(22 nodes) Positive regulation of excitatory postsynaptic potential network (Mandrillus leucophaeus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	DLG4	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
	NRXN1	Neurexin 1. (1182 aa)
	ENSMLEP00000001003	CaM_bdg_C0 domain-containing protein. (124 aa)
	NLGN1	Neuroligin 1. (823 aa)
	ADRB2	Adrenoceptor beta 2. (415 aa)
	ENSMLEP00000003309	PDZ domain-containing protein. (442 aa)
	BAIAP2	BAI1 associated protein 2. (490 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	PRKCZ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
	ENSMLEP00000018922	ANF_receptor domain-containing protein. (356 aa)
	NETO1	Neuropilin and tolloid like 1. (529 aa)
	STX1B	Syntaxin 1B; Belongs to the syntaxin family. (245 aa)
	NLGN2	Neuroligin 2. (834 aa)
	GRIN2D	Glutamate ionotropic receptor NMDA type subunit 2D. (747 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	RIMS1	Regulating synaptic membrane exocytosis 1. (1692 aa)
	IGSF11	Immunoglobulin superfamily member 11. (431 aa)
	CUX2	DNA-binding protein SATB. (1429 aa)
	STX1A	Syntaxin 1A; Belongs to the syntaxin family. (288 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
	SHANK1	SH3 and multiple ankyrin repeat domains 1. (1674 aa)
	RELN	Reelin. (3480 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRB2	DLG4	ENSMLEP00000003176	ENSMLEP00000032079	Adrenoceptor beta 2.	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	0.446
BAIAP2	DLG4	ENSMLEP00000009635	ENSMLEP00000032079	BAI1 associated protein 2.	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	0.626
BAIAP2	PTK2B	ENSMLEP00000009635	ENSMLEP00000013835	BAI1 associated protein 2.	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.458
BAIAP2	SHANK1	ENSMLEP00000009635	ENSMLEP00000040464	BAI1 associated protein 2.	SH3 and multiple ankyrin repeat domains 1.	0.448
DLG4	ADRB2	ENSMLEP00000032079	ENSMLEP00000003176	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Adrenoceptor beta 2.	0.446
DLG4	BAIAP2	ENSMLEP00000032079	ENSMLEP00000009635	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	BAI1 associated protein 2.	0.626
DLG4	ENSMLEP00000001003	ENSMLEP00000032079	ENSMLEP00000001003	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	CaM_bdg_C0 domain-containing protein.	0.946
DLG4	ENSMLEP00000003309	ENSMLEP00000032079	ENSMLEP00000003309	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	PDZ domain-containing protein.	0.534
DLG4	ENSMLEP00000018922	ENSMLEP00000032079	ENSMLEP00000018922	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	ANF_receptor domain-containing protein.	0.986
DLG4	GRIN2D	ENSMLEP00000032079	ENSMLEP00000024154	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Glutamate ionotropic receptor NMDA type subunit 2D.	0.958
DLG4	NLGN1	ENSMLEP00000032079	ENSMLEP00000001010	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Neuroligin 1.	0.876
DLG4	NLGN2	ENSMLEP00000032079	ENSMLEP00000023886	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Neuroligin 2.	0.743
DLG4	NRXN1	ENSMLEP00000032079	ENSMLEP00000000155	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Neurexin 1.	0.649
DLG4	PTEN	ENSMLEP00000032079	ENSMLEP00000025562	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.512
DLG4	PTK2B	ENSMLEP00000032079	ENSMLEP00000013835	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.472
DLG4	RIMS1	ENSMLEP00000032079	ENSMLEP00000032705	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	Regulating synaptic membrane exocytosis 1.	0.402
DLG4	SHANK1	ENSMLEP00000032079	ENSMLEP00000040464	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	SH3 and multiple ankyrin repeat domains 1.	0.805
ENSMLEP00000001003	DLG4	ENSMLEP00000001003	ENSMLEP00000032079	CaM_bdg_C0 domain-containing protein.	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	0.946
ENSMLEP00000001003	ENSMLEP00000003309	ENSMLEP00000001003	ENSMLEP00000003309	CaM_bdg_C0 domain-containing protein.	PDZ domain-containing protein.	0.425
ENSMLEP00000001003	ENSMLEP00000018922	ENSMLEP00000001003	ENSMLEP00000018922	CaM_bdg_C0 domain-containing protein.	ANF_receptor domain-containing protein.	0.921