(24 nodes) Synthesis, secretion, and deacylation of Ghrelin network (Mandrillus leucophaeus)

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second shell of interactors

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Known Interactions

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Predicted Interactions

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Your Input:
	GHRL	Ghrelin and obestatin prepropeptide. (117 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	ENSMLEP00000036527	Uncharacterized protein. (89 aa)
	SEC11C	Signal peptidase complex catalytic subunit SEC11. (192 aa)
	CRHR2	Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (431 aa)
	BCHE	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (602 aa)
	ACHE	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (631 aa)
	LOC105551725	Uncharacterized protein. (217 aa)
	PLA2G7	Platelet-activating factor acetylhydrolase. (440 aa)
	IGF1	Insulin like growth factor 1. (159 aa)
	LOC105552429	Signal peptidase complex catalytic subunit SEC11. (168 aa)
	MBOAT4	Membrane bound O-acyltransferase domain containing 4; Belongs to the membrane-bound acyltransferase family. (435 aa)
	ENSMLEP00000010804	Uncharacterized protein. (213 aa)
	ENSMLEP00000011373	Uncharacterized protein. (213 aa)
	KLF4	Uncharacterized protein. (145 aa)
	SPCS1	Signal peptidase complex subunit 1. (169 aa)
	FAP	Fibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	PCSK1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (749 aa)
	SEC11A	Signal peptidase complex catalytic subunit SEC11. (185 aa)
	LOC105551727	Uncharacterized protein. (160 aa)
	GCG	Glucagon. (180 aa)
	SPCS3	Signal peptidase complex subunit 3. (180 aa)
	SPCS2	Signal peptidase complex subunit 2. (257 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACHE	GHRL	ENSMLEP00000002950	ENSMLEP00000029313	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Ghrelin and obestatin prepropeptide.	0.613
BCHE	GHRL	ENSMLEP00000000994	ENSMLEP00000029313	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	Ghrelin and obestatin prepropeptide.	0.653
CRHR2	GHRL	ENSMLEP00000039151	ENSMLEP00000029313	Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family.	Ghrelin and obestatin prepropeptide.	0.428
ENSMLEP00000010804	LOC105552429	ENSMLEP00000010804	ENSMLEP00000008914	Uncharacterized protein.	Signal peptidase complex catalytic subunit SEC11.	0.939
ENSMLEP00000010804	SEC11A	ENSMLEP00000010804	ENSMLEP00000019440	Uncharacterized protein.	Signal peptidase complex catalytic subunit SEC11.	0.904
ENSMLEP00000010804	SEC11C	ENSMLEP00000010804	ENSMLEP00000036616	Uncharacterized protein.	Signal peptidase complex catalytic subunit SEC11.	0.939
ENSMLEP00000010804	SPCS1	ENSMLEP00000010804	ENSMLEP00000012666	Uncharacterized protein.	Signal peptidase complex subunit 1.	0.981
ENSMLEP00000010804	SPCS3	ENSMLEP00000010804	ENSMLEP00000023210	Uncharacterized protein.	Signal peptidase complex subunit 3.	0.976
ENSMLEP00000011373	LOC105552429	ENSMLEP00000011373	ENSMLEP00000008914	Uncharacterized protein.	Signal peptidase complex catalytic subunit SEC11.	0.922
ENSMLEP00000011373	SEC11A	ENSMLEP00000011373	ENSMLEP00000019440	Uncharacterized protein.	Signal peptidase complex catalytic subunit SEC11.	0.896
ENSMLEP00000011373	SEC11C	ENSMLEP00000011373	ENSMLEP00000036616	Uncharacterized protein.	Signal peptidase complex catalytic subunit SEC11.	0.922
ENSMLEP00000011373	SPCS1	ENSMLEP00000011373	ENSMLEP00000012666	Uncharacterized protein.	Signal peptidase complex subunit 1.	0.971
ENSMLEP00000011373	SPCS3	ENSMLEP00000011373	ENSMLEP00000023210	Uncharacterized protein.	Signal peptidase complex subunit 3.	0.971
FAP	GCG	ENSMLEP00000016090	ENSMLEP00000022616	Fibroblast activation protein alpha; Belongs to the peptidase S9B family.	Glucagon.	0.555
FAP	GHRL	ENSMLEP00000016090	ENSMLEP00000029313	Fibroblast activation protein alpha; Belongs to the peptidase S9B family.	Ghrelin and obestatin prepropeptide.	0.724
FAP	INS	ENSMLEP00000016090	ENSMLEP00000016207	Fibroblast activation protein alpha; Belongs to the peptidase S9B family.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.527
FAP	LEP	ENSMLEP00000016090	ENSMLEP00000034585	Fibroblast activation protein alpha; Belongs to the peptidase S9B family.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.672
FAP	LOC105552429	ENSMLEP00000016090	ENSMLEP00000008914	Fibroblast activation protein alpha; Belongs to the peptidase S9B family.	Signal peptidase complex catalytic subunit SEC11.	0.493
FAP	PCSK1	ENSMLEP00000016090	ENSMLEP00000018983	Fibroblast activation protein alpha; Belongs to the peptidase S9B family.	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.563
FAP	SEC11A	ENSMLEP00000016090	ENSMLEP00000019440	Fibroblast activation protein alpha; Belongs to the peptidase S9B family.	Signal peptidase complex catalytic subunit SEC11.	0.493