STRINGSTRING
NRP2 NRP2 SEMA3A SEMA3A HMGA2 HMGA2 SIX2 SIX2 SEMA6B SEMA6B CYP26C1 CYP26C1 BMP4 BMP4 NRP1 NRP1 RADIL RADIL RDH10 RDH10 SOX9 SOX9 OLFM1 OLFM1 S100A4 S100A4 POLR1B POLR1B SEMA7A SEMA7A EDN3 EDN3 ALX1 ALX1 EDNRB EDNRB RET RET FAM83D FAM83D SFRP1 SFRP1 SEMA3F SEMA3F LOC105555235 LOC105555235 EDNRA EDNRA ENSMLEP00000015894 ENSMLEP00000015894 SEMA3D SEMA3D GDNF GDNF SEMA3C SEMA3C EPB41L5 EPB41L5 HIF1A HIF1A LOXL2 LOXL2 TRIM28 TRIM28 HEYL HEYL SEMA4G SEMA4G AKNA AKNA LOXL3 LOXL3 SEMA4A SEMA4A NOTCH4-2 NOTCH4-2 ENSMLEP00000019231 ENSMLEP00000019231 SNAI2 SNAI2 NOTCH1 NOTCH1 NRG1 NRG1 ENSMLEP00000020910 ENSMLEP00000020910 MAPK3 MAPK3 BMPR1A BMPR1A TGFBR1 TGFBR1 JAG1 JAG1 MEF2C MEF2C HAND2 HAND2 HGF HGF TCOF1 TCOF1 ANXA6 ANXA6 EOMES EOMES WWTR1 WWTR1 MAPK1 MAPK1 FAM172A FAM172A ENSMLEP00000024077 ENSMLEP00000024077 ZFP64 ZFP64 OSR1 OSR1 LAMA5 LAMA5 FOXC2 FOXC2 GSK3B GSK3B FRZB FRZB OVOL2 OVOL2 TCF21 TCF21 AMER1 AMER1 RPS7 RPS7 SEMA4D SEMA4D EXT1 EXT1 ACVR1 ACVR1 SEMA5B SEMA5B FN1 FN1 FLNA FLNA WNT5A WNT5A PPP3R1 PPP3R1 RFLNB RFLNB SEMA4F SEMA4F FGF8 FGF8 SOX8 SOX8 PAX2 PAX2 SOX10 SOX10 STAT1 STAT1 SNAI1 SNAI1 PDCD6 PDCD6 WNT10A WNT10A SEMA4C SEMA4C SEMA3G SEMA3G WNT16 WNT16 NOLC1 NOLC1 SEMA5A SEMA5A EFNA1 EFNA1 OTUD5 OTUD5 KBTBD8 KBTBD8 SEMA3E SEMA3E ENSMLEP00000034447 ENSMLEP00000034447 DDX5 DDX5 BMP7 BMP7 SEMA4B SEMA4B FGF19 FGF19 TGFB2 TGFB2 ENSMLEP00000037023 ENSMLEP00000037023 RTN4 RTN4 ROCK1 ROCK1 LOC105543876 LOC105543876 TGFBR3 TGFBR3 DACT3 DACT3 SEMA6A SEMA6A CORO1C CORO1C PWWP2A PWWP2A TASOR TASOR LOC105538609 LOC105538609 TBX3 TBX3 BMP2 BMP2 WNT11 WNT11 HEY1 HEY1 TGFB1 TGFB1 TBX20 TBX20 SMO SMO TMEM100 TMEM100 EDN1 EDN1 LRP6 LRP6 HAS2 HAS2 SPRY1 SPRY1 TAPT1 TAPT1 KLHL12 KLHL12 HTR2B HTR2B RANBP3L RANBP3L ERBB4 ERBB4 BCL2 BCL2 ISL1 ISL1 LEF1 LEF1 KITLG KITLG PEF1 PEF1 FGFR2 FGFR2 NOG NOG CUL7 CUL7 SMAD4 SMAD4 ENG ENG HEY2 HEY2 DLG5 DLG5 NOTCH4 NOTCH4 CTNNB1 CTNNB1 SEMA3B SEMA3B WNT8A WNT8A FGF10 FGF10 ROCK2 ROCK2 PITX2 PITX2 DDX17 DDX17 EFNB1 EFNB1 ADAM15 ADAM15 WNT4 WNT4 CITED2 CITED2 WNT2 WNT2 FGFR1 FGFR1 LOC105528799 LOC105528799 CDH2 CDH2 ENSMLEP00000011966 ENSMLEP00000011966 PHACTR4 PHACTR4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NRP2Neuropilin; Belongs to the neuropilin family. (930 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (740 aa)
HMGA2High mobility group AT-hook 2. (109 aa)
SIX2SIX homeobox 2. (290 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (588 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (515 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
RADILRap associating with DIL domain. (1059 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (284 aa)
SOX9SRY-box transcription factor 9. (428 aa)
OLFM1Olfactomedin 1. (455 aa)
S100A4Protein S100; Belongs to the S-100 family. (101 aa)
POLR1BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1079 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (637 aa)
EDN3Endothelin 3. (211 aa)
ALX1ALX homeobox 1. (326 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (507 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1107 aa)
FAM83DFamily with sequence similarity 83 member D. (500 aa)
SFRP1Secreted frizzled related protein 1. (206 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (785 aa)
LOC10555523540S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (179 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
ENSMLEP00000015894Uncharacterized protein. (323 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (777 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (718 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (758 aa)
LOXL2Lysyl oxidase like 2. (774 aa)
TRIM28Tripartite motif containing 28. (738 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (844 aa)
AKNAAT-hook transcription factor. (1437 aa)
LOXL3Lysyl oxidase like 3. (753 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (760 aa)
NOTCH4-2Notch receptor 4. (159 aa)
ENSMLEP00000019231Sema domain-containing protein; Belongs to the semaphorin family. (513 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
NOTCH1Notch receptor 1. (2076 aa)
NRG1Neuregulin 1. (713 aa)
ENSMLEP0000002091040S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (159 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1214 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
HAND2Uncharacterized protein. (66 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
TCOF1Treacle ribosome biogenesis factor 1. (1485 aa)
ANXA6Annexin. (676 aa)
EOMESEomesodermin. (705 aa)
WWTR1WW domain containing transcription regulator 1. (390 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
FAM172AFamily with sequence similarity 172 member A. (416 aa)
ENSMLEP0000002407740S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (202 aa)
ZFP64ZFP64 zinc finger protein. (677 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
LAMA5Laminin subunit alpha 5. (3494 aa)
FOXC2Forkhead box C2. (254 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
FRZBFrizzled related protein. (325 aa)
OVOL2Ovo like zinc finger 2. (258 aa)
TCF21Transcription factor 21. (179 aa)
AMER1APC membrane recruitment protein 1. (803 aa)
RPS740S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (859 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (425 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
SEMA5BSemaphorin 5B. (1035 aa)
FN1Fibronectin 1. (2384 aa)
FLNAFilamin A. (2565 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PPP3R1Uncharacterized protein. (189 aa)
RFLNBRefilin B. (144 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (770 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
SOX8SRY-box transcription factor 8. (379 aa)
PAX2Paired box 2. (407 aa)
SOX10SRY-box transcription factor 10. (420 aa)
STAT1Signal transducer and activator of transcription. (758 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
PDCD6Programmed cell death 6. (121 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (782 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (711 aa)
SEMA5ASemaphorin 5A. (1027 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
OTUD5OTU deubiquitinase 5. (434 aa)
KBTBD8Kelch repeat and BTB domain containing 8. (601 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (744 aa)
ENSMLEP00000034447Homeobox domain-containing protein. (167 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
BMP7TGF_BETA_2 domain-containing protein. (155 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (836 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (308 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ENSMLEP00000037023HH_signal domain-containing protein. (126 aa)
RTN4Reticulon. (1007 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
LOC105543876BTB domain-containing protein. (514 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
DACT3Uncharacterized protein. (181 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (527 aa)
PWWP2APWWP domain containing 2A. (755 aa)
TASORTranscription activation suppressor. (1544 aa)
LOC105538609F-box domain-containing protein. (238 aa)
TBX3T-box transcription factor 3. (743 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (289 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (308 aa)
TGFB1Transforming growth factor beta 1. (226 aa)
TBX20T-box transcription factor 20. (447 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (785 aa)
TMEM100Transmembrane protein 100. (134 aa)
EDN1Endothelin 1. (211 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1595 aa)
HAS2Hyaluronan synthase 2. (552 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
TAPT1Transmembrane anterior posterior transformation 1. (461 aa)
KLHL12BTB domain-containing protein. (568 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
RANBP3LRAN binding protein 3 like. (490 aa)
ERBB4Receptor protein-tyrosine kinase. (1230 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
ISL1ISL LIM homeobox 1. (349 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
PEF1Penta-EF-hand domain containing 1. (283 aa)
FGFR2Fibroblast growth factor receptor. (838 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (221 aa)
CUL7Cullin 7; Belongs to the cullin family. (1697 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ENGEndoglin. (598 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1910 aa)
NOTCH4Notch receptor 4. (2000 aa)
CTNNB1Catenin beta 1. (781 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (749 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1375 aa)
PITX2Homeobox protein. (325 aa)
DDX17DEAD-box helicase 17; Belongs to the DEAD box helicase family. (709 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (346 aa)
ADAM15ADAM metallopeptidase domain 15. (864 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
FGFR1Fibroblast growth factor receptor. (853 aa)
LOC105528799Uncharacterized protein. (199 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (886 aa)
ENSMLEP00000011966Uncharacterized protein. (283 aa)
PHACTR4Phosphatase and actin regulator. (707 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
Server load: medium (48%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.