STRINGSTRING
PRKAR1A PRKAR1A KCNC2 KCNC2 GNA11 GNA11 MLX MLX ABCC8 ABCC8 KCNJ11 KCNJ11 ENSMLEP00000001951 ENSMLEP00000001951 VAMP2 VAMP2 FFAR1 FFAR1 ENSMLEP00000002280 ENSMLEP00000002280 THAP6 THAP6 ADCY4 ADCY4 GNB4 GNB4 ADCY9 ADCY9 ADCY7 ADCY7 PRKAA2 PRKAA2 SLC2A1 SLC2A1 GNAS GNAS SYT5 SYT5 CACNB3 CACNB3 TKTL2 TKTL2 ADCY8 ADCY8 KCNS3 KCNS3 MLXIP MLXIP GNAI2 GNAI2 ITPR2 ITPR2 GNB3 GNB3 THAP7 THAP7 FASN FASN ENSMLEP00000007417 ENSMLEP00000007417 PLCB1 PLCB1 ACACA ACACA RAP1A RAP1A RAPGEFL1 RAPGEFL1 ENSMLEP00000008990 ENSMLEP00000008990 GNG2 GNG2 LOC105550079 LOC105550079 GNAQ GNAQ ITPR1 ITPR1 PRKAR1B PRKAR1B PPP2R1A PPP2R1A CD36 CD36 PPP2CA PPP2CA TKTL1 TKTL1 GNA14 GNA14 ACSL3 ACSL3 FAP FAP INS INS ENSMLEP00000016272 ENSMLEP00000016272 ADCY2 ADCY2 ADIPOR2 ADIPOR2 CACNA2D2 CACNA2D2 CACNB2 CACNB2 ADIPOQ ADIPOQ GNA15 GNA15 CACNA1D CACNA1D GNB1 GNB1 CACNA1E CACNA1E PRKACA PRKACA PRKCA PRKCA PPP2CB PPP2CB ADRA2A ADRA2A CACNA1F CACNA1F ITPR3 ITPR3 PPP2R5D PPP2R5D GNB5 GNB5 GCG GCG PLCB2 PLCB2 GNB2 GNB2 ADCY1 ADCY1 SLC2A2 SLC2A2 ENSMLEP00000024790 ENSMLEP00000024790 ADCY5 ADCY5 GNGT2 GNGT2 STXBP1 STXBP1 GCGR GCGR CACNA1C CACNA1C ADCY3 ADCY3 PRKAG2 PRKAG2 STK11 STK11 TKT TKT ENSMLEP00000028401 ENSMLEP00000028401 MLXIPL MLXIPL GNG12 GNG12 GNG5 GNG5 GNG3 GNG3 TALDO1 TALDO1 PRKAR2A PRKAR2A GNG4 GNG4 CACNA1A CACNA1A PFKFB1 PFKFB1 PRKAR2B PRKAR2B PRKACB PRKACB GLP1R GLP1R SNAP25 SNAP25 ADIPOR1 ADIPOR1 AGPAT1 AGPAT1 GNGT1 GNGT1 PRKAB2 PRKAB2 STX1A STX1A ACSL4 ACSL4 ADRA2C ADRA2C RAPGEF3 RAPGEF3 CNBD2 CNBD2 GNG8 GNG8 RAPGEF5 RAPGEF5 IQGAP1 IQGAP1 CACNA2D1 CACNA2D1 GNG13 GNG13 ADCY6 ADCY6 RAPGEF4 RAPGEF4 AHCYL1 AHCYL1 PPP2R1B PPP2R1B PLCB3 PLCB3 ACLY ACLY
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKAR1AUncharacterized protein. (381 aa)
KCNC2Potassium voltage-gated channel subfamily C member 2; Belongs to the potassium channel family. (638 aa)
GNA11G protein subunit alpha 11. (307 aa)
MLXMAX dimerization protein MLX. (298 aa)
ABCC8ATP binding cassette subfamily C member 8. (1582 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
ENSMLEP00000001951Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (60 aa)
VAMP2V-SNARE coiled-coil homology domain-containing protein. (118 aa)
FFAR1Free fatty acid receptor 1. (300 aa)
ENSMLEP00000002280Biotin carboxylation domain-containing protein. (205 aa)
THAP6THAP domain containing 6. (221 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
GNB4G protein subunit beta 4. (340 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
PRKAA2Non-specific serine/threonine protein kinase. (542 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (506 aa)
GNASGNAS complex locus. (998 aa)
SYT5Synaptotagmin 5. (386 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
TKTL2Transketolase like 2. (626 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
KCNS3Potassium voltage-gated channel modifier subfamily S member 3; Belongs to the potassium channel family. (491 aa)
MLXIPMLX interacting protein. (856 aa)
GNAI2G protein subunit alpha i2. (352 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2663 aa)
GNB3G protein subunit beta 3. (340 aa)
THAP7THAP domain containing 7. (309 aa)
FASNFatty acid synthase. (2510 aa)
ENSMLEP00000007417Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
ACACAAcetyl-CoA carboxylase alpha. (2383 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
RAPGEFL1Rap guanine nucleotide exchange factor like 1. (663 aa)
ENSMLEP00000008990Uncharacterized protein. (858 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (110 aa)
LOC105550079Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNAQG protein subunit alpha q. (313 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2731 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
PPP2CASerine/threonine-protein phosphatase. (275 aa)
TKTL1Transketolase like 1. (596 aa)
GNA14G protein subunit alpha 14. (355 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ENSMLEP00000016272Uncharacterized protein. (374 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (901 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1081 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (249 aa)
GNA15G protein subunit alpha 15. (374 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
GNB1G protein subunit beta 1. (340 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2315 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (352 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
PPP2CBSerine/threonine-protein phosphatase. (275 aa)
ADRA2AAdrenoceptor alpha 2A. (310 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1960 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2675 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (605 aa)
GNB5G protein subunit beta 5. (357 aa)
GCGGlucagon. (180 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1089 aa)
GNB2G protein subunit beta 2. (340 aa)
ADCY1Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (338 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (525 aa)
ENSMLEP00000024790Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (294 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1064 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
STXBP1Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (597 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (491 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2169 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (506 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
TKTTransketolase. (597 aa)
ENSMLEP00000028401Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (65 aa)
MLXIPLMLX interacting protein like. (784 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
TALDO1Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (314 aa)
PRKAR2AUncharacterized protein. (211 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CACNA1ACalcium voltage-gated channel subunit alpha1 A. (1985 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (471 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (378 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (283 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
STX1ASyntaxin 1A; Belongs to the syntaxin family. (288 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (670 aa)
ADRA2CAdrenoceptor alpha 2C. (302 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (925 aa)
CNBD2Cyclic nucleotide binding domain containing 2. (577 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
RAPGEF5Rap guanine nucleotide exchange factor 5. (730 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1639 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1018 aa)
GNG13Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (989 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (509 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (637 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
ACLYATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1101 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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