STRINGSTRING
PPIL1 PPIL1 GJA5 GJA5 NCOA3 NCOA3 DFFB DFFB EZR EZR CTNNB1 CTNNB1 FKBP8 FKBP8 CALM1 CALM1 NUMA1 NUMA1 AP2A2 AP2A2 ENSMLEP00000012358 ENSMLEP00000012358 CLTC CLTC FYN FYN TEAD2 TEAD2 CALM2 CALM2 RB1 RB1 KEAP1 KEAP1 AP2M1 AP2M1 SMAD2 SMAD2 FN1 FN1 HSPA2 HSPA2 SMTNL1 SMTNL1 CALM3 CALM3 ENSMLEP00000036212 ENSMLEP00000036212 TP53 TP53 RRM1 RRM1 GAPDH GAPDH LOC105540811 LOC105540811
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPIL1Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (166 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
NCOA3Nuclear receptor coactivator. (1403 aa)
DFFBCIDE-N domain-containing protein. (353 aa)
EZREzrin. (588 aa)
CTNNB1Catenin beta 1. (781 aa)
FKBP8Peptidylprolyl isomerase. (413 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2127 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (939 aa)
ENSMLEP00000012358CIDE-N domain-containing protein. (316 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1679 aa)
FYNTyrosine-protein kinase. (537 aa)
TEAD2TEA domain transcription factor 2. (451 aa)
CALM2Calmodulin 2. (149 aa)
RB1RB transcriptional corepressor 1. (891 aa)
KEAP1Kelch like ECH associated protein 1. (624 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (458 aa)
SMAD2Mothers against decapentaplegic homolog. (457 aa)
FN1Fibronectin 1. (2384 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (600 aa)
SMTNL1Smoothelin like 1. (496 aa)
CALM3Calmodulin 3. (149 aa)
ENSMLEP00000036212Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (157 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
LOC105540811Uncharacterized protein; Belongs to the calmodulin family. (128 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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