa)
	FCHO2	FCH domain only 2. (815 aa)
	SCRIB	Scribble planar cell polarity protein. (1445 aa)
	DENND1A	DENN domain containing 1A. (1007 aa)
	GAK	Cyclin G associated kinase. (1311 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ITSN1	ENSMLEP00000029448	ENSMLEP00000019264	Actin beta.	Intersectin 1.	0.568
ACTB	ITSN2	ENSMLEP00000029448	ENSMLEP00000019044	Actin beta.	Intersectin 2.	0.872
ACTB	PIP5K1C	ENSMLEP00000029448	ENSMLEP00000014692	Actin beta.	Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma.	0.880
AMPH	AP2B1	ENSMLEP00000025858	ENSMLEP00000036489	Amphiphysin.	AP complex subunit beta.	0.701
AMPH	BIN1	ENSMLEP00000025858	ENSMLEP00000011424	Amphiphysin.	Bridging integrator 1.	0.972
AMPH	DNM1	ENSMLEP00000025858	ENSMLEP00000017210	Amphiphysin.	Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.966
AMPH	DNM2	ENSMLEP00000025858	ENSMLEP00000015375	Amphiphysin.	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.950
AMPH	DNM3	ENSMLEP00000025858	ENSMLEP00000002559	Amphiphysin.	Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.602
AMPH	ENSMLEP00000025432	ENSMLEP00000025858	ENSMLEP00000025432	Amphiphysin.	B2-adapt-app_C domain-containing protein.	0.701
AMPH	FCHO2	ENSMLEP00000025858	ENSMLEP00000036641	Amphiphysin.	FCH domain only 2.	0.571
AMPH	ITSN1	ENSMLEP00000025858	ENSMLEP00000019264	Amphiphysin.	Intersectin 1.	0.511
AMPH	ITSN2	ENSMLEP00000025858	ENSMLEP00000019044	Amphiphysin.	Intersectin 2.	0.514
AMPH	SH3GL2	ENSMLEP00000025858	ENSMLEP00000019823	Amphiphysin.	SH3 domain containing GRB2 like 2, endophilin A1.	0.570
AMPH	SNAP91	ENSMLEP00000025858	ENSMLEP00000029456	Amphiphysin.	Synaptosome associated protein 91.	0.415
AMPH	SYNJ1	ENSMLEP00000025858	ENSMLEP00000026181	Amphiphysin.	Synaptojanin 1.	0.567
AMPH	SYNJ2	ENSMLEP00000025858	ENSMLEP00000005823	Amphiphysin.	Synaptojanin 2.	0.534
AP2B1	AMPH	ENSMLEP00000036489	ENSMLEP00000025858	AP complex subunit beta.	Amphiphysin.	0.701
AP2B1	AP3B2	ENSMLEP00000036489	ENSMLEP00000018259	AP complex subunit beta.	AP-3 complex subunit beta.	0.677
AP2B1	AP3D1	ENSMLEP00000036489	ENSMLEP00000010235	AP complex subunit beta.	AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.	0.862
AP2B1	AP3M2	ENSMLEP00000036489	ENSMLEP00000023006	AP complex subunit beta.	AP-3 complex subunit mu-2.	0.409