STRINGSTRING
ERCC2 ERCC2 TRAF3 TRAF3 GTF2H5 GTF2H5 STING1 STING1 DAPK1 DAPK1 LOC105548148 LOC105548148 CDK7 CDK7 CCNF CCNF ERN1 ERN1 LAS1L LAS1L CCND3 CCND3 PRKDC PRKDC CDK5 CDK5 STRADA STRADA ACVR1C ACVR1C CCNG2 CCNG2 STRADB STRADB TGFBR1 TGFBR1 CCNL2 CCNL2 MNAT1 MNAT1 ENSMLEP00000022318 ENSMLEP00000022318 CCNI CCNI CKS2 CKS2 TBK1 TBK1 CHUK CHUK PHKA1 PHKA1 PHKB PHKB IGF1R IGF1R NEK10 NEK10 SESN2 SESN2 LOC105546826 LOC105546826 ENSMLEP00000025175 ENSMLEP00000025175 AMHR2 AMHR2 CCNO CCNO ENSMLEP00000025412 ENSMLEP00000025412 CDK6 CDK6 CDK4 CDK4 ACVR1 ACVR1 GTF2H3 GTF2H3 PRKAG2 PRKAG2 CNTD2 CNTD2 PHKG1 PHKG1 STK11 STK11 CCNA1 CCNA1 TRIM40 TRIM40 CDK14 CDK14 SMCR8 SMCR8 CDK12 CDK12 PRKAR2A PRKAR2A CCNE1 CCNE1 PRKCI PRKCI CCNQ CCNQ TGFB3 TGFB3 ENSMLEP00000031820 ENSMLEP00000031820 TANK TANK PHKG2 PHKG2 ENSMLEP00000033047 ENSMLEP00000033047 PRKAG1 PRKAG1 MAP3K6 MAP3K6 PRKAB2 PRKAB2 CDK13 CDK13 CCND2 CCND2 XRCC5 XRCC5 CCNA2 CCNA2 PRKAA1 PRKAA1 TGFBR2 TGFBR2 GTF2H1 GTF2H1 CCNK CCNK LOC105541671 LOC105541671 ENSMLEP00000037154 ENSMLEP00000037154 ULK1 ULK1 GTF2H4 GTF2H4 ENSMLEP00000038171 ENSMLEP00000038171 CCNJL CCNJL CDK1 CDK1 BCCIP BCCIP ATG101 ATG101 CCNT1 CCNT1 MMS19 MMS19 CCNB3 CCNB3 ZBTB7A ZBTB7A MAP3K5 MAP3K5 ENSMLEP00000040613 ENSMLEP00000040613 CCNT2 CCNT2 CDK10 CDK10 IKBKB IKBKB INSR INSR ENSMLEP00000017044 ENSMLEP00000017044 CCNL1 CCNL1 PARD6A PARD6A RB1CC1 RB1CC1 IKBKE IKBKE CDK16 CDK16 CCNE2 CCNE2 CCNH CCNH CKS1B CKS1B CDKN1A CDKN1A LOC105543372 LOC105543372 PHKA2 PHKA2 INSRR INSRR IRS1 IRS1 ACVR2B ACVR2B ACVR2A ACVR2A CCNB1 CCNB1 ERC1 ERC1 MAP3K15 MAP3K15 PYDC1 PYDC1 LOC105553920 LOC105553920 PRKAG3 PRKAG3 ATG13 ATG13 CDK3 CDK3 SOWAHB SOWAHB ACVR1B ACVR1B PRKAB1 PRKAB1 CCNJ CCNJ PYCARD PYCARD XRCC6 XRCC6 CAB39 CAB39 PRKAA2 PRKAA2 CDK9 CDK9 PCNA PCNA TGFB1 TGFB1 CCNI2 CCNI2 CCNY CCNY CDK5R1 CDK5R1 CDK2 CDK2 CCNC CCNC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
GTF2H5General transcription factor IIH subunit 5. (71 aa)
STING1Transmembrane protein 173. (379 aa)
DAPK1Death associated protein kinase 1. (1430 aa)
LOC105548148Protein kinase domain-containing protein. (312 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
CCNFCyclin F; Belongs to the cyclin family. (786 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (959 aa)
LAS1LLAS1 like, ribosome biogenesis factor. (739 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (242 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit. (3556 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (302 aa)
STRADASTE20 related adaptor alpha. (431 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (344 aa)
STRADBSTE20 related adaptor beta. (377 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
CCNL2Cyclin L2; Belongs to the cyclin family. (347 aa)
MNAT1MNAT1 component of CDK activating kinase. (234 aa)
ENSMLEP00000022318PDZ domain-containing protein. (197 aa)
CCNICyclin I; Belongs to the cyclin family. (252 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
TBK1TANK binding kinase 1. (729 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1240 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (900 aa)
IGF1RTyrosine-protein kinase receptor. (1281 aa)
NEK10NIMA related kinase 10. (1159 aa)
SESN2Sestrin 2. (450 aa)
LOC105546826BRCA2 and CDKN1A-interacting protein; May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ); Belongs to the BCP1 family. (300 aa)
ENSMLEP00000025175Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (171 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (573 aa)
CCNOCyclin O; Belongs to the cyclin family. (350 aa)
ENSMLEP00000025412Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (69 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
GTF2H3General transcription factor IIH subunit 3. (308 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (506 aa)
CNTD2Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (198 aa)
PHKG1Phosphorylase kinase catalytic subunit gamma 1; Belongs to the protein kinase superfamily. (421 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
TRIM40Tripartite motif containing 40. (258 aa)
CDK14Cyclin dependent kinase 14; Belongs to the protein kinase superfamily. (469 aa)
SMCR8SMCR8-C9orf72 complex subunit. (936 aa)
CDK12Cyclin dependent kinase 12. (1451 aa)
PRKAR2AUncharacterized protein. (211 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (407 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (583 aa)
CCNQCYCLIN domain-containing protein; Belongs to the cyclin family. (226 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ENSMLEP00000031820CYCLIN domain-containing protein; Belongs to the cyclin family. (295 aa)
TANKTRAF family member associated NFKB activator. (425 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (410 aa)
ENSMLEP00000033047Uncharacterized protein. (67 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (326 aa)
MAP3K6Mitogen-activated protein kinase kinase kinase 6. (1288 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
CDK13Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (418 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (560 aa)
GTF2H1General transcription factor IIH subunit 1. (548 aa)
CCNKCyclin K; Belongs to the cyclin family. (580 aa)
LOC105541671Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (252 aa)
ENSMLEP00000037154Uncharacterized protein. (223 aa)
ULK1Unc-51 like autophagy activating kinase 1. (996 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (462 aa)
ENSMLEP00000038171Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (66 aa)
CCNJLCyclin J like; Belongs to the cyclin family. (433 aa)
CDK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
BCCIPBRCA2 and CDKN1A interacting protein. (322 aa)
ATG101Autophagy related 101. (218 aa)
CCNT1Cyclin T1; Belongs to the cyclin family. (728 aa)
MMS19MMS19 homolog, cytosolic iron-sulfur assembly component. (1030 aa)
CCNB3Cyclin B3; Belongs to the cyclin family. (1365 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (347 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1306 aa)
ENSMLEP00000040613Protein kinase domain-containing protein. (286 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (730 aa)
CDK10Cyclin dependent kinase 10; Belongs to the protein kinase superfamily. (331 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (706 aa)
INSRTyrosine-protein kinase receptor. (1301 aa)
ENSMLEP00000017044Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (86 aa)
CCNL1Cyclin L1; Belongs to the cyclin family. (526 aa)
PARD6APar-6 family cell polarity regulator alpha. (345 aa)
RB1CC1RB1 inducible coiled-coil 1. (1570 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (697 aa)
CDK16Cyclin dependent kinase 16. (570 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
CCNHCyclin H; Belongs to the cyclin family. (325 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
LOC105543372General transcription factor IIH subunit. (380 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1235 aa)
INSRRTyrosine-protein kinase receptor. (1301 aa)
IRS1Insulin receptor substrate 1. (1242 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (433 aa)
ERC1ELKS/RAB6-interacting/CAST family member 1. (1120 aa)
MAP3K15Mitogen-activated protein kinase kinase kinase 15. (1192 aa)
PYDC1Pyrin domain containing 1. (92 aa)
LOC105553920BSD domain-containing protein. (430 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
SOWAHBSosondowah ankyrin repeat domain family member B. (793 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
CCNJCyclin J; Belongs to the cyclin family. (383 aa)
PYCARDPYD and CARD domain containing. (195 aa)
XRCC6X-ray repair cross complementing 6. (615 aa)
CAB39Calcium binding protein 39. (341 aa)
PRKAA2Non-specific serine/threonine protein kinase. (542 aa)
CDK9Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
TGFB1Transforming growth factor beta 1. (226 aa)
CCNI2Cyclin I family member 2; Belongs to the cyclin family. (261 aa)
CCNYCyclin Y; Belongs to the cyclin family. (341 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
CCNCCyclin C; Belongs to the cyclin family. (283 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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