(25 nodes) Cell fate commitment involved in formation of primary germ layer network (Mandrillus leucophaeus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BMP4	Bone morphogenetic protein 4. (408 aa)
	SFRP2	Secreted frizzled related protein 2. (295 aa)
	PAX2	Paired box 2. (407 aa)
	FOXC2	Forkhead box C2. (254 aa)
	HOXA11	Homeobox A11. (311 aa)
	EOMES	Eomesodermin. (705 aa)
	SIX2	SIX homeobox 2. (290 aa)
	EYA2	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (538 aa)
	ETV2	ETS variant 2. (370 aa)
	CDC73	Cell division cycle 73. (531 aa)
	TBX6	T-box transcription factor 6. (436 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	NODAL	Nodal growth differentiation factor. (303 aa)
	ENSMLEP00000013207	Homeobox domain-containing protein. (142 aa)
	PAF1	PAF1 homolog, Paf1/RNA polymerase II complex component. (531 aa)
	ENSMLEP00000033784	Sox C-terminal domain-containing protein. (99 aa)
	KLF4	Uncharacterized protein. (145 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
	HNF1B	HNF1 homeobox B. (557 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	CTR9	CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
	LEO1	LEO1 homolog, Paf1/RNA polymerase II complex component. (666 aa)
	ETS2	Protein C-ets-2; Transcription factor; Belongs to the ETS family. (469 aa)
	RTF1	RTF1 homolog, Paf1/RNA polymerase II complex component. (575 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	ENSMLEP00000033784	ENSMLEP00000039099	ENSMLEP00000033784	Bone morphogenetic protein 4.	Sox C-terminal domain-containing protein.	0.574
BMP4	KLF4	ENSMLEP00000039099	ENSMLEP00000012468	Bone morphogenetic protein 4.	Uncharacterized protein.	0.539
BMP4	SMAD1	ENSMLEP00000039099	ENSMLEP00000019537	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.679
BMP4	WNT3A	ENSMLEP00000039099	ENSMLEP00000019793	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.413
CDC73	CTNNB1	ENSMLEP00000022208	ENSMLEP00000009207	Cell division cycle 73.	Catenin beta 1.	0.823
CDC73	CTR9	ENSMLEP00000022208	ENSMLEP00000006428	Cell division cycle 73.	CTR9 homolog, Paf1/RNA polymerase II complex component.	0.999
CDC73	LEO1	ENSMLEP00000022208	ENSMLEP00000039014	Cell division cycle 73.	LEO1 homolog, Paf1/RNA polymerase II complex component.	0.999
CDC73	PAF1	ENSMLEP00000022208	ENSMLEP00000036710	Cell division cycle 73.	PAF1 homolog, Paf1/RNA polymerase II complex component.	0.998
CDC73	RTF1	ENSMLEP00000022208	ENSMLEP00000003066	Cell division cycle 73.	RTF1 homolog, Paf1/RNA polymerase II complex component.	0.991
CTNNB1	CDC73	ENSMLEP00000009207	ENSMLEP00000022208	Catenin beta 1.	Cell division cycle 73.	0.823
CTNNB1	ENSMLEP00000033784	ENSMLEP00000009207	ENSMLEP00000033784	Catenin beta 1.	Sox C-terminal domain-containing protein.	0.775
CTNNB1	EOMES	ENSMLEP00000009207	ENSMLEP00000023660	Catenin beta 1.	Eomesodermin.	0.517
CTNNB1	KLF4	ENSMLEP00000009207	ENSMLEP00000012468	Catenin beta 1.	Uncharacterized protein.	0.546
CTNNB1	LEO1	ENSMLEP00000009207	ENSMLEP00000039014	Catenin beta 1.	LEO1 homolog, Paf1/RNA polymerase II complex component.	0.955
CTNNB1	SFRP2	ENSMLEP00000009207	ENSMLEP00000030960	Catenin beta 1.	Secreted frizzled related protein 2.	0.558
CTNNB1	SMAD1	ENSMLEP00000009207	ENSMLEP00000019537	Catenin beta 1.	Mothers against decapentaplegic homolog.	0.506
CTNNB1	WNT3A	ENSMLEP00000009207	ENSMLEP00000019793	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.691
CTR9	CDC73	ENSMLEP00000006428	ENSMLEP00000022208	CTR9 homolog, Paf1/RNA polymerase II complex component.	Cell division cycle 73.	0.999
CTR9	LEO1	ENSMLEP00000006428	ENSMLEP00000039014	CTR9 homolog, Paf1/RNA polymerase II complex component.	LEO1 homolog, Paf1/RNA polymerase II complex component.	0.999
CTR9	PAF1	ENSMLEP00000006428	ENSMLEP00000036710	CTR9 homolog, Paf1/RNA polymerase II complex component.	PAF1 homolog, Paf1/RNA polymerase II complex component.	0.998