STRINGSTRING
CTC1 CTC1 NF1 NF1 ARIH2 ARIH2 SIX2 SIX2 BABAM1 BABAM1 WNT3 WNT3 ETV6 ETV6 ERCC2 ERCC2 RNF43 RNF43 TP53 TP53 ENSMLEP00000037023 ENSMLEP00000037023 PRRX1 PRRX1 NR2E1 NR2E1 BYSL BYSL KDF1 KDF1 YAP1 YAP1 XRCC5 XRCC5 CEP120 CEP120 HOXA3 HOXA3 SFRP2 SFRP2 CDKN2C CDKN2C KDR KDR FGF8 FGF8 WNT5A WNT5A OVOL1 OVOL1 MECOM MECOM WNT7B WNT7B BRCA2 BRCA2 NES NES RARB RARB TIAL1 TIAL1 SNAI2 SNAI2 NFIB NFIB SART3 SART3 OSR2 OSR2 SHB SHB PTCH1 PTCH1 WNT2B WNT2B CD34 CD34 PBX1 PBX1 TRIM71 TRIM71 IFT20 IFT20 YTHDF2 YTHDF2 HOXB4 HOXB4 RUNX2 RUNX2 FGF9 FGF9 FGF10 FGF10 AXIN2 AXIN2 CTNNB1 CTNNB1 GLI3 GLI3 RUNX1 RUNX1 ELL3 ELL3 LIG4 LIG4 RARG RARG WNT10B WNT10B CD109 CD109 HMX2 HMX2 TGFB1 TGFB1 WNT11 WNT11 LOC105540906 LOC105540906 WNT1 WNT1 TBX3 TBX3 SCRG1 SCRG1 LOC105540905 LOC105540905 IRF6 IRF6 SHOX2 SHOX2 TP63 TP63
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTC1CST telomere replication complex component 1. (1217 aa)
NF1Neurofibromin 1. (2839 aa)
ARIH2RBR-type E3 ubiquitin transferase. (471 aa)
SIX2SIX homeobox 2. (290 aa)
BABAM1BRISC and BRCA1 A complex member 1. (254 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
ETV6ETS variant 6. (452 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
RNF43RING-type domain-containing protein. (783 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
ENSMLEP00000037023HH_signal domain-containing protein. (126 aa)
PRRX1Paired related homeobox 1. (245 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (421 aa)
BYSLBystin like. (437 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
YAP1Yes associated protein 1. (497 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
CEP120Centrosomal protein 120. (986 aa)
HOXA3Homeobox A3. (443 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
OVOL1Ovo like transcriptional repressor 1. (267 aa)
MECOMMDS1 and EVI1 complex locus. (1230 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
BRCA2BRCA2 DNA repair associated. (3675 aa)
NESNestin; Belongs to the intermediate filament family. (1398 aa)
RARBRetinoic acid receptor beta. (448 aa)
TIAL1TIA1 cytotoxic granule associated RNA binding protein like 1. (396 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
SART3Spliceosome associated factor 3, U4/U6 recycling protein. (981 aa)
OSR2Odd-skipped related transciption factor 2. (402 aa)
SHBSH2 domain containing adaptor protein B. (297 aa)
PTCH1Patched 1. (1379 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
CD34CD34 molecule. (385 aa)
PBX1PBX homeobox 1. (430 aa)
TRIM71Tripartite motif containing 71. (620 aa)
IFT20Uncharacterized protein. (144 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (576 aa)
HOXB4Homeobox B4. (133 aa)
RUNX2RUNX family transcription factor 2. (471 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
AXIN2Axin 2. (843 aa)
CTNNB1Catenin beta 1. (781 aa)
GLI3GLI family zinc finger 3. (1580 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
ELL3Elongation factor for RNA polymerase II 3. (390 aa)
LIG4DNA ligase. (911 aa)
RARGRetinoic acid receptor gamma. (457 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
CD109CD109 molecule. (1383 aa)
HMX2H6 family homeobox 2. (273 aa)
TGFB1Transforming growth factor beta 1. (226 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (289 aa)
LOC10554090614-3-3 protein sigma. (248 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (287 aa)
TBX3T-box transcription factor 3. (743 aa)
SCRG1Stimulator of chondrogenesis 1. (98 aa)
LOC10554090514_3_3 domain-containing protein; Belongs to the 14-3-3 family. (248 aa)
IRF6Interferon regulatory factor 6. (467 aa)
SHOX2Short stature homeobox 2. (304 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (595 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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