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KCNJ16 KCNJ16 KCNK6 KCNK6 KCNMB4 KCNMB4 HTR2A HTR2A KCNA5 KCNA5 SCN9A SCN9A MCUB MCUB KCNJ1 KCNJ1 CATSPER4 CATSPER4 HTR3B HTR3B CACNA1S CACNA1S CACNA2D3 CACNA2D3 OLFM3 OLFM3 SMDT1 SMDT1 CNIH2 CNIH2 KCNJ5 KCNJ5 MCU MCU SCN2B SCN2B FKBP1A FKBP1A CACNA2D1 CACNA2D1 KCNN1 KCNN1 KCNJ14 KCNJ14 HCN3 HCN3 CCDC51 CCDC51 NIPAL3 NIPAL3 STAC3 STAC3 ENSMLEP00000039257 ENSMLEP00000039257 TMEM262 TMEM262 CACNG4 CACNG4 CACNA2D4 CACNA2D4 KCND1 KCND1 PDE4D PDE4D SHISA9 SHISA9 KCNJ4 KCNJ4 KCNK4 KCNK4 CATSPERZ CATSPERZ CATSPERB CATSPERB CATSPER1 CATSPER1 LRRTM4 LRRTM4 GRIK4 GRIK4 CACNA1H CACNA1H TMEM249 TMEM249 KCNJ8 KCNJ8 CACNB3 CACNB3 CNGB1 CNGB1 NIPAL2 NIPAL2 AMIGO1 AMIGO1 LOC105540811 LOC105540811 CNGA4 CNGA4 KCNG3 KCNG3 KCNH4 KCNH4 CNGA3 CNGA3 SCN3A SCN3A KCNJ11 KCNJ11 KCNH2 KCNH2 ABCC8 ABCC8 CNGA2 CNGA2 CTTN CTTN ENSMLEP00000001003 ENSMLEP00000001003 GRIA3 GRIA3 CALM1 CALM1 ENSMLEP00000010338 ENSMLEP00000010338 SCN10A SCN10A ENSMLEP00000010239 ENSMLEP00000010239 CATSPER3 CATSPER3 ITPR1 ITPR1 LOC105537369 LOC105537369 LRRC52 LRRC52 ABCC9 ABCC9 MICU1 MICU1 KCNA3 KCNA3 TRPC5 TRPC5 SCN1A SCN1A TRPC4 TRPC4 CACNB1 CACNB1 VWC2L VWC2L CATSPERD CATSPERD LRRC38 LRRC38 CACNG7 CACNG7 GRIA4 GRIA4 HTR3C HTR3C KCNQ4 KCNQ4 CACNG2 CACNG2 KCNMB3 KCNMB3 SCN4B SCN4B CACNB4 CACNB4 SCN8A SCN8A HCN4 HCN4 SCNN1D SCNN1D CACNA2D2 CACNA2D2 DPP6 DPP6 ABCB8 ABCB8 ORAI1 ORAI1 KCNIP1 KCNIP1 DLG3 DLG3 CACNB2 CACNB2 CACNG5 CACNG5 GRIN3A GRIN3A ENSMLEP00000018922 ENSMLEP00000018922 KCNIP4 KCNIP4 CALM2 CALM2 CACNG1 CACNG1 KCNN4 KCNN4 CNGB3 CNGB3 CACNG3 CACNG3 ENSMLEP00000020666 ENSMLEP00000020666 CACNA1E CACNA1E SCN1B SCN1B HCN1 HCN1 CATSPERE CATSPERE CACNA1F CACNA1F DPP10 DPP10 ENSMLEP00000022028 ENSMLEP00000022028 CACNA1G CACNA1G KCNQ5 KCNQ5 ITPR3 ITPR3 OLFM2 OLFM2 CATSPERG CATSPERG PEX5L PEX5L GRIK5 GRIK5 GRIN2D GRIN2D AKAP6 AKAP6 KCNJ3 KCNJ3 MICU2 MICU2 GRIA2 GRIA2 KCNB2 KCNB2 KCNMB2 KCNMB2 CNIH3 CNIH3 KCNMA1 KCNMA1 SCN5A SCN5A GRIN2C GRIN2C KCNA6 KCNA6 AKAP9 AKAP9 MICU3 MICU3 GRIN2A GRIN2A SCN3B SCN3B KCNG4 KCNG4 SCN2A SCN2A HTR3E HTR3E KCNIP3 KCNIP3 CACNA1I CACNA1I HTR3A HTR3A HSPA2 HSPA2 SCN4A SCN4A FBXL6 FBXL6 SCN7A SCN7A CNGA1 CNGA1 PDE4B PDE4B TRPM4 TRPM4 LRRC55 LRRC55 VWC2 VWC2 DLG4 DLG4 CACNA1A CACNA1A KCNK1 KCNK1 TRPC1 TRPC1 CACNA1B CACNA1B KCNIP2 KCNIP2 GRIN3B GRIN3B CALM3 CALM3 CACNG6 CACNG6 ENSMLEP00000033212 ENSMLEP00000033212
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KCNJ16Potassium voltage-gated channel subfamily J member 16. (457 aa)
KCNK6Potassium channel subfamily K member. (313 aa)
KCNMB4Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (210 aa)
HTR2A5-hydroxytryptamine receptor 2A. (471 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (605 aa)
SCN9ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1977 aa)
MCUBMitochondrial calcium uniporter dominant negative beta subunit. (303 aa)
KCNJ1Potassium voltage-gated channel subfamily J member 1. (391 aa)
CATSPER4Cation channel sperm associated 4. (484 aa)
HTR3B5-hydroxytryptamine receptor 3B; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (441 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1846 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (1050 aa)
OLFM3Olfactomedin 3. (478 aa)
SMDT1Single-pass membrane protein with aspartate rich tail 1. (107 aa)
CNIH2Cornichon family AMPA receptor auxiliary protein 2. (133 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
MCUMitochondrial calcium uniporter. (318 aa)
SCN2BSodium voltage-gated channel beta subunit 2. (215 aa)
FKBP1APeptidylprolyl isomerase. (145 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1018 aa)
KCNN1Potassium calcium-activated channel subfamily N member 1. (523 aa)
KCNJ14Potassium voltage-gated channel subfamily J member 14. (436 aa)
HCN3Hyperpolarization activated cyclic nucleotide gated potassium channel 3. (763 aa)
CCDC51Coiled-coil domain containing 51. (411 aa)
NIPAL3NIPA like domain containing 3. (406 aa)
STAC3SH3 and cysteine rich domain 3. (364 aa)
ENSMLEP00000039257Uncharacterized protein. (300 aa)
TMEM262Transmembrane protein 262. (116 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (346 aa)
CACNA2D4Calcium voltage-gated channel auxiliary subunit alpha2delta 4. (1137 aa)
KCND1Potassium voltage-gated channel subfamily D member 1; Belongs to the potassium channel family. (647 aa)
PDE4DPhosphodiesterase. (748 aa)
SHISA9Shisa family member 9. (366 aa)
KCNJ4Potassium voltage-gated channel subfamily J member 4. (445 aa)
KCNK4Potassium two pore domain channel subfamily K member 4; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (393 aa)
CATSPERZCatsper channel auxiliary subunit zeta. (200 aa)
CATSPERBCation channel sperm associated auxiliary subunit beta. (1115 aa)
CATSPER1Cation channel sperm associated 1. (768 aa)
LRRTM4Leucine rich repeat transmembrane neuronal 4. (591 aa)
GRIK4Glutamate ionotropic receptor kainate type subunit 4. (959 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2170 aa)
TMEM249Transmembrane protein 249. (234 aa)
KCNJ8Potassium voltage-gated channel subfamily J member 8. (424 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
CNGB1Cyclic nucleotide gated channel subunit beta 1. (1247 aa)
NIPAL2NIPA like domain containing 2. (338 aa)
AMIGO1Adhesion molecule with Ig like domain 1. (493 aa)
LOC105540811Uncharacterized protein; Belongs to the calmodulin family. (128 aa)
CNGA4Cyclic nucleotide gated channel subunit alpha 4. (575 aa)
KCNG3Potassium voltage-gated channel modifier subfamily G member 3; Belongs to the potassium channel family. (288 aa)
KCNH4Potassium voltage-gated channel subfamily H member 4. (1006 aa)
CNGA3Cyclic nucleotide gated channel subunit alpha 3. (694 aa)
SCN3ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2000 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (991 aa)
ABCC8ATP binding cassette subfamily C member 8. (1582 aa)
CNGA2Cyclic nucleotide gated channel subunit alpha 2. (664 aa)
CTTNCortactin. (550 aa)
ENSMLEP00000001003CaM_bdg_C0 domain-containing protein. (124 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
ENSMLEP00000010338Ion_trans domain-containing protein. (257 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1959 aa)
ENSMLEP00000010239Peptidylprolyl isomerase. (133 aa)
CATSPER3Cation channel sperm associated 3. (398 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2731 aa)
LOC105537369Ion_trans domain-containing protein. (472 aa)
LRRC52Leucine rich repeat containing 52. (342 aa)
ABCC9ATP binding cassette subfamily C member 9. (1549 aa)
MICU1Uncharacterized protein. (482 aa)
KCNA3Potassium voltage-gated channel subfamily A member 3; Belongs to the potassium channel family. (575 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (974 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1912 aa)
TRPC4Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (982 aa)
CACNB1Calcium voltage-gated channel auxiliary subunit beta 1. (643 aa)
VWC2LVon Willebrand factor C domain containing 2 like. (222 aa)
CATSPERDCation channel sperm associated auxiliary subunit delta. (712 aa)
LRRC38LRRCT domain-containing protein. (256 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (902 aa)
HTR3C5-hydroxytryptamine receptor 3C; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (405 aa)
KCNQ4Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family. (608 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (262 aa)
KCNMB3Potassium calcium-activated channel subfamily M regulatory beta subunit 3. (270 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (228 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (490 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1980 aa)
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1035 aa)
SCNN1DSodium channel epithelial 1 delta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (689 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1081 aa)
DPP6Dipeptidyl peptidase like 6; Belongs to the peptidase S9B family. (803 aa)
ABCB8ATP binding cassette subfamily B member 8. (703 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (238 aa)
KCNIP1Potassium voltage-gated channel interacting protein 1. (241 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (862 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1115 aa)
ENSMLEP00000018922ANF_receptor domain-containing protein. (356 aa)
KCNIP4Potassium voltage-gated channel interacting protein 4. (230 aa)
CALM2Calmodulin 2. (149 aa)
CACNG1Calcium voltage-gated channel auxiliary subunit gamma 1. (197 aa)
KCNN4Potassium calcium-activated channel subfamily N member 4. (375 aa)
CNGB3Cyclic nucleotide gated channel subunit beta 3. (415 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
ENSMLEP00000020666EF-hand domain-containing protein. (462 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2315 aa)
SCN1BSodium voltage-gated channel beta subunit 1. (236 aa)
HCN1Hyperpolarization activated cyclic nucleotide gated potassium channel 1. (748 aa)
CATSPERECatsper channel auxiliary subunit epsilon. (906 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1960 aa)
DPP10Dipeptidyl peptidase like 10; Belongs to the peptidase S9B family. (737 aa)
ENSMLEP00000022028Uncharacterized protein. (286 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2360 aa)
KCNQ5Potassium voltage-gated channel subfamily Q member 5. (878 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2675 aa)
OLFM2Olfactomedin 2. (453 aa)
CATSPERGCation channel sperm associated auxiliary subunit gamma. (1159 aa)
PEX5LPeroxisomal biogenesis factor 5 like. (626 aa)
GRIK5Glutamate ionotropic receptor kainate type subunit 5. (946 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (747 aa)
AKAP6A-kinase anchoring protein 6. (2319 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
MICU2Mitochondrial calcium uptake 2. (362 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
KCNB2Potassium voltage-gated channel subfamily B member 2; Belongs to the potassium channel family. (910 aa)
KCNMB2KcnmB2_inactiv domain-containing protein. (235 aa)
CNIH3Cornichon family AMPA receptor auxiliary protein 3. (157 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1264 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1987 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (702 aa)
KCNA6Potassium voltage-gated channel subfamily A member 6; Belongs to the potassium channel family. (531 aa)
AKAP9A-kinase anchoring protein 9. (3909 aa)
MICU3Mitochondrial calcium uptake family member 3. (422 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1422 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (215 aa)
KCNG4Potassium voltage-gated channel modifier subfamily G member 4; Belongs to the potassium channel family. (519 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2005 aa)
HTR3E5-hydroxytryptamine receptor 3E; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (450 aa)
KCNIP3Potassium voltage-gated channel interacting protein 3. (256 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2080 aa)
HTR3A5-hydroxytryptamine receptor 3A; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (521 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (600 aa)
SCN4ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1836 aa)
FBXL6Uncharacterized protein. (300 aa)
SCN7ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1681 aa)
CNGA1Cyclic nucleotide gated channel subunit alpha 1. (759 aa)
PDE4BPhosphodiesterase. (736 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (954 aa)
LRRC55Leucine rich repeat containing 55. (341 aa)
VWC2Von Willebrand factor C domain containing 2. (212 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
CACNA1ACalcium voltage-gated channel subunit alpha1 A. (1985 aa)
KCNK1Potassium channel subfamily K member. (336 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (809 aa)
CACNA1BCalcium voltage-gated channel subunit alpha1 B. (2001 aa)
KCNIP2Potassium voltage-gated channel interacting protein 2. (285 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (691 aa)
CALM3Calmodulin 3. (149 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (261 aa)
ENSMLEP00000033212Uncharacterized protein. (76 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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