(51 nodes) Protein K63-linked ubiquitination network (Mandrillus leucophaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RNF8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (449 aa)
	RNF213	Ring finger protein 213. (5005 aa)
	ITCH	E3 ubiquitin-protein ligase. (862 aa)
	UBE2O	Ubiquitin conjugating enzyme E2 O. (1099 aa)
	RNF126	Ring finger protein 126. (310 aa)
	TRAF3IP2	TRAF3 interacting protein 2. (569 aa)
	TRIM56	Tripartite motif containing 56. (750 aa)
	UBE2V2	Ubiquitin conjugating enzyme E2 V2. (155 aa)
	ENSMLEP00000018394	UBIQUITIN_CONJUGAT_2 domain-containing protein. (129 aa)
	NEDD4	NEDD4 E3 ubiquitin protein ligase. (1272 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	UBE2G1	Ubiquitin conjugating enzyme E2 G1; Belongs to the ubiquitin-conjugating enzyme family. (187 aa)
	RNF115	Ring finger protein 115. (304 aa)
	TRIM27	Tripartite motif containing 27. (513 aa)
	BFAR	Bifunctional apoptosis regulator. (362 aa)
	UBE2E3	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (207 aa)
	TRIM21	Tripartite motif containing 21. (475 aa)
	RNF168	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (565 aa)
	LOC105534357	RBR-type E3 ubiquitin transferase. (77 aa)
	PELI1	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
	LOC105540679	UBIQUITIN_CONJUGAT_2 domain-containing protein. (147 aa)
	ZFP91	Uncharacterized protein. (466 aa)
	LOC105537674	UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa)
	ENSMLEP00000005424	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (142 aa)
	LOC105534329	UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa)
	MAGEL2	MAGE family member L2. (1253 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	UBE2NL	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa)
	PELI3	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa)
	RNF152	Ring finger protein 152. (203 aa)
	UBE2T	Ubiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (197 aa)
	ARIH2	RBR-type E3 ubiquitin transferase. (471 aa)
	WWP2	E3 ubiquitin-protein ligase. (870 aa)
	PRPF19	Pre-mRNA processing factor 19. (504 aa)
	UBE2S	Uncharacterized protein. (79 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
	PRKN	Ubiquitin-like domain-containing protein. (368 aa)
	ENSMLEP00000035740	Uncharacterized protein. (185 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
	UBE2E2	Ubiquitin conjugating enzyme E2 E2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)
	LOC105539512	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
	TRIM5	Uncharacterized protein. (497 aa)
	RNF4	Ring finger protein 4. (190 aa)
	RNF5	Ring finger protein 5. (180 aa)
	STUB1	STIP1 homology and U-box containing protein 1. (250 aa)
	HECTD1	HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
	FBXW9	F-box and WD repeat domain containing 9. (458 aa)
	RNF135	Ring finger protein 135. (253 aa)
	ENSMLEP00000024603	UBIQUITIN_CONJUGAT_2 domain-containing protein. (102 aa)
	ENSMLEP00000024034	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (142 aa)
	TRAF1	TNF receptor-associated factor. (416 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BFAR	RNF8	ENSMLEP00000013619	ENSMLEP00000039177	Bifunctional apoptosis regulator.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.442
ENSMLEP00000005424	ENSMLEP00000024603	ENSMLEP00000005424	ENSMLEP00000024603	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.949
ENSMLEP00000005424	ENSMLEP00000035740	ENSMLEP00000005424	ENSMLEP00000035740	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Uncharacterized protein.	0.406
ENSMLEP00000005424	LOC105534329	ENSMLEP00000005424	ENSMLEP00000005224	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.839
ENSMLEP00000005424	LOC105534357	ENSMLEP00000005424	ENSMLEP00000008246	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	RBR-type E3 ubiquitin transferase.	0.687
ENSMLEP00000005424	LOC105537674	ENSMLEP00000005424	ENSMLEP00000006693	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.839
ENSMLEP00000005424	LOC105540679	ENSMLEP00000005424	ENSMLEP00000007659	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.949
ENSMLEP00000005424	PELI1	ENSMLEP00000005424	ENSMLEP00000008168	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.467
ENSMLEP00000005424	PELI3	ENSMLEP00000005424	ENSMLEP00000001096	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.466
ENSMLEP00000005424	PRKN	ENSMLEP00000005424	ENSMLEP00000037171	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-like domain-containing protein.	0.687
ENSMLEP00000005424	RNF135	ENSMLEP00000005424	ENSMLEP00000025027	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ring finger protein 135.	0.436
ENSMLEP00000005424	RNF152	ENSMLEP00000005424	ENSMLEP00000000992	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ring finger protein 152.	0.406
ENSMLEP00000005424	RNF168	ENSMLEP00000005424	ENSMLEP00000009198	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...]	0.865
ENSMLEP00000005424	RNF4	ENSMLEP00000005424	ENSMLEP00000027750	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ring finger protein 4.	0.808
ENSMLEP00000005424	RNF8	ENSMLEP00000005424	ENSMLEP00000039177	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.882
ENSMLEP00000005424	STUB1	ENSMLEP00000005424	ENSMLEP00000026385	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	STIP1 homology and U-box containing protein 1.	0.859
ENSMLEP00000005424	TRAF1	ENSMLEP00000005424	ENSMLEP00000023948	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	TNF receptor-associated factor.	0.441
ENSMLEP00000005424	TRAF2	ENSMLEP00000005424	ENSMLEP00000037495	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.755
ENSMLEP00000005424	TRAF3	ENSMLEP00000005424	ENSMLEP00000017560	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.443
ENSMLEP00000005424	TRAF5	ENSMLEP00000005424	ENSMLEP00000033678	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.472