(36 nodes) Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress network (Mandrillus leucophaeus)

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Your Input:
	ERN2	Endoplasmic reticulum to nucleus signaling 2. (821 aa)
	PML	Promyelocytic leukemia. (858 aa)
	ENSMLEP00000007687	Uncharacterized protein. (91 aa)
	CASP4	Caspase 4; Belongs to the peptidase C14A family. (377 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2731 aa)
	ATP2A3	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (900 aa)
	LOC105538196	Uncharacterized protein. (258 aa)
	ENSMLEP00000011722	Uncharacterized protein. (80 aa)
	DAB2IP	DAB2 interacting protein. (1153 aa)
	QRICH1	Glutamine rich 1. (777 aa)
	CHAC1	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (264 aa)
	ENSMLEP00000015528	Uncharacterized protein. (184 aa)
	PDX1	Pancreatic and duodenal homeobox 1. (283 aa)
	BRSK2	BR serine/threonine kinase 2. (710 aa)
	CASP12	Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (421 aa)
	BAK1	BCL2 antagonist/killer 1. (211 aa)
	ERN1	Endoplasmic reticulum to nucleus signaling 1. (959 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)
	TMEM117	Uncharacterized protein. (136 aa)
	SELENOK	Uncharacterized protein. (93 aa)
	ENSMLEP00000029067	Uncharacterized protein. (101 aa)
	ENSMLEP00000033528	Uncharacterized protein. (75 aa)
	TRIB3	Tribbles pseudokinase 3. (385 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
	PPP1R15A	Protein phosphatase 1 regulatory subunit 15A. (672 aa)
	BAG6	BCL2 associated athanogene 6. (1162 aa)
	MAP3K5	Mitogen-activated protein kinase kinase kinase 5. (1306 aa)
	ATP2A1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1027 aa)
	AIFM1	Apoptosis inducing factor mitochondria associated 1. (613 aa)
	TNFRSF10B	TNF receptor superfamily member 10b. (445 aa)
	ERO1A	Endoplasmic reticulum oxidoreductase 1 alpha. (451 aa)
	BAX	BCL2 associated X, apoptosis regulator. (203 aa)
	DDIT3	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)
	ATF4	Activating transcription factor 4. (351 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIFM1	APAF1	ENSMLEP00000001405	ENSMLEP00000024091	Apoptosis inducing factor mitochondria associated 1.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.483
AIFM1	BAK1	ENSMLEP00000001405	ENSMLEP00000018686	Apoptosis inducing factor mitochondria associated 1.	BCL2 antagonist/killer 1.	0.673
AIFM1	BAX	ENSMLEP00000001405	ENSMLEP00000003786	Apoptosis inducing factor mitochondria associated 1.	BCL2 associated X, apoptosis regulator.	0.993
AIFM1	BCL2	ENSMLEP00000001405	ENSMLEP00000005872	Apoptosis inducing factor mitochondria associated 1.	BCL2 apoptosis regulator.	0.503
AIFM1	ENSMLEP00000015528	ENSMLEP00000001405	ENSMLEP00000015528	Apoptosis inducing factor mitochondria associated 1.	Uncharacterized protein.	0.673
APAF1	AIFM1	ENSMLEP00000024091	ENSMLEP00000001405	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Apoptosis inducing factor mitochondria associated 1.	0.483
APAF1	BAK1	ENSMLEP00000024091	ENSMLEP00000018686	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 antagonist/killer 1.	0.751
APAF1	BAX	ENSMLEP00000024091	ENSMLEP00000003786	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 associated X, apoptosis regulator.	0.764
APAF1	BCL2	ENSMLEP00000024091	ENSMLEP00000005872	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2 apoptosis regulator.	0.844
APAF1	CASP12	ENSMLEP00000024091	ENSMLEP00000016884	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family.	0.870
APAF1	CASP4	ENSMLEP00000024091	ENSMLEP00000008929	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 4; Belongs to the peptidase C14A family.	0.870
APAF1	ENSMLEP00000015528	ENSMLEP00000024091	ENSMLEP00000015528	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.751
APAF1	TP53	ENSMLEP00000024091	ENSMLEP00000037099	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.775
ATF4	CHAC1	ENSMLEP00000005434	ENSMLEP00000015347	Activating transcription factor 4.	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	0.679
ATF4	DDIT3	ENSMLEP00000005434	ENSMLEP00000020226	Activating transcription factor 4.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.981
ATF4	PPP1R15A	ENSMLEP00000005434	ENSMLEP00000038761	Activating transcription factor 4.	Protein phosphatase 1 regulatory subunit 15A.	0.923
ATF4	TRIB3	ENSMLEP00000005434	ENSMLEP00000034910	Activating transcription factor 4.	Tribbles pseudokinase 3.	0.823
ATP2A1	ATP2A3	ENSMLEP00000001372	ENSMLEP00000010214	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	0.883
ATP2A3	ATP2A1	ENSMLEP00000010214	ENSMLEP00000001372	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.883
BAK1	AIFM1	ENSMLEP00000018686	ENSMLEP00000001405	BCL2 antagonist/killer 1.	Apoptosis inducing factor mitochondria associated 1.	0.673