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ATP8 ATP8 MT-ATP6 MT-ATP6 TFB1M TFB1M APOOL APOOL ENSMLEP00000000596 ENSMLEP00000000596 MTX2 MTX2 MTERF2 MTERF2 CREBBP CREBBP ATP5F1D ATP5F1D LOC105538825 LOC105538825 LOC105553918 LOC105553918 ENSMLEP00000001615 ENSMLEP00000001615 CARM1 CARM1 LOC105553485 LOC105553485 ENSMLEP00000001820 ENSMLEP00000001820 MTERF1 MTERF1 LOC105543108 LOC105543108 MICOS10 MICOS10 PRKAA2 PRKAA2 ATP5PF ATP5PF LOC105537959 LOC105537959 LOC105532116 LOC105532116 CRTC3 CRTC3 PRKAB1 PRKAB1 NCOA6 NCOA6 LOC105533249 LOC105533249 ATP5MC1 ATP5MC1 IMMT IMMT ENSMLEP00000006670 ENSMLEP00000006670 ENSMLEP00000006706 ENSMLEP00000006706 ENSMLEP00000007765 ENSMLEP00000007765 LOC105550227 LOC105550227 PRKAG3 PRKAG3 TWNK TWNK CHCHD6 CHCHD6 RXRA RXRA ATP5PD ATP5PD GABPA GABPA MICOS13 MICOS13 GABPB1 GABPB1 ENSMLEP00000013928 ENSMLEP00000013928 ENSMLEP00000014083 ENSMLEP00000014083 ENSMLEP00000014201 ENSMLEP00000014201 SOD2 SOD2 DMAC2L DMAC2L TFB2M TFB2M TFAM TFAM DNAJC11 DNAJC11 TBL1XR1 TBL1XR1 ACSS2 ACSS2 ATP5F1E ATP5F1E ALAS1 ALAS1 CRTC2 CRTC2 LOC105555392 LOC105555392 NCOA1 NCOA1 ATP5F1C ATP5F1C ENSMLEP00000019156 ENSMLEP00000019156 GLUD2 GLUD2 CREB1 CREB1 NCOR1 NCOR1 IDH2 IDH2 PPARGC1A PPARGC1A HELZ2 HELZ2 NCOA2 NCOA2 ATP5F1B ATP5F1B TGS1 TGS1 PPARA PPARA CAMK4 CAMK4 MEF2C MEF2C ATF2 ATF2 ATP5MC2 ATP5MC2 ENSMLEP00000022839 ENSMLEP00000022839 ENSMLEP00000023092 ENSMLEP00000023092 ENSMLEP00000023115 ENSMLEP00000023115 MAPK11 MAPK11 ESRRA ESRRA SIRT5 SIRT5 ENSMLEP00000024203 ENSMLEP00000024203 APOO APOO TBL1X TBL1X NR1D1 NR1D1 ENSMLEP00000025686 ENSMLEP00000025686 LOC105548856 LOC105548856 SIRT3 SIRT3 POLRMT POLRMT SAMM50 SAMM50 PRKAG2 PRKAG2 MAPK12 MAPK12 HDAC3 HDAC3 MED1 MED1 SRFBP1 SRFBP1 ENSMLEP00000028979 ENSMLEP00000028979 ENSMLEP00000030121 ENSMLEP00000030121 CHCHD3 CHCHD3 ENSMLEP00000030425 ENSMLEP00000030425 POLG2 POLG2 SSBP1 SSBP1 LOC105544867 LOC105544867 SMARCD3 SMARCD3 ATP5PO ATP5PO ENSMLEP00000031861 ENSMLEP00000031861 ENSMLEP00000031946 ENSMLEP00000031946 ENSMLEP00000032887 ENSMLEP00000032887 PRKAG1 PRKAG1 PPARGC1B PPARGC1B PRKAB2 PRKAB2 LOC105547964 LOC105547964 ENSMLEP00000035471 ENSMLEP00000035471 ATP5MG ATP5MG HCFC1 HCFC1 ATP5PB ATP5PB TMEM11 TMEM11 LOC105529405 LOC105529405 C17orf80 C17orf80 MEF2D MEF2D CHD9 CHD9 MAPK14 MAPK14 LOC105553592 LOC105553592 LOC105547344 LOC105547344 ATP5MC3 ATP5MC3 GABPB2 GABPB2 SIRT4 SIRT4 ATP5ME ATP5ME CRTC1 CRTC1 NRF1 NRF1 HSPA9 HSPA9
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATP8ATP synthase protein 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (66 aa)
MT-ATP6ATP synthase subunit a. (226 aa)
TFB1MrRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (345 aa)
APOOLMICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (277 aa)
ENSMLEP00000000596MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (227 aa)
MTX2Metaxin 2. (263 aa)
MTERF2Mitochondrial transcription termination factor 2. (385 aa)
CREBBPCREB binding protein. (2423 aa)
ATP5F1DATP synthase F1 subunit delta. (154 aa)
LOC105538825Uncharacterized protein. (88 aa)
LOC105553918Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSMLEP00000001615Uncharacterized protein. (368 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (534 aa)
LOC105553485Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSMLEP00000001820Uncharacterized protein. (260 aa)
MTERF1Mitochondrial transcription termination factor 1. (399 aa)
LOC105543108ATP synthase subunit; Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proto [...] (103 aa)
MICOS10MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (78 aa)
PRKAA2Non-specific serine/threonine protein kinase. (542 aa)
ATP5PFATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain; Belongs to the eukaryotic ATPase subunit F6 family. (119 aa)
LOC105537959ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (161 aa)
LOC105532116MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (277 aa)
CRTC3CREB regulated transcription coactivator 3. (596 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
NCOA6Nuclear receptor coactivator 6. (2066 aa)
LOC105533249Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa)
ATP5MC1ATP synthase membrane subunit c locus 1; Belongs to the ATPase C chain family. (135 aa)
IMMTMICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (758 aa)
ENSMLEP00000006670Uncharacterized protein. (422 aa)
ENSMLEP00000006706Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (96 aa)
ENSMLEP00000007765Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC105550227Uncharacterized protein. (213 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
TWNKTwinkle mtDNA helicase. (582 aa)
CHCHD6MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (256 aa)
RXRARetinoid X receptor alpha. (452 aa)
ATP5PDATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (161 aa)
GABPAGA binding protein transcription factor subunit alpha. (454 aa)
MICOS13MICOS complex subunit MIC13; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (134 aa)
GABPB1GA binding protein transcription factor subunit beta 1. (395 aa)
ENSMLEP00000013928Uncharacterized protein. (91 aa)
ENSMLEP00000014083Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (86 aa)
ENSMLEP00000014201Uncharacterized protein. (478 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (236 aa)
DMAC2LDistal membrane arm assembly complex 2 like. (164 aa)
TFB2MrRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (396 aa)
TFAMTranscription factor A, mitochondrial. (248 aa)
DNAJC11DnaJ heat shock protein family (Hsp40) member C11. (546 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (514 aa)
ACSS2Acyl-CoA synthetase short chain family member 2. (714 aa)
ATP5F1EATP synthase F1 subunit epsilon. (51 aa)
ALAS15-aminolevulinate synthase. (640 aa)
CRTC2CREB regulated transcription coactivator 2. (694 aa)
LOC105555392Uncharacterized protein. (428 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
ATP5F1CATP synthase subunit gamma. (298 aa)
ENSMLEP00000019156Uncharacterized protein. (62 aa)
GLUD2Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (522 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
NCOR1Nuclear receptor corepressor 1. (2404 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (460 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
HELZ2Helicase with zinc finger 2. (2615 aa)
NCOA2Nuclear receptor coactivator. (1468 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (529 aa)
TGS1Trimethylguanosine synthase 1. (855 aa)
PPARAPeroxisome proliferator activated receptor alpha. (365 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ATP5MC2ATP synthase membrane subunit c locus 2; Belongs to the ATPase C chain family. (198 aa)
ENSMLEP00000022839ATP-synt_C domain-containing protein; Belongs to the ATPase C chain family. (163 aa)
ENSMLEP00000023092Uncharacterized protein; Belongs to the ATPase C chain family. (119 aa)
ENSMLEP00000023115Uncharacterized protein; Belongs to the ATPase C chain family. (127 aa)
MAPK11Mitogen-activated protein kinase. (224 aa)
ESRRAEstrogen related receptor alpha. (422 aa)
SIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (310 aa)
ENSMLEP00000024203Uncharacterized protein. (97 aa)
APOOMICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (198 aa)
TBL1XTransducin beta like 1 X-linked. (573 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
ENSMLEP00000025686Uncharacterized protein. (95 aa)
LOC105548856Uncharacterized protein; Belongs to the heat shock protein 70 family. (591 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (340 aa)
POLRMTDNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family. (1074 aa)
SAMM50SAMM50 sorting and assembly machinery component. (497 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (506 aa)
MAPK12Mitogen-activated protein kinase. (292 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1575 aa)
SRFBP1Serum response factor binding protein 1. (368 aa)
ENSMLEP00000028979Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (99 aa)
ENSMLEP00000030121Uncharacterized protein. (143 aa)
CHCHD3MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (237 aa)
ENSMLEP00000030425ATP-synt_C domain-containing protein; Belongs to the ATPase C chain family. (118 aa)
POLG2DNA polymerase gamma 2, accessory subunit. (485 aa)
SSBP1Single stranded DNA binding protein 1. (148 aa)
LOC105544867Uncharacterized protein. (119 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
ATP5POUncharacterized protein. (213 aa)
ENSMLEP00000031861Uncharacterized protein. (89 aa)
ENSMLEP00000031946ATP-synt_C domain-containing protein; Belongs to the ATPase C chain family. (165 aa)
ENSMLEP00000032887MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (205 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (326 aa)
PPARGC1BPPARG coactivator 1 beta. (997 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
LOC105547964Uncharacterized protein. (214 aa)
ENSMLEP00000035471Uncharacterized protein. (92 aa)
ATP5MGATP synthase subunit; Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proto [...] (103 aa)
HCFC1Host cell factor C1. (2080 aa)
ATP5PBUncharacterized protein. (256 aa)
TMEM11Transmembrane protein 11. (192 aa)
LOC105529405Uncharacterized protein. (101 aa)
C17orf80Chromosome 17 open reading frame 80. (609 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
CHD9Chromodomain helicase DNA binding protein 9. (2901 aa)
MAPK14Mitogen-activated protein kinase. (350 aa)
LOC105553592Uncharacterized protein. (231 aa)
LOC105547344ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (264 aa)
ATP5MC3ATP synthase membrane subunit c locus 3; Belongs to the ATPase C chain family. (141 aa)
GABPB2GA binding protein transcription factor subunit beta 2. (448 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
ATP5MEATP synthase membrane subunit e. (57 aa)
CRTC1CREB regulated transcription coactivator 1. (570 aa)
NRF1Nuclear respiratory factor 1. (522 aa)
HSPA9Uncharacterized protein; Belongs to the heat shock protein 70 family. (679 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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