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PDE1A PDE1A CAMK2D CAMK2D PRKAR1A PRKAR1A GNA11 GNA11 ENSMLEP00000001951 ENSMLEP00000001951 POMC POMC THAP6 THAP6 PPP1R1B PPP1R1B ADCY4 ADCY4 GNB4 GNB4 ADCY9 ADCY9 PPP3CC PPP3CC ADCY7 ADCY7 CAMKK1 CAMKK1 ADCY8 ADCY8 GNAI2 GNAI2 ITPR2 ITPR2 GNB3 GNB3 PDE4D PDE4D THAP7 THAP7 ENSMLEP00000007417 ENSMLEP00000007417 PLCB1 PLCB1 CAMK2B CAMK2B CAMK2G CAMK2G PPP1CA PPP1CA PDYN PDYN GNG2 GNG2 LOC105550079 LOC105550079 PLCB4 PLCB4 GNAQ GNAQ ITPR1 ITPR1 PRKX PRKX PPP3CA PPP3CA LRBA LRBA LOC105532537 LOC105532537 PRKAR1B PRKAR1B PPP2R1A PPP2R1A OPRM1 OPRM1 NBEA NBEA PDE4A PDE4A GNAT3 GNAT3 PLA2G4A PLA2G4A PPP2CA PPP2CA ENSMLEP00000014682 ENSMLEP00000014682 GNA14 GNA14 ENSMLEP00000016272 ENSMLEP00000016272 ADCY2 ADCY2 GNA15 GNA15 CREB1 CREB1 CDK5 CDK5 GNB1 GNB1 PRKACA PRKACA PRKCA PRKCA GRK2 GRK2 PPP2CB PPP2CB CAMK4 CAMK4 ITPR3 ITPR3 PPP2R5D PPP2R5D GNB5 GNB5 PLCB2 PLCB2 MAPK1 MAPK1 GNB2 GNB2 ADCY1 ADCY1 PDE1C PDE1C PPP3CB PPP3CB PRKCG PRKCG ENSMLEP00000024790 ENSMLEP00000024790 ADCY5 ADCY5 GNGT2 GNGT2 GNAI3 GNAI3 ADCY3 ADCY3 PPP3R1 PPP3R1 ENSMLEP00000028401 ENSMLEP00000028401 GNG12 GNG12 KPNA2 KPNA2 GNG5 GNG5 GNG3 GNG3 PRKAR2A PRKAR2A GNG4 GNG4 PDE4B PDE4B CAMK2A CAMK2A PRKAR2B PRKAR2B PRKACB PRKACB GNGT1 GNGT1 GNAI1 GNAI1 PRKCD PRKCD CNBD2 CNBD2 GNG8 GNG8 DCLK1 DCLK1 GNG13 GNG13 ADCY6 ADCY6 GNAL GNAL AHCYL1 AHCYL1 PPP2R1B PPP2R1B ENSMLEP00000038778 ENSMLEP00000038778 PDE4C PDE4C PDE1B PDE1B PLCB3 PLCB3 CAMKK2 CAMKK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDE1APhosphodiesterase. (545 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (441 aa)
PRKAR1AUncharacterized protein. (381 aa)
GNA11G protein subunit alpha 11. (307 aa)
ENSMLEP00000001951Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (60 aa)
POMCProopiomelanocortin. (265 aa)
THAP6THAP domain containing 6. (221 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (204 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
GNB4G protein subunit beta 4. (340 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PPP3CCSerine/threonine-protein phosphatase. (438 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
CAMKK1Calcium/calmodulin dependent protein kinase kinase 1. (532 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
GNAI2G protein subunit alpha i2. (352 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2663 aa)
GNB3G protein subunit beta 3. (340 aa)
PDE4DPhosphodiesterase. (748 aa)
THAP7THAP domain containing 7. (309 aa)
ENSMLEP00000007417Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (689 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (546 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (355 aa)
PDYNProdynorphin. (253 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
LOC105550079Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1165 aa)
GNAQG protein subunit alpha q. (313 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2731 aa)
PRKXProtein kinase X-linked. (304 aa)
PPP3CASerine/threonine-protein phosphatase. (501 aa)
LRBALPS responsive beige-like anchor protein. (2852 aa)
LOC105532537Importin subunit alpha; Functions in nuclear protein import. (510 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
OPRM1Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (485 aa)
NBEANeurobeachin. (2651 aa)
PDE4APhosphodiesterase 4A; Belongs to the cyclic nucleotide phosphodiesterase family. (766 aa)
GNAT3G protein subunit alpha transducin 3. (354 aa)
PLA2G4APhospholipase A2. (749 aa)
PPP2CASerine/threonine-protein phosphatase. (275 aa)
ENSMLEP00000014682IBB domain-containing protein. (407 aa)
GNA14G protein subunit alpha 14. (355 aa)
ENSMLEP00000016272Uncharacterized protein. (374 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (901 aa)
GNA15G protein subunit alpha 15. (374 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (302 aa)
GNB1G protein subunit beta 1. (340 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (701 aa)
PPP2CBSerine/threonine-protein phosphatase. (275 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2675 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (605 aa)
GNB5G protein subunit beta 5. (357 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1089 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
GNB2G protein subunit beta 2. (340 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
PDE1CPhosphodiesterase. (768 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
PRKCGProtein kinase C gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (558 aa)
ENSMLEP00000024790Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (294 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1064 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
PPP3R1Uncharacterized protein. (189 aa)
ENSMLEP00000028401Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (65 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
KPNA2Importin subunit alpha; Functions in nuclear protein import. (529 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PRKAR2AUncharacterized protein. (211 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PDE4BPhosphodiesterase. (736 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (378 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNAI1G protein subunit alpha i1. (314 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
CNBD2Cyclic nucleotide binding domain containing 2. (577 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
DCLK1Doublecortin like kinase 1. (740 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
GNALG protein subunit alpha L. (309 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (509 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (637 aa)
ENSMLEP00000038778Uncharacterized protein. (300 aa)
PDE4CPhosphodiesterase. (612 aa)
PDE1BPhosphodiesterase. (538 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (588 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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