Your Input: | |
| | H3-4 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | LOC105528801 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | UBXN1 | UBX domain protein 1. (310 aa) |
| | ENSMLEP00000006951 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (268 aa) |
| | LOC105529341 | Histone H4. (103 aa) |
| | LOC105529323 | Histone H4. (103 aa) |
| | LOC105537674 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa) |
| | H2BC5 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (477 aa) |
| | ENSMLEP00000006240 | Ubiquitin-like domain-containing protein. (127 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (690 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (352 aa) |
| | LOC105547581 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105549788 | Histone H4. (103 aa) |
| | ENSMLEP00000005424 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (142 aa) |
| | MDC1 | Mediator of DNA damage checkpoint 1. (1838 aa) |
| | ENSMLEP00000005277 | Small ubiquitin-related modifier. (103 aa) |
| | LOC105534329 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa) |
| | H2BC13 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ABL1 | Tyrosine-protein kinase. (1149 aa) |
| | LOC105529328 | Histone H4. (103 aa) |
| | LOC105529342 | Histone H4. (103 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (280 aa) |
| | LOC105541098 | Ubiquitin-like domain-containing protein. (156 aa) |
| | LOC105529322 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (615 aa) |
| | H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H4C8 | H4 clustered histone 8. (103 aa) |
| | LOC105549789 | Histone H4. (103 aa) |
| | LIG3 | DNA ligase. (1009 aa) |
| | LOC105547557 | Histone H4. (103 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase. (1017 aa) |
| | H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105529329 | Histone H4. (103 aa) |
| | ENSMLEP00000002683 | annotation not available (103 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | LOC105547589 | Histone H4. (103 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (584 aa) |
| | H2BC1 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | H2BC11 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSMLEP00000001761 | annotation not available (103 aa) |
| | LOC105529318 | Histone H4. (103 aa) |
| | UBE2NL | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa) |
| | KDM4A | Uncharacterized protein. (1063 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa) |
| | LOC105529316-2 | Histone H2B type 1. (126 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (138 aa) |
| | ENSMLEP00000000876 | Ubiquitin-like domain-containing protein. (132 aa) |
| | LOC105529316 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC14 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC105529337 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC105547273 | Histone H4. (103 aa) |
| | RNF4 | Ring finger protein 4. (190 aa) |
| | LOC105544083 | MPN domain-containing protein. (285 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (465 aa) |
| | WRN | WRN RecQ like helicase. (1404 aa) |
| | EYA4 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (620 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (595 aa) |
| | UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa) |
| | BAZ1B | Bromodomain adjacent to zinc finger domain 1B. (1611 aa) |
| | KPNA2 | Importin subunit alpha; Functions in nuclear protein import. (529 aa) |
| | ENSMLEP00000029549 | Histone H2B; Belongs to the histone H2B family. (136 aa) |
| | TMEM182 | Transmembrane protein 182. (229 aa) |
| | ENSMLEP00000030622 | Small ubiquitin-related modifier. (81 aa) |
| | ENSMLEP00000030942 | Dpoe2NT domain-containing protein. (96 aa) |
| | TDRD3 | Tudor domain-containing protein. (405 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (307 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (645 aa) |
| | POLD4 | Uncharacterized protein. (107 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (504 aa) |
| | RNF169 | Ring finger protein 169. (564 aa) |
| | PPP4R2 | Uncharacterized protein. (417 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1527 aa) |
| | TIMELESS | Timeless circadian regulator. (1208 aa) |
| | ENSMLEP00000033875 | Histone H2B; Belongs to the histone H2B family. (134 aa) |
| | XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa) |
| | ATRIP | ATR interacting protein. (772 aa) |
| | ENSMLEP00000034242 | Uncharacterized protein. (173 aa) |
| | SUMO3 | Ubiquitin-like domain-containing protein. (189 aa) |
| | DNTT | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (510 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (409 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (268 aa) |
| | BAP1 | Ubiquitin carboxyl-terminal hydrolase. (736 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2288 aa) |
| | EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (538 aa) |
| | PAXIP1 | PAX interacting protein 1. (1063 aa) |
| | SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (719 aa) |
| | LOC105541671 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (252 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (402 aa) |
| | EYA3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (563 aa) |
| | ENSMLEP00000037154 | Uncharacterized protein. (223 aa) |
| | ENSMLEP00000037330 | Small ubiquitin-related modifier. (103 aa) |
| | RAD51B | RAD51 paralog B. (426 aa) |
| | POLK | DNA polymerase kappa. (870 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2466 aa) |
| | PWWP2A | PWWP domain containing 2A. (755 aa) |
| | SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (1070 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (346 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (449 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1312 aa) |
| | PPP5C | Serine/threonine-protein phosphatase. (510 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (254 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1977 aa) |
| | H2BC15 | Histone H2B; Belongs to the histone H2B family. (158 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (620 aa) |
| | RAD51C | RAD51 paralog C. (377 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (379 aa) |
| | RFC1 | Replication factor C subunit 1. (1148 aa) |
| | DCLRE1C | DNA cross-link repair 1C. (627 aa) |
| | POLM | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (494 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (886 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa) |
| | POLD1 | DNA polymerase. (1134 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1247 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1365 aa) |
| | CNPPD1 | Cyclin Pas1/PHO80 domain containing 1. (417 aa) |
| | UBE2I | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (194 aa) |
| | LOC105537651 | DUF4502 domain-containing protein. (192 aa) |
| | EXO1 | Exonuclease 1. (752 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1736 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (908 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (336 aa) |
| | ENSMLEP00000025584 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (284 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (415 aa) |
| | APBB2 | Amyloid beta precursor protein binding family B member 2. (760 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3675 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (510 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | ENSMLEP00000024034 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (142 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1351 aa) |
| | POLD3 | Uncharacterized protein. (454 aa) |
| | ENSMLEP00000023788 | RMI1_N domain-containing protein. (122 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (2965 aa) |
| | RECQL4 | RecQ like helicase 4. (1144 aa) |
| | ENSMLEP00000023688 | Uncharacterized protein. (250 aa) |
| | MEIOB | Meiosis specific with OB-fold. (407 aa) |
| | SLC23A3 | Solute carrier family 23 member 3. (618 aa) |
| | POLH | DNA polymerase eta. (712 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (531 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | SUMO1 | Ubiquitin-like domain-containing protein. (62 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (556 aa) |
| | KDM4B | Lysine demethylase 4B. (1130 aa) |
| | RAD9A | RAD9 checkpoint clamp component A. (355 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit. (3556 aa) |
| | H2BW1 | H2B histone family member W, testis specific; Belongs to the histone H2B family. (175 aa) |
| | SIRT7 | Sirtuin 7. (323 aa) |
| | UBE2V2 | Ubiquitin conjugating enzyme E2 V2. (155 aa) |
| | ENSMLEP00000018394 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (129 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (240 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (147 aa) |
| | PARP2 | Poly [ADP-ribose] polymerase. (583 aa) |
| | BLM | BLM RecQ like helicase. (1392 aa) |
| | CHEK1 | Checkpoint kinase 1. (480 aa) |
| | POLQ | DNA polymerase theta. (2468 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (551 aa) |
| | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4772 aa) |
| | ENSMLEP00000015948 | Uncharacterized protein. (90 aa) |
| | RTEL1-2 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1116 aa) |
| | ENSMLEP00000015845 | Rad60-SLD domain-containing protein. (78 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | TDP1 | Tyrosyl-DNA phosphodiesterase 1. (603 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (759 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (400 aa) |
| | ENSMLEP00000014682 | IBB domain-containing protein. (407 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1059 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (417 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (299 aa) |
| | SIRT6 | Sirtuin 6. (355 aa) |
| | ENSMLEP00000014080 | Uncharacterized protein. (103 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (681 aa) |
| | ENSMLEP00000013654 | Uncharacterized protein. (83 aa) |
| | ENSMLEP00000013375 | Small ubiquitin-related modifier. (100 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | RFC5 | Replication factor C subunit 5. (340 aa) |
| | SPIDR | Scaffold protein involved in DNA repair. (761 aa) |
| | ENSMLEP00000012088 | Histone H2B; Belongs to the histone H2B family. (129 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (274 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (119 aa) |
| | ENSMLEP00000011388 | Ubiquitin-like domain-containing protein. (120 aa) |
| | APBB1 | Amyloid beta precursor protein binding family B member 1. (738 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (898 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (323 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa) |
| | ENSMLEP00000010931 | Uncharacterized protein. (79 aa) |
| | LOC105532537 | Importin subunit alpha; Functions in nuclear protein import. (510 aa) |
| | LOC105554521 | DNA_pol_E_B domain-containing protein. (252 aa) |
| | RAD51D | RAD51 paralog D. (347 aa) |
| | CHEK2 | Checkpoint kinase 2. (558 aa) |
| | ENSMLEP00000009932 | Histone H2B; Belongs to the histone H2B family. (133 aa) |
| | NHEJ1 | Non-homologous end joining factor 1. (299 aa) |
| | ENSMLEP00000009721 | Uncharacterized protein. (232 aa) |
| | TDP2 | Tyrosyl-DNA phosphodiesterase 2. (358 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (565 aa) |
| | BRCC3 | MPN domain-containing protein. (297 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa) |
| | LOC105536598 | Ubiquitin-like domain-containing protein. (156 aa) |
| | LOC105534783 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | CLSPN | Claspin. (1072 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1192 aa) |
