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CDK3 CDK3 POLE4 POLE4 MCM9 MCM9 MCM4 MCM4 ORC3 ORC3 RPA2 RPA2 TM4SF19 TM4SF19 LOC105555268 LOC105555268 POLE3 POLE3 ORC5 ORC5 ORC6 ORC6 MEIOB MEIOB CDC7 CDC7 RPA3 RPA3 LOC105541595 LOC105541595 MCM10 MCM10 POLA1 POLA1 MCM2 MCM2 MCM6 MCM6 MCM5 MCM5 POLE POLE MCM3 MCM3 CDT1 CDT1 ORC4 ORC4 GMNN GMNN CDC45 CDC45 ORC2 ORC2 ENSMLEP00000031844 ENSMLEP00000031844 PRIM2 PRIM2 ENSMLEP00000030942 ENSMLEP00000030942 ORC1 ORC1 POLA2 POLA2 RPA1 RPA1 PRIM1 PRIM1 CDC6 CDC6 DBF4 DBF4 ENSMLEP00000006951 ENSMLEP00000006951 LOC105554521 LOC105554521 ENSMLEP00000010931 ENSMLEP00000010931 MCM7 MCM7 MCM8 MCM8 CDK2 CDK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (119 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1141 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
ORC3Origin recognition complex subunit 3. (646 aa)
RPA2Replication protein A2. (356 aa)
TM4SF19Uncharacterized protein. (209 aa)
LOC105555268Protein kinase domain-containing protein. (542 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
ORC5Origin recognition complex subunit 5. (421 aa)
ORC6Origin recognition complex subunit 6. (203 aa)
MEIOBMeiosis specific with OB-fold. (407 aa)
CDC7Protein kinase domain-containing protein. (574 aa)
RPA3Replication protein A3. (121 aa)
LOC105541595RPA_C domain-containing protein. (250 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (822 aa)
POLA1DNA polymerase. (1420 aa)
MCM2DNA helicase; Belongs to the MCM family. (757 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2288 aa)
MCM3DNA helicase; Belongs to the MCM family. (853 aa)
CDT1Chromatin licensing and DNA replication factor 1. (470 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
GMNNGeminin DNA replication inhibitor. (209 aa)
CDC45Cell division cycle 45. (598 aa)
ORC2Origin recognition complex subunit 2. (577 aa)
ENSMLEP00000031844Uncharacterized protein. (347 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (509 aa)
ENSMLEP00000030942Dpoe2NT domain-containing protein. (96 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (861 aa)
POLA2Uncharacterized protein. (548 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (595 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa)
DBF4DBF4 zinc finger. (674 aa)
ENSMLEP00000006951Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (268 aa)
LOC105554521DNA_pol_E_B domain-containing protein. (252 aa)
ENSMLEP00000010931Uncharacterized protein. (79 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
MCM8MCM domain-containing protein; Belongs to the MCM family. (880 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
Your Current Organism:
Mandrillus leucophaeus
NCBI taxonomy Id: 9568
Other names: M. leucophaeus, Papio leucophaeus, drill
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