(51 nodes) Cardiac muscle cell development network (Mandrillus leucophaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FHL2	Four and a half LIM domains 2. (389 aa)
	SORBS2	Sorbin and SH3 domain containing 2. (1200 aa)
	CXADR	CXADR Ig-like cell adhesion molecule. (361 aa)
	AKAP13	A-kinase anchoring protein 13. (2785 aa)
	ASB2	Ankyrin repeat and SOCS box containing 2. (637 aa)
	CSRP3	Cysteine and glycine rich protein 3. (194 aa)
	MYL2	Myosin light chain 2. (166 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (663 aa)
	ALPK2	Alpha kinase 2. (2160 aa)
	TBX5	T-box transcription factor 5. (518 aa)
	BMP10	Bone morphogenetic protein 10. (424 aa)
	TCAP	Titin-cap. (167 aa)
	ALPK3	Alpha kinase 3. (1674 aa)
	GATA4	GATA binding protein 4. (236 aa)
	BVES	Blood vessel epicardial substance. (360 aa)
	NEB	Nebulin. (7453 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
	SGCD	Sarcoglycan delta. (290 aa)
	C10orf113	Chromosome 10 open reading frame 113. (155 aa)
	NRAP	Nebulin related anchoring protein. (1730 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	TBX18	T-box transcription factor 18. (436 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
	OBSL1	Obscurin like 1. (1565 aa)
	LRRC10	Leucine rich repeat containing 10. (279 aa)
	FHOD3	Formin homology 2 domain containing 3. (1498 aa)
	SRF	Serum response factor. (434 aa)
	MYH11	Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1613 aa)
	TBX3	T-box transcription factor 3. (743 aa)
	SHOX2	Short stature homeobox 2. (304 aa)
	SLC8A1	Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
	MYO18B	Myosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2511 aa)
	ADRA1A	Adrenoceptor alpha 1A. (466 aa)
	ENSMLEP00000037519	Uncharacterized protein. (87 aa)
	MEF2A	Myocyte enhancer factor 2A. (513 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (373 aa)
	ADPRHL1	Uncharacterized protein. (1861 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U. (602 aa)
	PDLIM5	PDZ and LIM domain 5. (625 aa)
	NEBL	Nebulette. (1014 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (426 aa)
	ACTN2	Actinin alpha 2. (873 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	SGCB	Sarcoglycan beta. (319 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	MAML1	Mastermind like transcriptional coactivator 1. (926 aa)
	NKX2-5	NK2 homeobox 5. (324 aa)
	PLEC	Plectin. (4048 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN2	CSRP3	ENSMLEP00000026302	ENSMLEP00000015220	Actinin alpha 2.	Cysteine and glycine rich protein 3.	0.772
ACTN2	MYL2	ENSMLEP00000026302	ENSMLEP00000014986	Actinin alpha 2.	Myosin light chain 2.	0.632
ACTN2	NEB	ENSMLEP00000026302	ENSMLEP00000008498	Actinin alpha 2.	Nebulin.	0.567
ACTN2	NEBL	ENSMLEP00000026302	ENSMLEP00000027364	Actinin alpha 2.	Nebulette.	0.506
ACTN2	NRAP	ENSMLEP00000026302	ENSMLEP00000007890	Actinin alpha 2.	Nebulin related anchoring protein.	0.525
ACTN2	OBSL1	ENSMLEP00000026302	ENSMLEP00000004366	Actinin alpha 2.	Obscurin like 1.	0.412
ACTN2	PDLIM5	ENSMLEP00000026302	ENSMLEP00000028240	Actinin alpha 2.	PDZ and LIM domain 5.	0.482
ACTN2	TCAP	ENSMLEP00000026302	ENSMLEP00000011847	Actinin alpha 2.	Titin-cap.	0.751
ALPK3	OBSL1	ENSMLEP00000010108	ENSMLEP00000004366	Alpha kinase 3.	Obscurin like 1.	0.406
ATG5	MTOR	ENSMLEP00000020518	ENSMLEP00000005374	Autophagy protein 5; Involved in autophagic vesicle formation.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.500
BMP10	BMPR1A	ENSMLEP00000011945	ENSMLEP00000021340	Bone morphogenetic protein 10.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.604
BMPR1A	BMP10	ENSMLEP00000021340	ENSMLEP00000011945	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 10.	0.604
CAV3	SGCB	ENSMLEP00000020426	ENSMLEP00000021348	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Sarcoglycan beta.	0.472
CAV3	SGCD	ENSMLEP00000020426	ENSMLEP00000008000	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Sarcoglycan delta.	0.597
CSRP3	ACTN2	ENSMLEP00000015220	ENSMLEP00000026302	Cysteine and glycine rich protein 3.	Actinin alpha 2.	0.772
CSRP3	MYL2	ENSMLEP00000015220	ENSMLEP00000014986	Cysteine and glycine rich protein 3.	Myosin light chain 2.	0.849
CSRP3	NEB	ENSMLEP00000015220	ENSMLEP00000008498	Cysteine and glycine rich protein 3.	Nebulin.	0.428
CSRP3	NRAP	ENSMLEP00000015220	ENSMLEP00000007890	Cysteine and glycine rich protein 3.	Nebulin related anchoring protein.	0.738
CSRP3	TCAP	ENSMLEP00000015220	ENSMLEP00000011847	Cysteine and glycine rich protein 3.	Titin-cap.	0.750
FHL2	GATA4	ENSMLEP00000017945	ENSMLEP00000008648	Four and a half LIM domains 2.	GATA binding protein 4.	0.408