(64 nodes) Recycling pathway of L1 network (Mandrillus leucophaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AP2A1	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (912 aa)
	ACTL8	Actin like 8; Belongs to the actin family. (366 aa)
	ACTL7B	Actin like 7B; Belongs to the actin family. (415 aa)
	TUBB4B	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (373 aa)
	ACTRT2	Actin related protein T2; Belongs to the actin family. (377 aa)
	DNM3	Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
	RPS6KA6	Ribosomal protein S6 kinase. (744 aa)
	RPS6KA2	Ribosomal protein S6 kinase. (728 aa)
	NUMB	NUMB endocytic adaptor protein. (652 aa)
	ACTRT1	Actin related protein T1; Belongs to the actin family. (375 aa)
	LOC105544901	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
	ACTL7A	Actin like 7A; Belongs to the actin family. (435 aa)
	EZR	Ezrin. (588 aa)
	KIF4A	Kinesin family member 4A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1227 aa)
	TUBA4A	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
	LOC105553882	Uncharacterized protein. (356 aa)
	AP2A2	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (939 aa)
	RPS6KA4	Ribosomal protein S6 kinase. (772 aa)
	CLTC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1679 aa)
	LOC105544902	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
	VSIG10L2	V-set and immunoglobulin domain containing 10 like 2. (767 aa)
	DNM2	Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (810 aa)
	FNDC3B	Fibronectin type III domain containing 3B. (1206 aa)
	FNDC3A	Fibronectin type III domain containing 3A. (1198 aa)
	DNM1	Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (797 aa)
	TUBB2A	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (438 aa)
	LOC105540399	Uncharacterized protein; Belongs to the actin family. (362 aa)
	RPS6KA3	Ribosomal protein S6 kinase. (742 aa)
	SH3GL2	SH3 domain containing GRB2 like 2, endophilin A1. (357 aa)
	AP2S1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
	ENSMLEP00000020129	Tubulin_C domain-containing protein. (132 aa)
	CLHC1	Clathrin heavy chain linker domain-containing protein 1. (526 aa)
	SHTN1	Shootin 1. (636 aa)
	ENSMLEP00000021441	FERM domain-containing protein. (478 aa)
	CLTA	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
	LOC105551099	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
	MAPK1	Mitogen-activated protein kinase. (343 aa)
	TUBB6	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (390 aa)
	L1CAM	L1 cell adhesion molecule. (1257 aa)
	ENSMLEP00000024944	Tubulin domain-containing protein. (119 aa)
	ENSMLEP00000025432	B2-adapt-app_C domain-containing protein. (224 aa)
	MSN	Moesin. (581 aa)
	AP2M1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (458 aa)
	TUBB	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
	TUBAL3	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
	TUBB1	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
	ENSMLEP00000027131	Uncharacterized protein. (130 aa)
	RPS6KA5	Ribosomal protein S6 kinase. (801 aa)
	TUBA1C	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (489 aa)
	TUBA8	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (467 aa)
	RPS6KA1	Ribosomal protein S6 kinase. (744 aa)
	ACTG1	Actin gamma 1. (376 aa)
	AP2B1	AP complex subunit beta. (942 aa)
	LOC105538796	Tubulin domain-containing protein. (92 aa)
	DPYSL2	Dihydropyrimidinase like 2. (677 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	LOC105543301	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (344 aa)
	HMCN1	Hemicentin 1. (5385 aa)
	VSIG10L	V-set and immunoglobulin domain containing 10 like. (702 aa)
	LOC105532182	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
	HMCN2	Hemicentin 2. (4877 aa)
	ACTB	Actin beta. (375 aa)
	LOC105554872	Tubulin domain-containing protein; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (327 aa)
	TUBB2B	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)

Your Current Organism:

Mandrillus leucophaeus

NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ACTG1	ENSMLEP00000029448	ENSMLEP00000036637	Actin beta.	Actin gamma 1.	0.547
ACTB	ENSMLEP00000021441	ENSMLEP00000029448	ENSMLEP00000021441	Actin beta.	FERM domain-containing protein.	0.762
ACTB	EZR	ENSMLEP00000029448	ENSMLEP00000007290	Actin beta.	Ezrin.	0.923
ACTB	LOC105532182	ENSMLEP00000029448	ENSMLEP00000031976	Actin beta.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.435
ACTB	LOC105538796	ENSMLEP00000029448	ENSMLEP00000035857	Actin beta.	Tubulin domain-containing protein.	0.425
ACTB	LOC105544901	ENSMLEP00000029448	ENSMLEP00000006255	Actin beta.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.444
ACTB	LOC105544902	ENSMLEP00000029448	ENSMLEP00000013723	Actin beta.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.435
ACTB	LOC105551099	ENSMLEP00000029448	ENSMLEP00000022729	Actin beta.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.435
ACTB	MSN	ENSMLEP00000029448	ENSMLEP00000025470	Actin beta.	Moesin.	0.913
ACTB	TUBA1C	ENSMLEP00000029448	ENSMLEP00000039124	Actin beta.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.523
ACTB	TUBA4A	ENSMLEP00000029448	ENSMLEP00000011156	Actin beta.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.521
ACTB	TUBA8	ENSMLEP00000029448	ENSMLEP00000038842	Actin beta.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.444
ACTB	TUBAL3	ENSMLEP00000029448	ENSMLEP00000026874	Actin beta.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.467
ACTB	TUBB6	ENSMLEP00000029448	ENSMLEP00000024194	Actin beta.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	0.409
ACTG1	ACTB	ENSMLEP00000036637	ENSMLEP00000029448	Actin gamma 1.	Actin beta.	0.547
ACTG1	ENSMLEP00000021441	ENSMLEP00000036637	ENSMLEP00000021441	Actin gamma 1.	FERM domain-containing protein.	0.581
ACTG1	LOC105532182	ENSMLEP00000036637	ENSMLEP00000031976	Actin gamma 1.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.434
ACTG1	LOC105544901	ENSMLEP00000036637	ENSMLEP00000006255	Actin gamma 1.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.444
ACTG1	LOC105544902	ENSMLEP00000036637	ENSMLEP00000013723	Actin gamma 1.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.434
ACTG1	LOC105551099	ENSMLEP00000036637	ENSMLEP00000022729	Actin gamma 1.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.434