(47 nodes) Positive regulation of neural precursor cell proliferation network (Mandrillus leucophaeus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	ZNF335	Zinc finger protein 335. (1346 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	NES	Nestin; Belongs to the intermediate filament family. (1398 aa)
	LHX2	LIM homeobox 2. (407 aa)
	LOC105530554	Uncharacterized protein. (143 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (785 aa)
	MDK	Uncharacterized protein. (161 aa)
	DISC1	DISC1 scaffold protein. (858 aa)
	WDR62	WD repeat domain 62. (1523 aa)
	CTF1	Uncharacterized protein. (202 aa)
	DISP3	Dispatched RND transporter family member 3. (1391 aa)
	LHX5	LIM homeobox 5. (382 aa)
	GLI3	GLI family zinc finger 3. (1580 aa)
	ASPM	Abnormal spindle microtubule assembly. (3476 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	LYN	Tyrosine-protein kinase. (470 aa)
	KDM1A	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (832 aa)
	TOX	Thymocyte selection associated high mobility group box. (492 aa)
	OTP	Orthopedia homeobox. (325 aa)
	CDON	Cell adhesion associated, oncogene regulated. (1287 aa)
	CX3CL1	C-X3-C motif chemokine ligand 1. (402 aa)
	ELL3	Elongation factor for RNA polymerase II 3. (390 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1152 aa)
	FOXG1	Uncharacterized protein. (151 aa)
	DMRTA2	DMRT like family A2. (538 aa)
	ASCL1	Achaete-scute family bHLH transcription factor 1. (228 aa)
	LRP2	LDL receptor related protein 2. (4655 aa)
	PAX6	Paired box 6. (520 aa)
	LHX1	LIM homeobox 1. (406 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (758 aa)
	DRD2	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
	VEGFC	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (402 aa)
	CX3CR1	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (384 aa)
	GLI1	GLI family zinc finger 1. (1106 aa)
	GPR37L1	G protein-coupled receptor 37 like 1. (481 aa)
	ENSMLEP00000037023	HH_signal domain-containing protein. (126 aa)
	CIP2A	Cell proliferation regulating inhibitor of protein phosphatase 2A. (852 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (421 aa)
	ENSMLEP00000034253	Homeobox domain-containing protein. (125 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
	SOX10	SRY-box transcription factor 10. (420 aa)
	RASSF10	Ras association domain family member 10. (507 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
	NOTCH1	Notch receptor 1. (2076 aa)
	DCT	Dopachrome tautomerase. (519 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL1	FOXG1	ENSMLEP00000010401	ENSMLEP00000005882	Achaete-scute family bHLH transcription factor 1.	Uncharacterized protein.	0.492
ASCL1	GLI1	ENSMLEP00000010401	ENSMLEP00000038066	Achaete-scute family bHLH transcription factor 1.	GLI family zinc finger 1.	0.510
ASCL1	LHX2	ENSMLEP00000010401	ENSMLEP00000004785	Achaete-scute family bHLH transcription factor 1.	LIM homeobox 2.	0.424
ASCL1	NES	ENSMLEP00000010401	ENSMLEP00000021277	Achaete-scute family bHLH transcription factor 1.	Nestin; Belongs to the intermediate filament family.	0.513
ASCL1	PAX6	ENSMLEP00000010401	ENSMLEP00000011841	Achaete-scute family bHLH transcription factor 1.	Paired box 6.	0.586
ASPM	WDR62	ENSMLEP00000007854	ENSMLEP00000026457	Abnormal spindle microtubule assembly.	WD repeat domain 62.	0.799
ASPM	ZNF335	ENSMLEP00000007854	ENSMLEP00000020904	Abnormal spindle microtubule assembly.	Zinc finger protein 335.	0.562
CDON	CTNNB1	ENSMLEP00000029403	ENSMLEP00000009207	Cell adhesion associated, oncogene regulated.	Catenin beta 1.	0.498
CDON	ENSMLEP00000037023	ENSMLEP00000029403	ENSMLEP00000037023	Cell adhesion associated, oncogene regulated.	HH_signal domain-containing protein.	0.983
CDON	GLI1	ENSMLEP00000029403	ENSMLEP00000038066	Cell adhesion associated, oncogene regulated.	GLI family zinc finger 1.	0.405
CDON	LRP2	ENSMLEP00000029403	ENSMLEP00000010739	Cell adhesion associated, oncogene regulated.	LDL receptor related protein 2.	0.901
CDON	SMO	ENSMLEP00000029403	ENSMLEP00000003293	Cell adhesion associated, oncogene regulated.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.718
CTNNB1	CDON	ENSMLEP00000009207	ENSMLEP00000029403	Catenin beta 1.	Cell adhesion associated, oncogene regulated.	0.498
CTNNB1	EGF	ENSMLEP00000009207	ENSMLEP00000006087	Catenin beta 1.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.559
CTNNB1	ENSMLEP00000037023	ENSMLEP00000009207	ENSMLEP00000037023	Catenin beta 1.	HH_signal domain-containing protein.	0.570
CTNNB1	FOXG1	ENSMLEP00000009207	ENSMLEP00000005882	Catenin beta 1.	Uncharacterized protein.	0.552
CTNNB1	FZD3	ENSMLEP00000009207	ENSMLEP00000032256	Catenin beta 1.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.514
CTNNB1	GLI1	ENSMLEP00000009207	ENSMLEP00000038066	Catenin beta 1.	GLI family zinc finger 1.	0.431
CTNNB1	HIF1A	ENSMLEP00000009207	ENSMLEP00000016423	Catenin beta 1.	Hypoxia inducible factor 1 subunit alpha.	0.821
CTNNB1	KDM1A	ENSMLEP00000009207	ENSMLEP00000000763	Catenin beta 1.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.421