(40 nodes) Recognition of DNA damage by PCNA-containing replication complex network (Mandrillus leucophaeus)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	ENSMLEP00000030942	Dpoe2NT domain-containing protein. (96 aa)
	POLD4	Uncharacterized protein. (107 aa)
	POLD2	DNA polymerase delta 2, accessory subunit. (504 aa)
	WDR48	WD repeat domain 48. (677 aa)
	MEIOB	Meiosis specific with OB-fold. (407 aa)
	ENSMLEP00000034242	Uncharacterized protein. (173 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2288 aa)
	LOC105541671	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (252 aa)
	DDB1	Damage specific DNA binding protein 1. (1147 aa)
	ENSMLEP00000022706	Zf-rbx1 domain-containing protein. (93 aa)
	RBX1	RING-type domain-containing protein. (108 aa)
	RFC1	Replication factor C subunit 1. (1148 aa)
	POLD3	Uncharacterized protein. (454 aa)
	RPA3	Replication protein A3. (121 aa)
	RFC2	Replication factor C subunit 2. (352 aa)
	POLD1	DNA polymerase. (1134 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (595 aa)
	ATAD5	ATPase family AAA domain containing 5. (1834 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (138 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	RAD18	RAD18 E3 ubiquitin protein ligase. (496 aa)
	LOC105541098	Ubiquitin-like domain-containing protein. (156 aa)
	ENSMLEP00000006240	Ubiquitin-like domain-containing protein. (127 aa)
	ENSMLEP00000006951	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (268 aa)
	RCBTB2	RCC1 and BTB domain containing protein 2. (556 aa)
	RFC3	Replication factor C subunit 3. (356 aa)
	RFC4	Replication factor C subunit 4. (363 aa)
	POLE3	DNA polymerase epsilon 3, accessory subunit. (147 aa)
	DTL	Denticleless E3 ubiquitin protein ligase homolog. (730 aa)
	USP1	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (785 aa)
	CUL4A	Cullin 4A; Belongs to the cullin family. (587 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	RFC5	Replication factor C subunit 5. (340 aa)
	POLE4	DNA polymerase epsilon 4, accessory subunit. (119 aa)
	ENSMLEP00000011388	Ubiquitin-like domain-containing protein. (120 aa)
	ENSMLEP00000010931	Uncharacterized protein. (79 aa)
	CUL4B	Cullin 4B; Belongs to the cullin family. (931 aa)
	LOC105554521	DNA_pol_E_B domain-containing protein. (252 aa)
	LOC105536598	Ubiquitin-like domain-containing protein. (156 aa)
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	CUL4A	ENSMLEP00000000073	ENSMLEP00000017238	ATPase family AAA domain containing 5.	Cullin 4A; Belongs to the cullin family.	0.539
ATAD5	CUL4B	ENSMLEP00000000073	ENSMLEP00000010897	ATPase family AAA domain containing 5.	Cullin 4B; Belongs to the cullin family.	0.539
ATAD5	DDB1	ENSMLEP00000000073	ENSMLEP00000040250	ATPase family AAA domain containing 5.	Damage specific DNA binding protein 1.	0.585
ATAD5	DTL	ENSMLEP00000000073	ENSMLEP00000018121	ATPase family AAA domain containing 5.	Denticleless E3 ubiquitin protein ligase homolog.	0.874
ATAD5	ENSMLEP00000006951	ENSMLEP00000000073	ENSMLEP00000006951	ATPase family AAA domain containing 5.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.682
ATAD5	ENSMLEP00000010931	ENSMLEP00000000073	ENSMLEP00000010931	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.524
ATAD5	ENSMLEP00000030942	ENSMLEP00000000073	ENSMLEP00000030942	ATPase family AAA domain containing 5.	Dpoe2NT domain-containing protein.	0.770
ATAD5	LOC105536598	ENSMLEP00000000073	ENSMLEP00000008278	ATPase family AAA domain containing 5.	Ubiquitin-like domain-containing protein.	0.479
ATAD5	LOC105541098	ENSMLEP00000000073	ENSMLEP00000004673	ATPase family AAA domain containing 5.	Ubiquitin-like domain-containing protein.	0.479
ATAD5	LOC105541671	ENSMLEP00000000073	ENSMLEP00000036910	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.946
ATAD5	LOC105554521	ENSMLEP00000000073	ENSMLEP00000010506	ATPase family AAA domain containing 5.	DNA_pol_E_B domain-containing protein.	0.770
ATAD5	MEIOB	ENSMLEP00000000073	ENSMLEP00000022929	ATPase family AAA domain containing 5.	Meiosis specific with OB-fold.	0.682
ATAD5	PCNA	ENSMLEP00000000073	ENSMLEP00000002676	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.946
ATAD5	POLD1	ENSMLEP00000000073	ENSMLEP00000026893	ATPase family AAA domain containing 5.	DNA polymerase.	0.794
ATAD5	POLD2	ENSMLEP00000000073	ENSMLEP00000031727	ATPase family AAA domain containing 5.	DNA polymerase delta 2, accessory subunit.	0.665
ATAD5	POLE	ENSMLEP00000000073	ENSMLEP00000035885	ATPase family AAA domain containing 5.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.904
ATAD5	POLE3	ENSMLEP00000000073	ENSMLEP00000018131	ATPase family AAA domain containing 5.	DNA polymerase epsilon 3, accessory subunit.	0.744
ATAD5	POLE4	ENSMLEP00000000073	ENSMLEP00000011403	ATPase family AAA domain containing 5.	DNA polymerase epsilon 4, accessory subunit.	0.708
ATAD5	RAD18	ENSMLEP00000000073	ENSMLEP00000003335	ATPase family AAA domain containing 5.	RAD18 E3 ubiquitin protein ligase.	0.801
ATAD5	RFC1	ENSMLEP00000000073	ENSMLEP00000040611	ATPase family AAA domain containing 5.	Replication factor C subunit 1.	0.697