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| | ENSMLEP00000040613 | Protein kinase domain-containing protein. (286 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (620 aa) |
| | HIPK2 | Homeodomain interacting protein kinase 2. (1196 aa) |
| | MAPKAP1 | MAPK associated protein 1. (522 aa) |
| | TAF3 | TATA-box binding protein associated factor 3. (868 aa) |
| | POU4F1 | POU domain protein. (255 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1312 aa) |
| | SUPT16H | SPT16 homolog, facilitates chromatin remodeling subunit. (1003 aa) |
| | TP53INP2 | Tumor protein p53 inducible nuclear protein 2. (220 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa) |
| | PPP2R1B | Protein phosphatase 2 scaffold subunit Abeta. (637 aa) |
| | CDK1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (350 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) |
| | PWWP2A | PWWP domain containing 2A. (755 aa) |
| | BANP | BTG3 associated nuclear protein. (516 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (497 aa) |
| | TP53RK | TP53 regulating kinase. (253 aa) |
| | CSNK2B | Uncharacterized protein. (298 aa) |
| | ENSMLEP00000035797 | Uncharacterized protein. (235 aa) |
| | TP53BP2 | Tumor protein p53 binding protein 2. (1131 aa) |
| | LOC105548097 | WD_REPEATS_REGION domain-containing protein. (401 aa) |
| | EHMT2 | Euchromatic histone lysine methyltransferase 2. (1266 aa) |
| | SSRP1 | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (709 aa) |
| | BRD1 | Bromodomain containing 1. (1058 aa) |
| | TAF4 | TATA-box binding protein associated factor 4. (635 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (268 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (559 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | RFFL | Ring finger and FYVE like domain containing E3 ubiquitin protein ligase. (363 aa) |
| | ENSMLEP00000034242 | Uncharacterized protein. (173 aa) |
| | ATRIP | ATR interacting protein. (772 aa) |
| | BRD7 | Bromo domain-containing protein. (645 aa) |
| | HIPK1 | Homeodomain interacting protein kinase 1. (1210 aa) |
| | PRKAB2 | Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa) |
| | PLK3 | Serine/threonine-protein kinase PLK. (626 aa) |
| | TBPL1 | TATA-box binding protein like 1. (186 aa) |
| | NUAK2 | NUAK family kinase 2. (672 aa) |
| | RNF34 | Ring finger protein 34. (377 aa) |
| | PRKAG1 | Protein kinase AMP-activated non-catalytic subunit gamma 1. (326 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa) |
| | GATAD2A | P66_CC domain-containing protein. (545 aa) |
| | NUAK1 | NUAK family kinase 1. (656 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1527 aa) |
| | EP300 | E1A binding protein p300. (2411 aa) |
| | TDRD3 | Tudor domain-containing protein. (405 aa) |
| | BRPF1 | Bromodomain and PHD finger containing 1. (1220 aa) |
| | PRR5 | Proline rich 5. (384 aa) |
| | L3MBTL4 | L3MBTL histone methyl-lysine binding protein 4. (623 aa) |
| | ZNF385C | Zinc finger protein 385C. (500 aa) |
| | AURKB | Aurora kinase B; Belongs to the protein kinase superfamily. (345 aa) |
| | TAF13 | Uncharacterized protein. (86 aa) |
| | CHD5 | Chromodomain helicase DNA binding protein 5. (1959 aa) |
| | MLST8 | MTOR associated protein, LST8 homolog. (335 aa) |
| | GATAD2B | GATA zinc finger domain containing 2B. (593 aa) |
| | RBBP4 | WD_REPEATS_REGION domain-containing protein. (432 aa) |
| | MAPKAPK5 | MAPK activated protein kinase 5. (471 aa) |
| | UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa) |
| | ENSMLEP00000029122 | Uncharacterized protein. (159 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (595 aa) |
| | MBD3 | Methyl-CpG binding domain protein 3. (254 aa) |
| | L3MBTL1 | Uncharacterized protein. (839 aa) |
| | CCNG1 | Cyclin G1; Belongs to the cyclin family. (295 aa) |
| | USP2 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (605 aa) |
| | WRN | WRN RecQ like helicase. (1404 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase. (432 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (465 aa) |
| | PIN1 | Peptidyl-prolyl cis-trans isomerase. (163 aa) |
| | L3MBTL3 | L3MBTL histone methyl-lysine binding protein 3. (780 aa) |
| | LOC105529488 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (458 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa) |
| | CSNK2A1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa) |
| | PRKAG2 | Protein kinase AMP-activated non-catalytic subunit gamma 2. (506 aa) |
| | TAF2 | TATA-box binding protein associated factor 2. (1152 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1247 aa) |
| | EXO1 | Exonuclease 1. (752 aa) |
| | TAF7L | TATA-box binding protein associated factor 7 like. (464 aa) |
| | RICTOR | RPTOR independent companion of MTOR complex 2. (1699 aa) |
| | DYRK2 | Dual specificity tyrosine phosphorylation regulated kinase 2. (604 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | ENSMLEP00000024108 | Bromo domain-containing protein. (540 aa) |
| | ENSMLEP00000023788 | RMI1_N domain-containing protein. (122 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (2965 aa) |
| | RECQL4 | RecQ like helicase 4. (1144 aa) |
| | ENSMLEP00000023688 | Uncharacterized protein. (250 aa) |
| | PIP4K2C | Phosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (421 aa) |
| | DYRK3 | Dual specificity tyrosine phosphorylation regulated kinase 3. (588 aa) |
| | PRMT5 | Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (620 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (224 aa) |
| | MEIOB | Meiosis specific with OB-fold. (407 aa) |
| | USP7 | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1116 aa) |
| | POU4F3 | POU domain protein. (338 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | CHEK1 | Checkpoint kinase 1. (480 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (275 aa) |
| | TAF1 | Transcription initiation factor TFIID subunit. (1881 aa) |
| | ING5 | Inhibitor of growth family member 5. (253 aa) |
| | TPX2 | TPX2 microtubule nucleation factor. (782 aa) |
| | ENSMLEP00000021044 | WD_REPEATS_REGION domain-containing protein. (259 aa) |
| | DAXX | Death domain associated protein. (752 aa) |
| | ZNF385B | Zinc finger protein 385B. (471 aa) |
| | PRDM1 | PR/SET domain 1. (825 aa) |
| | PPP1R13B | Protein phosphatase 1 regulatory subunit 13B. (1091 aa) |
| | SMYD2 | SET and MYND domain containing 2. (432 aa) |
| | RAD9A | RAD9 checkpoint clamp component A. (355 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | CDK5 | Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (302 aa) |
| | FOXP4 | Forkhead box P4. (678 aa) |
| | TP53INP1 | Tumor protein p53 inducible nuclear protein 1. (241 aa) |
| | TAF10 | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa) |
| | LOC105531555 | Uncharacterized protein. (91 aa) |
| | LOC105545834 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (470 aa) |
| | ENSMLEP00000018319 | WD_REPEATS_REGION domain-containing protein. (418 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (240 aa) |
| | BRD9 | Bromodomain containing 9. (596 aa) |
| | ENSMLEP00000018038 | Uncharacterized protein. (427 aa) |
| | PIP4P2 | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa) |
| | BLM | BLM RecQ like helicase. (1392 aa) |
| | CHD3 | Chromodomain helicase DNA binding protein 3. (2000 aa) |
| | SGK1 | Non-specific serine/threonine protein kinase. (526 aa) |
| | TAF6 | TATA-box binding protein associated factor 6. (738 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (595 aa) |
| | SETD9 | SET domain containing 9. (273 aa) |
| | ING2 | Inhibitor of growth protein. (280 aa) |
| | PIP4K2A | Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (358 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (138 aa) |
| | AURKA | Aurora kinase A; Belongs to the protein kinase superfamily. (384 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | DYRK4 | Dual specificity tyrosine phosphorylation regulated kinase 4. (520 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa) |
| | CDK5R1 | Cyclin-dependent kinase 5 activator. (307 aa) |
| | KAT6A | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2003 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (542 aa) |
| | TBP | TATA-box binding protein. (328 aa) |
| | HIPK4 | Homeodomain interacting protein kinase 4. (616 aa) |
| | LOC105539645 | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (192 aa) |
| | LOC105541098 | Ubiquitin-like domain-containing protein. (156 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (280 aa) |
| | TAF1L | Transcription initiation factor TFIID subunit. (1884 aa) |
| | KMT5A | Lysine methyltransferase 5A. (313 aa) |
| | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (580 aa) |
| | TAF11 | TATA-box binding protein associated factor 11. (211 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa) |
| | PRKAB1 | Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa) |
| | BRPF3 | Bromodomain and PHD finger containing 3. (1205 aa) |
| | EHMT1 | Euchromatic histone lysine methyltransferase 1. (1255 aa) |
| | ING1 | Inhibitor of growth protein. (419 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (690 aa) |
| | ENSMLEP00000006240 | Ubiquitin-like domain-containing protein. (127 aa) |
| | ZNF385A | Zinc finger protein 385A. (414 aa) |
| | AIRE | Autoimmune regulator. (524 aa) |
| | ENSMLEP00000006533 | Uncharacterized protein. (189 aa) |
| | TP73 | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (601 aa) |
| | CSNK2A2 | Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (323 aa) |
| | PML | Promyelocytic leukemia. (858 aa) |
| | LOC105551588 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (455 aa) |
| | ENSMLEP00000006951 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (268 aa) |
| | CHD4 | Uncharacterized protein. (1923 aa) |
| | TXNDC11 | Thioredoxin domain containing 11. (919 aa) |
| | MBD3L1 | Methyl-CpG binding domain protein 3 like 1. (200 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa) |
| | LOC105529834 | Uncharacterized protein. (270 aa) |
| | ENSMLEP00000007973 | TAFII28 domain-containing protein. (205 aa) |
| | LOC105536598 | Ubiquitin-like domain-containing protein. (156 aa) |
| | PRKAG3 | Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa) |
| | NOC2L | NOC2 like nucleolar associated transcriptional repressor. (755 aa) |
| | TAF15 | TATA-box binding protein associated factor 15. (592 aa) |
| | PIP4P1 | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (284 aa) |
| | JMY | Junction mediating and regulatory protein, p53 cofactor. (899 aa) |
| | CHEK2 | Checkpoint kinase 2. (558 aa) |
| | AURKC | Aurora kinase C; Belongs to the protein kinase superfamily. (309 aa) |
| | ENSMLEP00000010500 | WD_REPEATS_REGION domain-containing protein. (410 aa) |
| | TAF5 | TATA-box binding protein associated factor 5. (656 aa) |
| | TAF12 | TATA-box binding protein associated factor 12. (213 aa) |
| | ENSMLEP00000010931 | Uncharacterized protein. (79 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (898 aa) |
| | PPP2R1A | Protein phosphatase 2 scaffold subunit Aalpha. (589 aa) |
| | ENSMLEP00000011388 | Ubiquitin-like domain-containing protein. (120 aa) |
| | PIP4K2B | Phosphatidylinositol-5-phosphate 4-kinase type 2 beta. (399 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (529 aa) |
| | TTC5 | Tetratricopeptide repeat domain 5. (440 aa) |
| | TAF4B | TATA-box binding protein associated factor 4b. (867 aa) |
| | RFC5 | Replication factor C subunit 5. (340 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | ENSMLEP00000013654 | Uncharacterized protein. (83 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (681 aa) |
| | ENSMLEP00000013828 | Uncharacterized protein. (371 aa) |
| | PHF20 | PHD finger protein 20. (1012 aa) |
| | ENSMLEP00000014379 | Uncharacterized protein. (297 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (417 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (335 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (275 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1059 aa) |
| | ENSMLEP00000014695 | TAFII28 domain-containing protein. (195 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (759 aa) |
| | TAF9B | TATA-box binding protein associated factor 9b. (251 aa) |
| | HIPK3 | Homeodomain interacting protein kinase 3. (1215 aa) |
| | MDM4 | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa) |
| | C17orf113 | Chromosome 17 open reading frame 113. (570 aa) |
| | RBBP7 | RB binding protein 7, chromatin remodeling factor. (469 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (886 aa) |
